UTI & STIs Flashcards

1
Q

Most common cause of uncomplicated UTI?

A

E. Coli

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2
Q

Urease producer of uncomplicated UTI?

A

P. mirabilis

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3
Q

Who is an uncomplicated UTI patient?

A

Healthy, non-pregnant adult female

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4
Q

Gram (-) cause of complicated UTI

A

P. aeruginosa

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5
Q

G (+) urease producer that can cause complicated UTI

A

S. Saprophyticus

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6
Q

Pathology of UTI

A

Ascending - usu. E. Coli from GI or iratrogenesis

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7
Q

Complicated UTI patient?

A

DM, pregnant, Hx pyelo, Sx > 7days before Tx, MDR, HAP, renal failure, HX UTI as a child

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8
Q

STI cause of a UTI

A

C. trachomatis/ N. gonorrhea

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9
Q

Tx UTI

A

Bactrim…then Cipro

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10
Q

Tx pyelonphritis

A

Cipro/Levo

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11
Q

Spirochete with slow rotational motility; produces AB’s to somatic proteins and cardiolipin of host mitochondrial membranes

A

T. pallidum

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12
Q

What org causes syphilis

A

T. pallidum

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13
Q

VF of T. pallidum

A

membrane protein = adhesion, fibronectin, hyaluronidase

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14
Q

Chancre with smooth base, raised border that is firm and indurated; painless

A

syphilis chancre

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15
Q

Which stage is the chancre in syphilis

A

primary (entry stage)

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16
Q

The stage of syphilis that is the highly infectious stage; Latent stage; maculopapular rash (can spread to palms)

A

secondary stage

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17
Q

Stage of syphilis where there are neuro sx, cardio sx, granuomata systemic

A

tertiary stage: usu 5-20 years later

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18
Q

Dx Syphilis

A

Chancre; Dark field micro for treponemes; Nontreponemal: cardiolipin flocculation test; Treponemal: specific AB tests

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19
Q

Hutchinson’s Triad

A

notched incisors, keratitis, 8th nerve deafness (congenital syphilis)

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20
Q

Syphilis lesions primarily due to

A

cytokines = inflammation

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21
Q

G(-) kidney-beaned shaped cells; fastidious growth

A

N. gonorrhoeae

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22
Q

VFs of N. gonorrhoeae

A

Pili, porin protein, IgA protease, & plasmid chromosome mediated drug resistance

23
Q

PH: N. gonorrhoeae

A

entry & attachment to epithelia via pili & surface proteins. Injury to host cell via LPS, which allows for spread to other tissues

24
Q

Clinical presentation of gonorrhea

A

Males: mucopurulent discharge in anterior urethra

Females: presence in endocervix with urethral colonization

25
Q

Gold Standard for Gonorrhea Dx

A

Nucleic Acid Amp.

26
Q

Migratory polyarthralgia; Arthritis-dermatitis syndrome is indicative of…

A

Disseminated gonoccoal infection (DGI)

27
Q

Gonorrhea is most common in:

A

adolescents; rates are increasing in the US due to change in sex habits, detection, & beta-lacatamse resistance

28
Q

Can gonorrhea be transmitted to neonates during birth?

A

Yes

29
Q

Obligate intra-cellular, G (-) without peptidoglycan. Requires host ATP

A

Chlamydia

C. trachomatis

30
Q

Inflammation in Chlamydia is due to

A

toxin-producing strains (Toxin B)

Toxins break down proteins in host cells allowing mucosal cells to separate

31
Q

Clinical spectrum of Chlamydia

A

similar to gonorrhea: urethritis (thin-watery discharge), cervicitis (yellow-green discharge), salpingitis, epididymitis, PID

32
Q

Causes post-partum fever and chorioamnionitis in pregnant women

A

Nongonoccal urethritis

33
Q

Organism that causes NGU

A

Ureaplasma urealyticum

34
Q

Main réservoir of ureaplasma urealyticum in NGU

A

GU tract of sexually active persons

35
Q

Causes ~50% of nongonococcal, nonchlamydial urethritis in men

A

Ureaplasma urealyticum: NGU

36
Q

Flagellated protozoan; exists as a trophozoite ONLY; extracellular anaerobe

A

T. vaginosis

37
Q

How is T. vaginosis transmitted?

A

STD only

38
Q

Frothy malodorus vagina a/w cellular atypism

A

T. vaginosis

39
Q

Is Bacterial vaginosis an STD?

A

No

40
Q

Opportunistic pathogen due to the overgrowth of T. vaginosis

A

Bacterial vaginosis

41
Q

Criteria for Bacterial Vaginosis (any 3)

A
Clue cells
Fishy amine odor
Vaginal pH > 4.5
Curved (-) rods
Homogenous secretion
42
Q

Underlying causes of candida

A

absence of normal flora, intro to abnormal site, change in micoenviornment, immune defect, broad spectrum abx

43
Q

Form pseudohyphae, germ tubes, hyphae

A

C. albicans: vulvovaginal candidiasis

44
Q

Clinically presents as vulvar edema, erythema, cottage cheese appearance

A

Vulvovaginal candidiasis

45
Q

Dx vulvovaginal candidiasis

A

vaginal swab: stain & culture

46
Q

Germ tube test is strongly presumptive of

A

Vulvovaginal candidiasis

47
Q

Predisposing factors of vulvovaginal candidiasis

A

Local- tight clothing, warm macerate skin, incorrect toilet habits, sensitization, physical damage, IUD, trauma w/ intercourse

48
Q

What org causes chancroid?

A

H. ducreyi; Tropical countires

49
Q

This chancre is a soft, tender ulcer with sharp margins. It is painful and bleeds. No induration

A

Chancroid ulcer

50
Q

Dx of chancroid

A

History is critical.

Media needs growth supplements for growth.
PCR-based method

51
Q

Which organisms cause PID

A

N. gonorrhoeae or C. trachomaits

52
Q

PH of PID

A

Gonorrhea moves via retrograde menses to uterus/fallopian tubes & colonize during menses sloughing.

Spreading causes scars and inflammation

53
Q

Dx of PID

A

inflammation = fever
leukocytosis
elevated ESR

54
Q

Lower abdominal pain, abnormal vaginal discharge, painful intercourse, increased pain during menstruation, irregular menses, fever, chills, scarring.

What is this condition?

A

PID