Uterotonic Drugs Flashcards
Oxytocin mode of admin?
IV but no bolus
Oxytocin mechanism?
Increase intracellular Ca
Oxytocin side effects (4)?
- Nausea
- Flushing
- Tachycardia
- Hypotension
Oxytocin contraindications?
- Vasa previa
2. Cord prolapse
What is the trade name of Carboprost?
Hemabate
What is the mechanism of carboprost?
PG analog
What is the mode of admin for carboprost?
Injection
What are 2 side effects of carboprost?
- Nausea
2. Diarrhea
What are contraindications for carboprost?
Cardiac, pulmonary, renal, hepatic dz; acute PID
What is the trade name of methylergonovine?
Methergine
What is the mode of admin for methylergonovine?
IM, IV, or PO
What’s the mechanism of methylergonovine?
Binds 5-HT2A serotonin receptos leading to uterine SM contraction?
What are the negative side effects of methylergonovine (4)?
- HTN
- Headache
- MI
- Seizure
What’s are the 2 contraindications for methylergonovine?
- Pre-existing HTN
2. Pre-eclampsia
What’s the trade name for misoprostol?
Cytotec
What’s the mechanism of misoprostol?
PGE1 analog
What are the side effects of misoprostol?
Diarrhea, abdominal pain
What are the contraindications for misoprostol?
None really, but careful in asthmatic patients
What is the trade name of dinoprostone?
Cervidil
What’s the mechanism of dinoprostone?
PG
What are the side effects of dinoprostone?
Nausea, vomiting, diarrhea, fever, back pain, flushing, tingly feeling, warmth in vagina, dizziness
What are the contraindications for dinoprostone?
Cardiac, pulmonary, renal, hepatic dz; acute PID, concomitant IV oxytocin, h/o C-section, h/o major uterine surgery or difficult labor
