Uterine Cancer Flashcards
Stage I uterine cancer
Confined to uterine corpus
Stage II uterine cancer
INvades cervix
Stage III uterine cancer
Local/regional spread to adnexa, vagina, levic nodes, para-aoritc nodes
Stage IVA uterine cancer
Bowel or bladder mets
Biggest risk factor for endometrial cancer
Elevated estrogen
Which mutation within the Lynch syndrome genes is a higher risk of endometrial cancer?
MSH6
Endometrial cancer screening for patients with HNPCC
Yearly TVUS every eyar at 30-35
What can you do to reduce risk for endometrial cancer for a patient with HNPCC? When?
Prophylactic BSO at 35
Treatment for early stage Endometrioid well differentiated tumor who want to preserve fertility?
High dose progestins
Which Stage I patients should get adjuvant radiation?
Grade 3 regardless of invasion depth
Grade 2 or 3 with <50% invasion
Any grade with >50% invasion
What happens when adding chemotherapy to adjuvant radiation in stage I endometrial cancer?
not superior to radiation alone
Treatment for Stage III endometrial cancer?
Chemotherapy +/- RT
Teratment for isolated vaginal recurrence
No prior pelvic RT: give pelvic RT
Prior pelvic RT: then surgery or systemic therapy
What is the chemotherapy backbone for standard advanced endometrial cancer?
Carbo + Taxol
2nd line SOC for metastatic/recurrent endometrial cancer after chemo?
Pembro + Len
