Small Cell Lung Cancer

Question 1

IHC findings of small cell?

Answer 1

Chromogranin+
Synaptophysin+

Question 2

What is limited stage SCLC?

Answer 2

Confined to one hemithorax and regional LNs
Excludes pleural/pericardial effusion

Question 3

Preferred treatment for limited stage SCLC with N0 dusease?

Answer 3

Up front surgery and adjuvant Cis+Etop x4C

Question 4

Preferred treatment for limited stage SCLC with N+?

Answer 4

Chemoradiation with Cisplatin + Etoposide

Question 5

What is the benefit of PCI?

Answer 5

Reduced risk of brain mets in LS-SCLC, but no effect on survival

Question 6

Who qualifies to get prophylactic cranial irradiation?

Answer 6

LS-SCLC with a good response to definitive therapy and adjuvant chemotherapy

Question 7

Preferred treatment for ES-SCLC? (2)

Answer 7

Carboplatin + Etoposide + Atezolizumab
Carboplatin + Etoposide + Durvalumab

Question 8

What is the difference in chemotherapy you can use in the ES vs LS-SCLC?

Answer 8

In ES, carboplatin can be substituted for cisplatin

Question 9

What supportive care treatment can be used for myeloprotection for patients with SCLC being treated?

Answer 9

Trilaciclib

Question 10

Second line therapy for ES-SCLC (2)

Answer 10

Lurbinectidin
Topotecan

Question 11

When can you re-treat patients with ES-SCLC with carboplatin+etoposide?

Answer 11

Platinum-free interval of at least 90 days

Question 12

Treatment paradigm for early stage large cell neuroendocrine tumors of the lung

Answer 12

Surgery with adjuvant cisplatin + etoposide x4

Question 13

Treatment for unresectable large cell neuroendocrine tumors of the lung

Answer 13

ChemoRT with Cis/Etop followed by additional chemotherapy for 4 cycles

Question 14

Treatment for metastatic large cell neuroendocrine tumor of lung

Answer 14

PLatinum + Etoposide+ IO

Question 15

Preferred teratment regimens for eadnaced epithelioid mesothelioma?

Answer 15

Cis + pemetrexed
Cis + Pem + bev
Ipi/Nivo

Question 16

Treatment paradigm for early stage epithelial mesothelioma

Answer 16

Induction chemo with Cis + Pemetrexed
Surgery
Consider hemithoracic RT after

Question 17

Patient with resectable LS-SCLC, found to have T2N0 disease during surgery. Adjuvant therapy?

Answer 17

Cis + Etop x4C

Question 18

Patient with resectable LS-SCLC, found to have T2N1 disease during surgery. Adjuvant therapy?

Answer 18

Cis + Etop +/- mediastinal RT

Question 19

Patient with resectable LS-SCLC found to have N2 disease during surgery. Adjuvant therapy?

Answer 19

Sequential or concurrent chemoRT with Cis + Etop

Question 20

Preferred systemic therapy for biphasic mesothelioma?

Answer 20

Ipi/Nivo

Question 21

Preferred systemic therapy for sarcomatoid mesothelioma?

Answer 21

Ipi/Nivo