Uronic Acid Pathway

Question 1

5 major bio synthetic functions of Uronic Acid Pathway?

Answer 1

Synthesis or sugar moieties for glycoproteins, heparin/heparin sulfate formation, production of UDP-glucoronate for various conj. rxns, L-ascorbate( vitamin c) formation, minor route for formation of pentodes that can enter HMS

Question 2

L-Gulonolactone oxidase is an enzyme that is absent in primates, fish, flying mammals, and songbirds (True or False)

Answer 2

True. They need it to produce vitamin C.

Question 3

Wastes of Uridine Diphosphate (UDP)- Glucose

Answer 3

Glycoproteins, Heparin, Vitamin C, Pentoses, Drug detox, Steroid hormone conjugation, Bilirubin conjugation

Question 4

Glucokinase (inducible) Pathway in liver and muscle

Answer 4

Not inducible in ruminant liver due to low glucose absorption from GI, Liver and pancreatic beta cell specific

Question 5

Hexokinase (non-inducible) Pathway- in Liver and Muscle

Answer 5

Present in all mammalian cells, strongly inhibited by Glc-6-P, activity in RBCs declines with age, responsible for erythrocyte turnover