Urology/Renal (Alice) Flashcards
2 mcc of edema
chronic venous insufficiency
DVT
swelling of limbs w. thickening of skin post op on the side of the surgery
lymphedema
surgery mc associated w. lymphedema
breast ca
rxn to some meds vs inherited d.o that causes fluid to leak out of bv’s into tissues
angioedema
4 meds commonly associated w. edema
oral dm
htn meds
nsaids
estrogens
edema around the eyes and lower legs
renal dz
edema in the legs/abdomen/lungs
chf
3 sx of edema
heavy legs
hyperpigmentation
sob
work up for edema
low suspicion for dvt: d-dimer
US
ABI
UA
tx for edema
compression stockings
leg elevation 30 mins, 4x daily
Na restriction
diuretics
contraindication for diuretics w. edema
chronic venous insufficiency
mc type of bladder ca
transitional cell carcinoma
painless hematuria in a smoker is _ until proven otherwise
bladder ca
gs dx for bladder ca
cystoscopy w. bx
tx for bladder ca
-endoscopic resection w. cystoscopy q 3 mos
-recurrent or multiple lesions: chemo
6 rf for bladder ca
smoking
aromatic amines
schistosomiasis
truck drivers
petroleum workers
cyclophosphamide
tx for bladder ca
stage 0: TURB + chemo
stages II/III: radical cystectomy, lymph node dissection
stage IV: cystectomy + chemo
indications for partial cystectomy w. bladder ca
suprficial, isolated tumor
apical w. 3 cm margin from any orifices
how does bacillus calmette guerin work for bladder ca tx
attenuated tb vaccine -> initiates immune response
classic sign of urinary retention in elderly pt’s
ams
what is POUR
post op urinary retention
rf for POUR
spinal anesthesia
epidural anesthesia
5 causes of urinary retention
obstructive
neurogenic
traumatic
extraurinary
infectious
4 obstructive causes of urinary retention
stricture
calculi
neoplasm
foreign body
4 causes of neurogenic urinary retention
MS
parkinsons
CVA
post op
3 traumatic causes of urinary retention
injury to: urethra, bladder, spinal cord
3 causes of extraurinary urinary retention
fecal impaction
AAA
rectal/retropeitoneal mass
4 causes of infectious urinary retention
abscess
cystitis
genital herpes
zoster
7 rf for urinary retention
male
bph
epidural
spinal/prolonged anesthesia
antihistamines
narcotics
pelvic/perineal procedures
POUR dx
inability to void w.in 8 h after surgery or 8 h after catheter removal
3 complications of urinary retention
infxn
ischemia
long term dysfxn
acute urinary retention is (painless vs painful):
chronic urinary retention is:
acute: painful
chronic: painless
4 sx of chronic urinary retention
frequent urination of small amt
sensation of fullness
suprapubic dullness
rounded midline mass
chronic urinary retention is caused by _ dyssynergia
detrusor muscle
5 causes of chronic urinary retention
SCI
MS
obstructive
recurrent UTI/bladder infxns
constipation/encopresis
dx of urinary retention is made by _ mL of urine on a PVR
> /= 500 mL
tx for urinary retention
catheterization x 24 hr followed by voiding trial
tx for detrusor sphincter dyssenergia
botox
surgical incision of bladder neck
w. massive bladder distension, how much urine can be drained immediately
1 L
slow drainage of remaining to avoid vasovagal
cystitis is characterized by
dysuria w.o urethral discharge
6 sx of cystitis
dysuria
urgency
frequency
hematuria
new onset incontinence
malodorous urine
gs dx for cystitis
urine culture:
women: > 100 k CFU/mL
men or cath pt: > 1,000 CFU/mL
tx for cystitis
</= 65 yo: nitro vs bactrim vs fosfomycin
complicated: cipro
postcoital: single dose bactrim vs cephalexin
pregnant: nitro vs cephalexin
sx of cystitis that are relieved w. voiding
hunner’s ulcer on cystoscopy
interstitial cystitis
sx of pyelonephritis
dysuria
fever
flank pain
n/v
CVA tenderness
tx for pyelonephritis
cipro
levo
cephalexin
toxic/unable to tolerate PO abx/pregnant: ceftriaxone
5 indications for hospitalization w. pyelo
persistent fever > 101
persistent pain
inability to take fluids or PO meds
suspected urinary obstruction
unable to adhere to tx
definition of recurrent UTI
2 uncomplicated UTI x 6 mos
OR
3 uncomplicated UTIs in the previous year
definition of UTI relapse (2)
recurrence of UTI w.in 2 weeks of tx
caused by the same organism
refinition of UTI reinfection
recurrent UTI caused by different bacteria
which is mc: UTI relapse or reinfection
reinfection
UTI prophylaxis
once daily low dose:
nitro vs bactrim vs cephalexin vs cipro
2 causes of urethritis
infectious
noninfectious (trauma/foreign body)
2 mc pathogens associated w. urethritis
c. trachomatis
n. gonorrhea
3 sx of urethritis
discharge
dysuria
pruritis
dx for urethritis (4)
NAAT of first voided urine
gram stain
UA w.culture
prostate exam
tx for urethritis
(-) gonococci: azithro vs doxy
(+) gonococci: azithro PLUS ceftriaxone (tx for gonorrhea and chlamydia)
recurrent: metro vs tinidazole PLUS azithro
dysuria
unilateral scrotal pain/swelling
epididymitis
mcc of epididymitis: <35 yo vs >35 yo
< 35 yo: chlamydia, gonorrhea
> 35 yo: e.coli
what PE sign is associated w. epididymitis
prehn sign: relief w. elevation of scrotum
tx for epididymitis
> 35 yo: levofloxacin vs ofloxacin
< 35 yo: doxy PLUS ceftriaxone
indicaton to tx sexual partner w. epididymitis
contact w.in 60 days of sx onset
sudden onset: f/c, lbp, frequency, urgency, dysuria
prostatitis
mcc of prostatitis
< 35 yo: chlamydia, gonorrhea
> 35 yo: e.coli
tx for prostatitis
< 35 yo: azithro vs doxy PLUS ceftriaxone
> 35 yo: fluoroquinolones vs bactrim x 1 month
what tx is contraindicated for prostatitis
prostate exam/massage -> can lead to sepsis
3 indications for increased maintenance fluid needs
fever
hyperventilation
increased catabolic rate
body fluids are _molar
isomolar
when fluid losses from any site amount >/= _ mL, electrolytes should be measured periodically and fluids should be adjusted
1500 mL
when should IVF orders be reevaluated
q 24 hr
q 4-6 hr POD 1
general maintenance IVF guidelines according to Smarty PANCE
2,000-2,500 mL 5% dex in NS OR in LR daily
_ should not be added to IVF in the first 24 post op bc it naturally enters circulation as a result of operative trauma and increased aldosterone
K+
fluid loss thru a NGT < _ can be replaced by incvreased maintenance IVF by a similar amt
500 mL/d
protocol for IVF potassium replacement
20 mEq K+ added to every L of fluid
3 indications for potassium replacement
good urine flow
demonstrated deficiency AFTER pathologic losses
not anticipated to start enteral feeding soon
mc type of kidney stone
calcium oxylate
urea splitting organism that is the mcc of infected kidney stones
struvite
mc location for kidney stone obstruction
UVJ
mc tx for kidney stones
lithotripsy
gs test for kidney stones
CT abd/pelvis
UA finding of kidney stones
RBC
pain management for kidney stones
- toradol
- morphine
- opiates - demerol vs dilaudid
4.
2 indications for lithotripsy
stones > 6 cm
intractable pain
stones < _ mm are likely to pass w. hydration and tamsulosin
5
4 types of kidney stone
calcium oxalate
struvite
uric acid
cystine
common cause of calcium oxalate stones
hyperparathyroidism
pt’s w. calcium oxalate stones should avoid _ juice
grapefruit
struvite stones are associated w. (3)
chronic UTI
klebsiella
proteus
rf for uric acid stones
persistently acidic urine:
excess meat/etoh
gout
young boy w. kidney stones probs has what type
cystine
gs dx for kidney stones
CT w.o contrast
tx for kidney stones
pain management
hydration
abx if UTI
tamsulosin
+/- lithotripsy
3 indications for hospitalization w. kidney stones
intractable pain despite oral meds
anuria
renal colic PLUS UTI and/or fever
management of renal stones based on size
< 5 mm: usuall spontaneously pass
5-10 mm: probs need elective lithotripsy
> 10 mm: stent vs nephrostomy vs lithotripsy
gs management of stones > 10 mm
nephrostomy
indication for KUB/IVP w. kidney stones
severe pain
helps find site of obstruction
pt’s w. recurrent kidney stones should maintain a diet restricted in (2)
sodium
protein
primary surgical intervention of choice for struvite stones
percutaneous nephrolithotomy
UA showing crystals that resemble coffin lids
struvite kidney stones
definition of orthostatic hypotn
after a change from supine to standing, drop of:
> 20 mmHg SBP
> 10 mmHg DBP
OR both
6 causes of orthostatic hypotn
autonomic dysfxn: DM, age
meds
postprandial
vagal/carotid sinus hypersensitivity
hypovolemia
adrenal insufficiency
drugs that can cause orthostatic hypotn (lots!)
etoh
alpha blockers (-zosins)
antidepressants
antihypertensives
antiparkinsonism
antipsychotics
bb
diuretics
muscle relaxants
narcotics
PDE5 inhibitors
sedatives
vasodilators
dx for orthostatic hypotn
BP and HR measured after 5 min supine and at 1 and 3 min after standing
what may help dx autonomic dysfxn hypotn
tilt table test
tx for orthostatic hypotn (3)
increased Na
fludrocortisone
midodrine
renal cell carcinoma triad
flank pain
hematuria
palpable abdominal/renal mass
most significant rf for renal cell carcinoma
smoking
transitional cell carcinoma (mc type of bladder cancer) is aka
urothelial carcinoma
what bacteria is associated w. transitional cell carcinoma
schistosoma haematobium
mc non cutaneous ca among males
prostate
screening guidelines for prostate ca
PSA at 50 yo
40 if AA
mc type of prostate ca
adenocarcinoma
mc site of metastasis for prostate ca
bone
dietary rf vs protective factor for prostate ca
rf: high fat
protective: soy
tissue of origin for renal cell carcinoma
renal tubular epithelium
pt pop at greatest risk for renal cell carcinoma
AA
anemia associated w. renal cell carcinoma
normochromic/normocytic
lab finding of renal cell carcinoma
hypercalcemia
dx for renal cell carcinoma
CT
bx
tx for renal cell carcinoma
radical nephrectomy
sites of metastasis for renal cell carcinoma
lung
liver
brain
tumor thrombus to renal vein or IVC
syndrome associated w. renal cell carcinoma and liver dz
stauffer’s syndrome
concern w. adult w. new onset left varicocele
left renal cell carcinoma
left gonadal vein drains into left renal vein
antihypertensive med contraindicated in pt’s w. renal a stenosis
ACEI
what is renal a stenosis
narrowing of renal a -> impedes bloodflow to kidney -> causes renovascular htn (secondary htn)
PE finding of renal a stenosis
renal a bruit
3 sx of renal a stenosis
HTN prior to 30 yo
HTN plus CAD or PVD
htn resistant to 3 or more drugs
pt is place on ACEI and all of a sudden develops acute renal failure or sharp rise in BUN/Cr
renal a stenosis
dx for renal a stenosis: initial vs gs
initial: US
gs: renal arteriography
tx for renal a stenosis
-percutaneous transluminal angioplasty (PTA) PLUS stent
-bypass
nephrectomy
mcc of renal a stenosis
atherosclerosis
other: fibromuscular dysplasia
young woman w. htn makes you think
renal a stenosis due to fibromuscular dysplasia
2 meds to avoid in pt’s w. renal a stenosis
ACEI
K+ sparing diuretics
2 tumor markers for testicular ca
bHCG
alpha fetoprotein
mc presentation of testicular ca
firm, painless, nontender testicular mass
mc solid tumor in men 15-40 yo
testicular ca
mc type of testicular ca
seminoma
rf for testicular ca
hx of cryptochordism
dx for testicular ca
- bHCG and alpha fetoprotein
- scrotal US
- look for mets
3 mc sites of metastasis for testicular ca
abdomen
brain
lung
definitive tx for testicular ca
orchiectomy
+/- chemo
what type of testicular ca is radiosensitive and can be treated w. xrt
seminomatous
_ can be used to identify early relapse in testicular ca
alpha fetoprotein
what is cryptochordism
failure of testicle to descend into the scrotum
t/f: orciopexy as an adult removes the risk of testicular ca
f!
tumor marker for testicular ca based on type
nonseminomatous: (+) AFP and/or bHCG
seminomatous: +/- AFP positive
what 2 types of testicular ca almost never have an elevated AFP
choriocarcinoma
seminoma
what type of testicular ca almost always has elevated bHCG
choriocarcinoma
major s.e of retroperitoneal lymph node dissection
ED
stages of ckd
1: GFR >/= 90
2. GFR 60-89
3. GFR 30-59
4. GFR 15-29
5. GFR < 15
2 major rf for ckd
dm
htn
t/f: ckd is an independent rf for cvd
t!
7 lab findings of ckd
elevated SCr x 3+ mos
GFR < 60 x 3 + mos
persistent proteinuria
anemia
hyperK
hyperphos
hypoCa
UA finding of CKD
broad waxy casts
acid/base effect of ckd
metabolic acidosis
high anion gap
US findings of ckd
symmetrically small echogenic kidneys
target bp for ckd pt’s
< 130/80
indication for ckd referral to nephrology
stage 3+
dietary management of ckd (4)
protein restriction 0.6-0.8 g/day
sodium 2 g/day
K+ restriction
phos restriction
indication for kidney transplant w. ckd
dialysis
ckd 5
t/f: most pt’s w. ckd will die from cvd before receiving transplant
t!
hemodialysis requires a vein > _ mm
the _ vein is ideal for this
5 mm
cephalic
classic hemodialysis access fistula
radial a to cephalic vein (cimino fistula)
2 problems with prosthetic dialysis grafts (used when autogenous fistulas are difficult)
poor patency
high risk for infxn
common second line autogenous fistula formation (preferred over prosthetic graft)
transposing basilic vein to the subcutaneous tissue
all veins used for dialysis require _ (2) prior to cannulization
dilation
arterialization of the wall
flow rates of at least _ are required for dialysis
300 cc/min
2 complications of newly created dialysis AV access
arterial steal
distal extremity ischemia
gs imaging for peripheral AVM
MRI
imaging used to help w. AV fistulas for dialysis
angiography
4 indications for dialysis
uremic sx
GFR < 10
fluid overload unresponsive to diuretics
refractory hyperkalemia
4 uremic sx
pericarditis
encephalopathy
GI
azotemia
2 types of dialysis
hemodialysis
peritoneal
acquired thru an AV fistula or prosthetic graft
hemodialysis
dialysis instilled into peritoneal cavity thru an indwelling catheter
peritoneal dialysis
peritoneal membrane is the dialyzer
3 complications of hemodialysis
infxn
thrombosis
aneurysm
how often is hemodialysis performed
3-5 x/week
3-5 hr/session
complications of peritoneal dialysis
peritonitis: n/v, abd pain, diarrhea, constipation, fever
mc renal tumor in kids
wilms
mc presentation of wilms tumor
palpable abdominal mass that does not cross the midline
4 sx of wilms tumor
elevated renin -> htn
fever
hematuria
anemia
imaging to r.o mets w. wilms tumor
CXR
wilms tumor is same same
nephroblastoma
pt pop mc affected by wilms tumor
otherwise healthy kids < 4 yo
:(
2 rf for wilms tumor
fam hx
horseshoe kidney
4 conditions associated w. wilms tumor (nephroblastoma)
wagr:
wilms tumor
aniridia
GU anomalies (horseshoe kidney)
retardation
dx for wilms tumor/nephroblastoma (4)
US
CT
bx
CXR
never do _ when you suspect wilms tumor
palpate the abdomen
increases risk of rupturing encapsulated tumor
tx for wilms tumor
surgical resection
chemo
classic hpi for wilms tumor
parents found when dressing or bathing kid
umbilical defect
macroglossia
gigantism
visceromegaly
beckwith wiedemann syndrome