Urology, C76 P743-766 Flashcards
Define the following terms:
Cystogram
P743
Contrast study of the bladder
Define the following terms:
Ureteral stents
P743
Plastic tubes placed via cystoscope into
the ureters for stenting, identification, etc.
Define the following terms:
Cystoscope
P743
Scope placed into the urethra and into
the bladder to visualize the bladder
Define the following terms:
Perc nephrostomy
P743
Catheter placed through the skin into the
kidney pelvis to drain urine with distal
obstruction, etc.
Define the following terms:
Retrograde pyelogram
P743
Dye injected into the ureter up into the
kidney, and films taken
Define the following terms:
RUG
P744
Retrograde UrethroGram (dye injected into the urethra and films taken; rules out urethral injury, usually in trauma patients)
Define the following terms:
Gomco clamp
P744
Clamp used for circumcision; protects
penis glans
Define the following terms:
Bell clapper’s deformity
P744
Condition of congenital absence of
gubernaculum attachment to scrotum
Define the following terms:
Fournier’s gangrene
P744
Extensive tissue necrosis/infection of the
perineum in patients with diabetes
Define the following terms:
Foley catheter
P744
Straight bladder catheter placed through
the urethra
Define the following terms:
Coudé catheter
P744
Basically, a Foley catheter with hook on
the end to get around a large prostate
Define the following terms:
Suprapubic catheter
P744
Bladder catheter placed through the skin
above the pubic symphysis into the bladder
Define the following terms:
Posthitis
P744
Foreskin infection
Define the following terms:
Hydrocele
P744
Clear fluid in the processus vaginalis
membrane
Define the following terms:
Communicating
hydrocele
P744 (picture)
Hydrocele that communicates with
peritoneal cavity and, thus, gets smaller
and larger as fluid drains and then
reaccumulates
Define the following terms:
Noncommunicating
hydrocele
P745 (picture)
Hydrocele that does not communicate
with the peritoneal cavity; hydrocele
remains the same size
Define the following terms:
Varicocele
P745
Abnormal dilation of the pampiniform
plexus to the spermatic vein in the spermatic
cord; described as a “bag of worms”
Define the following terms:
Spermatocele
P745
Dilatation of epididymis or vas deferens
Define the following terms:
Epididymitis
P745
Infection of the epididymis
Define the following terms:
Prehn’s sign
P745
Elevation of the painful testicle that
reduces the pain of epididymitis
Define the following terms:
TRUS
P745
TransRectal UltraSound
Define the following terms:
DRE
P745
Digital Rectal Examination
Define the following terms:
Orchitis
P745
Inflammation/infection of the testicle
Define the following terms:
Pseudohermaphroditism
P745
Genetically one sex; partial or complete
opposite-sex genitalia
Define the following terms:
Urgency
P745
Overwhelming sensation to void
immediately
Define the following terms:
Dysuria
P745
Painful urination (usually burning sensation)
Define the following terms:
Frequency
P745
Urination more frequently than usual
Define the following terms:
Polyuria
P746
Urination in larger amounts than usual
Define the following terms:
Nocturia
P746
Awakening to urinate
Define the following terms:
Hesitancy
P746
Delay in urination
Define the following terms:
Pneumaturia
P746
Air passed with urine via the urethra
Define the following terms:
Pyuria
P746
WBCs in urine; UTI >10 WBCs/HPF
Define the following terms:
Cryptorchidism
P746
Undescended testicle
Define the following terms:
IVP
P746
IntraVenous Pyelogram (dye is injected into the vein, collects in the renal collecting system, and an x-ray is taken)
Define the following terms:
Hematuria
P746
RBCs in urine
Define the following terms:
Space of Retzius
P746
Anatomic extraperitoneal space in front
of the bladder
Define the following terms:
Enuresis
P746
Involuntary urination while asleep
Define the following terms:
Incontinence
P746
Involuntary urination
Define the following terms:
TURP
P746
TransUrethral Resection of the Prostate
Define the following terms:
PVR
P746
PostVoid Residual
Define the following terms:
Priapism
P746
Prolonged, painful erection
Define the following terms:
Paraphimosis
P746
Foreskin held (stuck) in the retracted position
Define the following terms:
Phimosis
P746
Inability to retract the foreskin
Define the following terms:
Balanitis
P746
Inflammation/infection of the glans penis
Define the following terms:
Balanoposthitis
P746
Inflammation/infection of the glans and
prepuce of the penis
Define the following terms:
UTI
P746
Urinary Tract Infection
Define the following terms:
Peyronie’s disease
P746
Abnormal fibrosis of the penis shaft,
resulting in a bend upon erection
Define the following terms:
BPH
P747
Benign Prostatic Hyperplasia
Define the following terms:
Epispadias
P747
Abnormal urethral opening on the dorsal
surface of the penis
Define the following terms:
Hypospadiasis
P747
Abnormal urethral opening on the
ventral surface of the penis; may occur in
anterior, middle, or posterior of penis
Define the following terms:
Erectile dysfunction
P747
Inability to achieve an erection
Define the following terms:
Sterility
P747
Inability to reproduce
Define the following terms:
Appendix testis
P747
Common redundant testicular tissue
Define the following terms:
VUR
P747
VesicoUreteral Reflux
SCROTAL ANATOMY
What are the layers of the
scrotum?
P747 (picture)
(see picture)
UROLOGIC DIFFERENTIAL DIAGNOSIS
What is the differential
diagnosis of scrotal mass?
P747 (picture)
Cancer, torsion, epididymitis, hydrocele,
spermatocele, varicocele, inguinal hernia,
testicular appendage, swollen testicle after
trauma, nontesticular tumor (paratesticular
tumor: e.g., rhabdomyosarcoma,
leiomyosarcoma, liposarcoma)
UROLOGIC DIFFERENTIAL DIAGNOSIS
What are the causes of
hematuria?
P748
Bladder cancer, trauma, UTI, cystitis
from chemotherapy or radiation, stones,
kidney lesion, BPH
UROLOGIC DIFFERENTIAL DIAGNOSIS What is the most common cause of severe gross hematuria without trauma or chemotherapy/radiation? P748
Bladder cancer
UROLOGIC DIFFERENTIAL DIAGNOSIS What is the differential diagnosis for bladder outlet obstruction? P748
BPH, stone, foreign body, urethral
stricture, urethral valve
UROLOGIC DIFFERENTIAL DIAGNOSIS What is the differential diagnosis for ureteral obstruction? P748
Stone, tumor, iatrogenic (suture),
stricture, gravid uterus, radiation injury,
retroperitoneal fibrosis
UROLOGIC DIFFERENTIAL DIAGNOSIS
What is the differential
diagnosis for kidney tumor?
P748
Renal cell carcinoma, sarcoma, adenoma,
angiomyolipoma, hemangiopericytoma,
oncocytoma
RENAL CELL CARCINOMA (RCC)
What is it?
P748
Most common solid renal tumor (90%);
originates from proximal renal tubular
epithelium
RENAL CELL CARCINOMA (RCC)
What is the epidemiology?
P748
Primarily a tumor of adults 40 to 60 years
of age with a 3:1 male:female ratio; 5% of
cancers overall in adults
RENAL CELL CARCINOMA (RCC)
What percentage of the
tumors are bilateral?
P748
1%
RENAL CELL CARCINOMA (RCC)
What are the risk factors?
P748
Male sex, tobacco, von Hippel-Lindau
syndrome, polycystic kidney
RENAL CELL CARCINOMA (RCC)
What are the symptoms?
P748
Pain (40%), hematuria (35%), weight loss
35%), flank mass (25%), HTN (20%
RENAL CELL CARCINOMA (RCC)
What is the classic TRIAD of
renal cell carcinoma?
P748
- Flank pain
- Hematuria
- Palpable mass (triad occurs in only
10%–15% of cases)
RENAL CELL CARCINOMA (RCC)
How are most cases
diagnosed these days?
P749
Found incidentally on an imaging study
(CT, MRI, U/S) for another reason
RENAL CELL CARCINOMA (RCC)
What radiologic tests are
performed?
P749
- IVP
2. Abdominal CT scan with contrast
RENAL CELL CARCINOMA (RCC)
Define the stages (AJCC):
Stage I?
P749
Tumor <2.5 cm, no nodes, no metastases
RENAL CELL CARCINOMA (RCC)
Define the stages (AJCC):
Stage II?
P749
Tumor >2.5 cm limited to kidney, no
nodes, no metastases
RENAL CELL CARCINOMA (RCC)
Define the stages (AJCC):
Stage III?
P749
Tumor extends into IVC or main renal
vein; positive regional lymph nodes but
<2 cm in diameter and no metastases
RENAL CELL CARCINOMA (RCC)
Define the stages (AJCC):
Stage IV?
P749
Distant metastasis or positive lymph node
>2 cm in diameter, or tumor extends past
Gerota’s fascia
RENAL CELL CARCINOMA (RCC)
What is the metastatic
workup?
P749
CXR, IVP, CT scan, LFTs, calcium
RENAL CELL CARCINOMA (RCC)
What are the sites of
metastases?
P749
Lung, liver, brain, bone; tumor thrombus
entering renal vein or IVC is not
uncommon
RENAL CELL CARCINOMA (RCC)
What is the unique route of
spread?
P749
Tumor thrombus into IVC lumen
RENAL CELL CARCINOMA (RCC)
What is the treatment of
RCC?
P749
Radical nephrectomy (excision of the
kidney and adrenal, including Gerota’s
fascia) for stages I through IV
RENAL CELL CARCINOMA (RCC)
What gland is removed with
a radical nephrectomy?
P749
Adrenal gland
RENAL CELL CARCINOMA (RCC) What is the unique treatment for metastatic spread? P749
- a-interferon
- LAK cells (lymphokine-activated
killer) and IL-2 (interleukin-2)
RENAL CELL CARCINOMA (RCC)
What is a syndrome of RCC
and liver disease?
P749
Stauffer’s syndrome
RENAL CELL CARCINOMA (RCC) What is the concern in an adult with new onset left varicocele? P750
Left RCC—the left gonadal vein drains
into the left renal vein
BLADDER CANCER
What is the incidence?
P750
Second most common urologic malignancy
Male:female ratio of 3:1
White patients are more commonly affected
than are African American patients
BLADDER CANCER
What is the most common
histology?
P750
Transitional Cell Carcinoma (TCC)—
90%; remaining cases are squamous or
adenocarcinomas
BLADDER CANCER
What are the risk factors?
P750
Smoking, industrial carcinogens (aromatic
amines), schistosomiasis, truck drivers,
petroleum workers, cyclophosphamide
BLADDER CANCER
What are the symptoms?
P750
Hematuria, with or without irritative
symptoms (e.g., dysuria), frequency
BLADDER CANCER
What is the classic presentation
of bladder cancer?
P750
“Painless hematuria”
BLADDER CANCER
What tests are included in
the workup?
P750
Urinalysis and culture, IVP, cystoscopy
with cytology and biopsy
BLADDER CANCER Define the AJCC transitional cell bladder cancer stages: Stage 0? P750
Superficial, carcinoma in situ
BLADDER CANCER Define the AJCC transitional cell bladder cancer stages: Stage I? P750
Invades subepithelial connective tissue,
no positive nodes, no metastases
BLADDER CANCER Define the AJCC transitional cell bladder cancer stages: Stage II? P750
Invades superficial or deep muscularis
propria, no positive nodes, no metastases
BLADDER CANCER Define the AJCC transitional cell bladder cancer stages: Stage III? P750
Invades perivesical tissues, no positive
nodes, no metastases
BLADDER CANCER Define the AJCC transitional cell bladder cancer stages: Stage IV? P750
Positive nodal spread with distant
metastases and/or invades abdominal/
pelvic wall
BLADDER CANCER What is the treatment according to stage: Stage 0? P751
TURB and intravesical chemotherapy
BLADDER CANCER What is the treatment according to stage: Stage I? P751
TURB
BLADDER CANCER What is the treatment according to stage: Stage II and III? P751
Radical cystectomy, lymph node
dissection, removal of prostate/uterus/
ovaries/anterior vaginal wall, and urinary
diversion (e.g., ileal conduit) +/- chemo
BLADDER CANCER What is the treatment according to stage: Stage IV? P751
+/- Cystectomy and systemic
chemotherapy
BLADDER CANCER
What are the indications for
a partial cystectomy?
P751
Superficial, isolated tumor, apical with
3-cm margin from any orifices
BLADDER CANCER
What is TURB?
P751
TransUrethral Resection of the Bladder
BLADDER CANCER
If after a TURB the tumor
recurs, then what?
P751
Repeat TURB and intravesical
chemotherapy (mitomycin C) or
bacillus Calmette-Guérin
BLADDER CANCER
What is and how does bacillus
Calmette-Guérin work?
P751
Attenuated TB vaccine—thought to work
by immune response
PROSTATE CANCER
What is the incidence?
P751
Most common GU cancer (100,000 new cases per year in the United States); most common carcinoma in men in the U.S.; second most common cause of death in men in the U.S.
PROSTATE CANCER
What is the epidemiology?
P751
“Disease of elderly men” present in 33% of men 70 to 79 years of age and in 66% of men 80 to 89 years of age at autopsy; African American patients have a 50% higher incidence than do white patients
PROSTATE CANCER
What is the histology?
P751
Adenocarcinoma (95%)
PROSTATE CANCER
What are the symptoms?
P752
Often asymptomatic; usually presents as a nodule found on routine rectal examination; in 70% of cases, cancer begins in the periphery of the gland and moves centrally; thus, obstructive symptoms occur late
PROSTATE CANCER
What percentage of patients
have metastasis at diagnosis?
P752
40% of patients have metastatic disease
at presentation, with symptoms of bone
pain and weight loss
PROSTATE CANCER
What are the common sites
of metastasis?
P752
Osteoblastic bony lesions, lung, liver,
adrenal
PROSTATE CANCER
What provides lymphatic
drainage?
P752
Obturator and hypogastric nodes
PROSTATE CANCER
What is the significance of
Batson’s plexus?
P752
Spinal cord venous plexus; route of
isolated skull/brain metastasis
PROSTATE CANCER
What are the steps in early
detection?
P752
- Prostate-specific antigen (PSA)—most
sensitive and specific marker - Digital rectal examination (DRE)
PROSTATE CANCER
When should men get a
PSA-level check?
P752
Controversial:
1. All men >50 years old
2. >40 years old if first-degree family
history or African American patient
PROSTATE CANCER What percentage of patients with prostate cancer will have an elevated PSA? P752
≈60%
PROSTATE CANCER
What is the imaging test for
bladder cancer?
P752
TransRectal UltraSound (TRUS)
PROSTATE CANCER
How is the diagnosis made?
P752
Transrectal biopsy
PROSTATE CANCER
What is the Gleason score?
P752
Histologic grades 2–10:
Low score = well differentiated
High score = poorly differentiated
PROSTATE CANCER What are the indications for transrectal biopsy with normal rectal examination? P752
PSA >10 or abnormal transrectal
ultrasound
PROSTATE CANCER
Staging (AJCC):
Stage I?
P753
Tumor involves <50% of 1 lobe, no nodes,
no metastases, PSA 10, Gleason ≤6
PROSTATE CANCER
Staging (AJCC):
Stage II?
P753
Tumor within prostate; lobe 10, or Gleason >6; or >50% of
1 lobe, no nodes, no metastases
PROSTATE CANCER
Staging (AJCC):
Stage III?
P753
Tumor through prostate capsule or into
seminal vesicles, no nodes, no metastases
PROSTATE CANCER
Staging (AJCC):
Stage IV?
P753
Tumor extends into adjacent structures
(other than seminal vesicles) or + nodes
or + metastases
PROSTATE CANCER
What does a “radical
prostatectomy” remove?
P753
- Prostate gland
- Seminal vesicles
- Ampullae of the vasa deferentia
PROSTATE CANCER
What is “androgen ablation”
therapy?
P753
- Bilateral orchiectomy or
- Luteinizing Hormone-Releasing
Hormone (LHRH) agonists
PROSTATE CANCER
How do LHRH agonists
work?
P753
Decrease LH release from pituitary,
which then decreases testosterone
production in the testes
PROSTATE CANCER What are the generalized treatment options according to stage: Stage I? P753
Radical prostatectomy
PROSTATE CANCER What are the generalized treatment options according to stage: Stage II? P753
Radical prostatectomy, +/- lymph node
dissection
PROSTATE CANCER What are the generalized treatment options according to stage: Stage III? P753
Radiation therapy, +/- androgen ablation
PROSTATE CANCER What are the generalized treatment options according to stage: Stage IV? P753
Androgen ablation, radiation therapy
PROSTATE CANCER What is the medical treatment for systemic metastatic disease? P753
Androgen ablation
PROSTATE CANCER What is the option for treatment in the early stage prostate cancer patient >70 years old with comorbidity? P754
XRT
BENIGN PROSTATIC HYPERPLASIA
What is it also known as?
P754
BPH
BENIGN PROSTATIC HYPERPLASIA
What is it?
P754
Disease of elderly men (average age is
60 to 65 years); prostate gradually
enlarges, creating symptoms of urinary
outflow obstruction
BENIGN PROSTATIC HYPERPLASIA
What is the size of a normal
prostate?
P754
20 to 25 gm
BENIGN PROSTATIC HYPERPLASIA
Where does BPH occur?
P754
Periurethrally
(Note: prostate cancer occurs in the
periphery of the gland)
BENIGN PROSTATIC HYPERPLASIA
What are the symptoms?
P754
Obstructive-type symptoms: hesitancy,
weak stream, nocturia, intermittency,
UTI, urinary retention
BENIGN PROSTATIC HYPERPLASIA
How is the diagnosis made?
P754
History, DRE, elevated PostVoid Residual
(PVR), urinalysis, cystoscopy, U/S
BENIGN PROSTATIC HYPERPLASIA
What lab tests should be
performed?
P754
Urinalysis, PSA, BUN, CR
BENIGN PROSTATIC HYPERPLASIA
What is the differential
diagnosis?
P754
Prostate cancer (e.g., nodular)—biopsy Neurogenic bladder—history of neurologic disease Acute prostatitis—hot, tender gland Urethral stricture—RUG, history of STD Stone UTI
BENIGN PROSTATIC HYPERPLASIA
What are the treatment
options?
P754
Pharmacologic— a-1 blockade Hormonal—antiandrogens Surgical—TURP, TUIP, open prostate resection Transurethral balloon dilation
BENIGN PROSTATIC HYPERPLASIA
Why do -adrenergic
blockers work?
P755
- Relax sphincter
2. Relax prostate capsule
BENIGN PROSTATIC HYPERPLASIA
What is Proscar®?
P755
Finasteride: 5--reductase inhibitor;
blocks transformation of testosterone to
dihydrotestosterone; may shrink and slow
progression of BPH
BENIGN PROSTATIC HYPERPLASIA
What is Hytrin®?
P755
Terazosin: -blocker; may increase urine
outflow by relaxing prostatic smooth
muscles
BENIGN PROSTATIC HYPERPLASIA
What are the indications for
surgery in BPH?
P755
Due to obstruction: Urinary retention Hydronephrosis UTIs Severe symptoms
BENIGN PROSTATIC HYPERPLASIA
What is TURP?
P755
TransUrethral Resection of Prostate:
resection of prostate tissue via a scope
BENIGN PROSTATIC HYPERPLASIA
What is TUIP?
P755
TransUrethral Incision of Prostate
BENIGN PROSTATIC HYPERPLASIA What percentage of tissue removed for BPH will have malignant tissue on histology? P755
Up to 10%!
BENIGN PROSTATIC HYPERPLASIA
What are the possible
complications of TURP?
P755
Immediate: Failure to void Bleeding Clot retention UTI Incontinence
TESTICULAR CANCER
What is the incidence?
P755
Rare; 2 to 3 new cases per 100,000 men
per year in the United States
TESTICULAR CANCER
What is its claim to fame?
P755
Most common solid tumor of young adult
males (20 to 40 years)
TESTICULAR CANCER
What are the risk factors?
P755
Cryptorchidism (6% of testicular tumors
develop in patients with a history of
cryptorchidism)
TESTICULAR CANCER
What is cryptorchidism?
P756
Failure of the testicle to descend into the
scrotum
TESTICULAR CANCER Does orchiopexy as an adult remove the risk of testicular cancer? P756
NO
TESTICULAR CANCER
What are the symptoms?
P756
Most patients present with a painless lump,
swelling, or firmness of the testicle; they often
notice it after incidental trauma to the groin
TESTICULAR CANCER What percentage of patients present with an acute hydrocele? P756
10%
TESTICULAR CANCER What percentage present with symptoms of metastatic disease (back pain, anorexia)? P756
≈10%
TESTICULAR CANCER
What are the classifications?
P756
Germ cell tumors (95%): Seminomatous (35%) Nonseminomatous (65%) Embryonal cell carcinoma Teratoma Mixed cell Choriocarcinoma Nongerminal (5%): Leydig cell Sertoli cell Gonadoblastoma
TESTICULAR CANCER
What is the major classification
based on therapy?
P756
Seminomatous and nonseminomatous
tumors
TESTICULAR CANCER
What are the tumor markers
for testicular tumors?
P756
- Beta-human chorionic gonadotropin
( ℬ-HCG) - Alpha-fetoprotein (AFP)
TESTICULAR CANCER
What are the tumor markers
by tumor type?
P756
ℬ-HCG—↑ in choriocarcinoma (100%), embryonal carcinoma (50%), and rarely in pure seminomas (10%); nonseminomatous tumors (50%) AFP—↑ in embryonal carcinoma and yolk sac tumors; nonseminomatous tumors (50%)
TESTICULAR CANCER Define the difference between seminomatous and NONseminomatous germ cell testicular tumor markers. P757
NONseminomatous common = 90%
have a positive AFP and/or ℬ-HCG
Seminomatous rare = only 10% are
AFP positive
TESTICULAR CANCER
Which tumors almost never
have an elevated AFP?
P757
Choriocarcinoma and seminoma
TESTICULAR CANCER
In which tumor is -HCG
almost always found elevated?
P757
Choriocarcinoma
TESTICULAR CANCER How often is -HCG elevated in patients with pure seminoma? P757
Only about 10% of the time!
TESTICULAR CANCER
How often is -HCG elevated
with nonseminoma?
P757
≈65%
TESTICULAR CANCER What other tumor markers may be elevated and useful for recurrence surveillance? P757
LDH, CEA, Human Chorionic
Somatomammotropic (HCS),
Gamma-Glutamyl Transpeptidase (GGT),
PLacental Alkaline Phosphate (PLAP)
TESTICULAR CANCER
What are the steps in
workup?
P757
PE, scrotal U/S, check tumor markers,
CXR, CT (chest/pelvis/abd)
TESTICULAR CANCER Define the stages according to TMN staging (AJCC): Stage I? P757
Any tumor size, no nodes, no metastases
TESTICULAR CANCER Define the stages according to TMN staging (AJCC): Stage II? P757
Positive nodes, no metastases, any tumor
TESTICULAR CANCER Define the stages according to TMN staging (AJCC): Stage III? P757
Distant metastases (any nodal status, any size tumor)
TESTICULAR CANCER
What is the initial treatment
for all testicular tumors?
P757
Inguinal orchiectomy (removal of testicle through a groin incision)
TESTICULAR CANCER What is the treatment of seminoma at the various stages: Stage I and II? P757
Inguinal orchiectomy and radiation to
retroperitoneal nodal basins
TESTICULAR CANCER What is the treatment of seminoma at the various stages: Stage III? P757
Orchiectomy and chemotherapy
TESTICULAR CANCER What is the treatment of NONseminomatous disease at the various stages: Stages I and II? P758
Orchiectomy and retroperitoneal lymph
node dissection versus close follow-up
for retroperitoneal nodal involvement
TESTICULAR CANCER What is the treatment of NONseminomatous disease at the various stages: Stages III? P758
Orchiectomy and chemotherapy
TESTICULAR CANCER What percentage of stage I seminomas are cured after treatment? P758
95%
TESTICULAR CANCER
Which type is most
radiosensitive?
P758
Seminoma (Think: Seminoma = Sensitive
to radiation)
TESTICULAR CANCER Why not remove testis with cancer through a scrotal incision? P758
It could result in tumor seeding of the
scrotum
TESTICULAR CANCER What is the major side effect of retroperitoneal lymph node dissection? P758
Erectile dysfunction
TESTICULAR TORSION
What is it?
P758
Torsion (twist) of the spermatic cord,
resulting in venous outflow obstruction,
and subsequent arterial occlusion →
infarction of the testicle
TESTICULAR TORSION
What is the classic history?
P758
Acute onset of scrotal pain usually after
vigorous activity or minor trauma
TESTICULAR TORSION
What is a “bell clapper”
deformity?
P758 (picture)
Bilateral nonattachment of the testicles
by the gubernaculum to the scrotum
(free like the clappers of a bell)
TESTICULAR TORSION
What are the symptoms?
P759
Pain in the scrotum, suprapubic pain
TESTICULAR TORSION
What are the signs?
P759
Very tender, swollen, elevated testicle;
nonillumination; absence of cremasteric
reflex
TESTICULAR TORSION
What is the differential
diagnosis?
P759
Testicular trauma, inguinal hernia,
epididymitis, appendage torsion
TESTICULAR TORSION
How is the diagnosis made?
P759
Surgical exploration, U/S (solid mass) and
Doppler flow study, cold Tc-99m scan
(nuclear study)
TESTICULAR TORSION
What is the treatment?
P759
Surgical detorsion and bilateral orchiopexy
to the scrotum
TESTICULAR TORSION How much time is available from the onset of symptoms to detorse the testicle? P759
90% salvage rate
TESTICULAR TORSION
What are the chances of testicle
salvage after 24 hours?
P759
<10%
EPIDIDYMITIS
What is it?
P759
Infection of the epididymis
EPIDIDYMITIS
What are the
signs/symptoms?
P759
Swollen, tender testicle; dysuria; scrotal
ache/pain; fever; chills; scrotal mass
EPIDIDYMITIS
What is the cause?
P759
Bacteria from the urethra
EPIDIDYMITIS What are the common bugs in the following types of patients: Elderly patients/children? P759
Escherichia coli
EPIDIDYMITIS What are the common bugs in the following types of patients: Young men? P759
STD bacteria: Gonorrhea, chlamydia
EPIDIDYMITIS
What is the major
differential diagnosis?
P759
Testicular torsion
EPIDIDYMITIS
What is the workup?
P759
U/A, urine culture, swab if STD suspected,
+/- U/S with Doppler or nuclear study
to rule out torsion
EPIDIDYMITIS
What is the treatment?
P759
Antibiotics
PRIAPISM
What is priapism?
P760
Persistent penile erection
PRIAPISM
What are its causes?
P760
Low flow: leukemia, drugs (e.g., prazosin),
sickle-cell disease, erectile dysfunction
treatment gone wrong
High flow: pudendal artery fistula, usually
from trauma
PRIAPISM
What is first-line treatment?
P760
- Aspiration of blood from corporus
cavernosum - -Adrenergic agent
ERECTILE DYSFUNCTION
What is it?
P760
Inability to achieve an erection
ERECTILE DYSFUNCTION
What are the six major
causes?
P760
1. Vascular: decreased blood flow or leak of blood from the corpus cavernosus (most common cause) 2. Endocrine: low testosterone 3. Anatomic: structural abnormality of the erectile apparatus (e.g., Peyronie’s disease) 4. Neurologic: damage to nerves (e.g., postoperative, IDDM) 5. Medications (e.g., clonidine) 6. Psychologic: performance anxiety, etc. (very rare)
ERECTILE DYSFUNCTION
What lab tests should be
performed?
P760
Fasting GLC (rule out diabetes and thus
diabetic neuropathy)
Serum testosterone
Serum prolactin
CALCULUS DISEASE
What is the incidence?
P760
1 in 10 people will have stones
CALCULUS DISEASE
What are the risk factors?
P760
Poor fluid intake, IBD, hypercalcemia
(“CHIMPANZEES”), renal tubular
acidosis, small bowel bypass
CALCULUS DISEASE
What are the four types of
stones?
P761
- Calcium oxalate/calcium PO(4) (75%)—
secondary to hypercalciuria (↑ intestinal
absorption, ↓ renal reabsorption,
↑ bone reabsorption) - Struvite (MgAmPh)(15%)—infection
stones; seen in UTI with urea-splitting
bacteria (Proteus); may cause staghorn
calculi; high urine pH - Uric acid (7%)—stones are radiolucent
(Think: Uric = Unseen); seen in gout,
Lesch-Nyhan, chronic diarrhea,
cancer; low urine pH - Cystine (1%)—genetic predisposition
CALCULUS DISEASE
What type of stones are not
seen on AXR?
P761
Uric acid (Think: Uric = Unseen)
CALCULUS DISEASE
What stone is associated
with UTIs?
P761
Struvite stones (Think: Struvite = Sepsis)
CALCULUS DISEASE
What stones are seen in
IBD/bowel bypass?
P761
Calcium oxalate
CALCULUS DISEASE
What are the symptoms of
calculus disease?
P761
Severe pain; patient cannot sit still: renal
colic (typically pain in the kidney/ureter
that radiates to the testis or penis),
hematuria (remember, patients with
peritoneal signs are motionless)
CALCULUS DISEASE
What are the classic
findings/symptoms?
P761
Flank pain, stone on AXR, hematuria
CALCULUS DISEASE
Diagnosis?
P761
KUB (90% radiopaque), IVP, urinalysis
and culture, BUN/Cr, CBC
CALCULUS DISEASE
What is the significance of
hematuria and pyuria?
P761
Stone with concomitant infection
CALCULUS DISEASE
Treatment?
P761
Narcotics for pain, vigorous hydration, observation Further options: ESWL (lithotripsy), ureteroscopy, percutaneous lithotripsy, open surgery; metabolic workup for recurrence
CALCULUS DISEASE
What are the indications for
intervention?
P762
Urinary tract obstruction
Persistent infection
Impaired renal function
CALCULUS DISEASE What are the contraindications of outpatient treatment? P762
Pregnancy, diabetes, obstruction, severe
dehydration, severe pain, urosepsis/fever,
pyelonephritis, previous urologic surgery,
only one functioning kidney
CALCULUS DISEASE
What are the three common
sites of obstruction?
P762
- UreteroPelvic Junction (UPJ)
- UreteroVesicular Junction (UVJ)
- Intersection of the ureter and the iliac
vessels
INCONTINENCE
What are the common types
of incontinence?
P762
Stress incontinence, overflow
incontinence, urge incontinence
INCONTINENCE
Define the following terms:
Stress incontinence
P762
Loss of urine associated with coughing,
lifting, exercise, etc.; seen most often in
women, secondary to relaxation of pelvic
floor following multiple deliveries
INCONTINENCE
Define the following terms:
Overflow incontinence
P762
Failure of the bladder to empty properly;
may be caused by bladder outlet
obstruction (BPH or stricture) or
detrusor hypotonicity
INCONTINENCE
Define the following terms:
Urge incontinence
P762
Loss of urine secondary to detrusor
instability in patients with stroke,
dementia, Parkinson’s disease, etc.
INCONTINENCE
Define the following terms:
Mixed incontinence
P762
Stress and urge incontinence combined
INCONTINENCE
Define the following terms:
Enuresis
P762
Bedwetting in children
INCONTINENCE
Define the following terms:
How is the diagnosis made?
P762
History (including meds), physical examination (including pelvic/rectal examination), urinalysis, postvoid residual (PR), urodynamics, cystoscopy/ vesicocystourethrogram (VCUG) may be necessary
INCONTINENCE
What is the “Marshall test”?
P763
Woman with urinary stress incontinence
placed in the lithotomy position with a
full bladder leaks urine when asked to
cough
INCONTINENCE What is the treatment of the following disorders: Stress incontinence? P763
Bladder neck suspension
INCONTINENCE What is the treatment of the following disorders: Urge incontinence? P763
Pharmacotherapy (anticholinergics,
Ə-agonists)
INCONTINENCE What is the treatment of the following disorders: Overflow incontinence? P763
Self-catheterization, surgical relief of
obstruction, -blockers
URINARY TRACT INFECTION (UTI)
What is the aetiology?
P763
Ascending infection, instrumentation,
coitus in females
URINARY TRACT INFECTION (UTI)
What are the three common
organisms?
P763
- E. coli (90%)
- Proteus
- Klebsiella, Pseudomonas
URINARY TRACT INFECTION (UTI)
What are the predisposing
factors?
P763
Stones, obstruction, reflux, diabetes
mellitus, pregnancy, indwelling catheter/
stent
URINARY TRACT INFECTION (UTI)
What are the symptoms?
P763
Lower UTI—frequency, urgency, dysuria,
nocturia
Upper UTI—back/flank pain, fever, chills
URINARY TRACT INFECTION (UTI)
How is the diagnosis made?
P763
Symptoms, urinalysis ( >10 WBCs/HPF,
>105 CFU)
URINARY TRACT INFECTION (UTI)
When should workup be
performed?
P763
After first infection in male patients
(unless Foley is in place)
After first pyelonephritis in prepubescent
female patients
URINARY TRACT INFECTION (UTI)
What is the treatment?
P763
Lower: 1 to 4 days of oral antibiotics
Upper: 3 to 7 days of IV antibiotics
MISCELLANEOUS UROLOGY QUESTIONS
Why should orchiopexy be
performed?
P764
↓ the susceptibility to blunt trauma
↑ the ease of follow-up examinations
MISCELLANEOUS UROLOGY QUESTIONS
In which area of the
prostate does BPH arise?
P764
Periurethral
MISCELLANEOUS UROLOGY QUESTIONS In which area of the prostate does prostate cancer arise? P764
Periphery
MISCELLANEOUS UROLOGY QUESTIONS What type of bony lesions is seen in metastatic prostate cancer? P764
Osteoblastic (radiopaque)
MISCELLANEOUS UROLOGY QUESTIONS What percentage of renal cell carcinoma show evidence of metastatic disease at presentation? P764
≈33%
MISCELLANEOUS UROLOGY QUESTIONS What is the most common site of distant metastasis in renal cell carcinoma? P764
Lung
MISCELLANEOUS UROLOGY QUESTIONS What is the most common solid renal tumor of childhood? P764
Wilms’ tumor
MISCELLANEOUS UROLOGY QUESTIONS
What type of renal stone is
radiolucent?
P764
Uric acid (Think: Uric = Unseen)
MISCELLANEOUS UROLOGY QUESTIONS
What are posterior urethral
valves?
P764
Most common obstructive urethral lesion
in infants and newborns; occurs only in
males; found at the distal prostatic urethra
MISCELLANEOUS UROLOGY QUESTIONS
What is the most common
intraoperative bladder tumor?
P764
Foley catheter—don’t fall victim!
MISCELLANEOUS UROLOGY QUESTIONS What provides drainage of the left gonadal (e.g., testicular) vein? P764
Left renal vein
MISCELLANEOUS UROLOGY QUESTIONS
What provides drainage of
the right gonadal vein?
P765
IVC
MISCELLANEOUS UROLOGY QUESTIONS What are the signs of urethral injury in the trauma patient? P765
“High-riding, ballottable” prostate, blood
at the urethral meatus, severe pelvic
fracture, ecchymosis of scrotum
MISCELLANEOUS UROLOGY QUESTIONS What is the evaluation for urethral injury in the trauma patient? P765
RUG (Retrograde UrethroGram)
MISCELLANEOUS UROLOGY QUESTIONS What is the evaluation for a transected ureter intraoperatively? P765
IV indigo carmine and then look for leak
of blue urine in the operative field
MISCELLANEOUS UROLOGY QUESTIONS What aid is used to help identify the ureters in a previously radiated retroperitoneum? P765
Ureteral stents
MISCELLANEOUS UROLOGY QUESTIONS How can a small traumatic EXTRAperitoneal bladder rupture be treated? P765
Foley catheter
MISCELLANEOUS UROLOGY QUESTIONS How should a traumatic INTRAperitoneal bladder rupture be treated? P765
Operative repair
MISCELLANEOUS UROLOGY QUESTIONS What percentage of patients with an injured ureter will have no blood on urinalysis? P765
33%
MISCELLANEOUS UROLOGY QUESTIONS
What is the classic history
for papillary necrosis?
P765
Patient with diabetes taking NSAIDs or
patient with sickle cell trait
MISCELLANEOUS UROLOGY QUESTIONS
What is Fournier’s gangrene?
P765
Necrotizing fasciitis of perineum,
polymicrobial, diabetes = major risk
factor
MISCELLANEOUS UROLOGY QUESTIONS What unique bleeding problem can be seen with prostate surgery? P765
Release of TPA and urokinase (treat with
-aminocaproic acid)
MISCELLANEOUS UROLOGY QUESTIONS
What is the scrotal “blue
dot” sign?
P765
Torsed appendix testis
MISCELLANEOUS UROLOGY QUESTIONS
What is Peyronie’s disease?
P766
Curved penile orientation with erection
due to fibrosis of corpora cavernosa
MISCELLANEOUS UROLOGY QUESTIONS
What is a ureterocele?
P766
Dilation of the ureter—treat with
endoscopic incision or operative excision
MISCELLANEOUS UROLOGY QUESTIONS
What is a “three-way”
irrigating Foley catheter?
P766 (picture)
Foley catheter that irrigates and then
drains