Urology And Nephrology Flashcards
Upper Urinary Tract
Kidneys- nephrology
Production
Lower Urinary Tract
Bladder/urethra- urology
Storage
Functions of Kidney
Excrete waste Retrieve filtered particles Maintain acid/base balance Regulate BP Stimulate erythrocyte production
Definition of azotemia
Abnormal increase in the concentration of non-protein nitrogenous wastes (urea and creatinine) in blood
Pre-renal causes
Dehydration Hypoadrenocorticism Cardiac disease Shock Hypovolemia
Renal causes
(Parenchymal disease) Parenchymal disease Infections Cysts Inflammation Neoplasia Toxins
Post-renal causes
Obstructive
Blockage - urethral/bladder or urethral
T/F
Azotemia is not uremia
TRUE
Definition of Renal Failure
The clinical syndrome that occurs when kidneys are no longer able to maintain:
Regulatory function
Excretory function
Endocrine function
75 % of nephron population is non-functional
Renal Disease Definition
The presence of morphological or functional lesions in one or both kidneys, regardless of extent
Uremia definition
The constellation of clinical signs and biochemical abnormalities associated with critical loss of functional nephrons
The glomerular filtration rate is directly related to _____________
Renal functional mass
Gold Standard test for measuring glomerular function
Clearance of radioisotopes with renal scintigraphy
Urea is synthesized in the ______ and excreted by the _________
Liver; kidneys
Serum Urea levels are affected by
Species/age Liver function Dietary protein content Endogenous protein catabolism Renal function
Azotemia does not develop until GFR has decreased to ___________
25%
SDMA correlates highly with _____ by inulin and increases when there is a _______% decline in GFR
GFR ; 40
Gold standard for measuring urine concentration
Osmolality - measures number of particles in solution
Hyposthenuria
1.000-1.007
Isosthenuria
1.008-1.012
Minimally concentrated urine
1.013-1.030
Inadequately concentrated urine
1.013 < 1.022
Adequately concentrated urine
Dogs > 1.030
Cats > 1.035
Partial water deprivation test
maximal stimulation of ADH release will be present after loss of 5% body weight
Reference value for UPC
< 0.4 should be < 0.2
Hematuria
Presence of blood or red blood cells in the urine
Pseudohematuria
Red to brownish urine without intact RBCs
Causes of Hematuria
Systemic disorders
Renal
Bladder, ureter, urethra
Genital tract
Manifestations of renal disease
Systemic signs
Check for history of toxin exposure
Dehydration
Melena/hematemesis/vomiting
Urine production rate is
1-2 ml/kg/hr minimum
Renal carcinoma is more common in _________
Dogs (poor prognosis)
Renal lymphoma is more common in _______ and affects _________ kidneys
Cats ; both
Non-neoplastic causes of renomegaly
ACUTE URETERAL OBSTRUCTION Renal inflammation Amyloidosis Hydronephrosis Polycystic kidney disease Portosystemic shunt