Urology Flashcards
What are the LUTS?
Storage and voiding Sx due to LUT dysfunction
What is benign prostatic enlargement?
Enlarged prostate due to histological process of BPH
What is BPH?
Benign prostatic hyperplasia - histological diagnosis of BPE
What is bladder outflow obstruction?
Bladder outlet obstruction caused by BPE
Name the parts of the prostate
Transition zone
Peripheral zone
Central zone
Anterior firbomuscular zone
Where do cancers occur?
Peripheral zone
Where does BPH occur?
Transition zone
Why does BPH cause Sx before cancer?
Cancer is in peripheral zone which is further from urethra than transition zone - obstructs later on
Does prostate size correlate to cancer risk?
No
Are LUTS signs of prostate cancer?
No - occasionally they can be but rare
List the 7 components of International Prostate Scoring System
Freq, intermittency, urgency, weak stream, straining, nocturia, incomplete emptying
What else do you ask in urology Hx except IPSS?
How much do the LUTS affect your QoL?
List the voiding Sx
Hesitancy, weak stream, intermittency, incomplete emptying
List the storage Sx
Frequency, urgency, nocturia
What causes voiding problems?
Urethral stricture, BPH, bladder outflow obstruction
What causes storage Sx?
Detrusor overactivity
List risks of BPH
Older age, Afro Carribean
What exams must be done for someone with urology probelms?
Abdo and DRE
What Ix are done for pt with urology problems?
Urine dip Flow rate & postvoid residual bladder scan Blood tests (U&Es, PSA)
Conservative Mx for BPH/voiding Sx?
reassure, advice on reducing fluid intake in evening
Medical Mx for BPH/voiding Sx?
Alpha blocker - tamsulosin / alfuzosin
5 alpha reducatse inhibitor - finasteride
What health food supplement can help BPH?
Saw palmetto
Surgical Mx for BPH?
TURP - transurethral resection of prostate (cutting out channel in prostate for urine passage)
What is the alternative to surgical Mx of BPH?
Long term catheters
Conservative Mx for storage Sx?
Reassure, dietary advice (no coffee/acidy thing/spicy)
Bladder training exercises
Medical Mx for storage Sx?
Anticholinergics - oxybutinin, tolterodine, solifenacin
Beta agonists - betmiga
Surgical Mx for storage Sx?
Botox injections
Side effects of anticholengerics?
Dry mouth and eyes
What should you do in the event of urinary retention?
Catheterise & measure residual volume DRE Urine culture (+/- treat UTI) FBC, U&Es Neuro exam if ?cord compression
When would you admit someone with urinary retention?
If obstructive nephropathy suspected - need to monitor urine output & replace fluids
Where does prostate cancer rank in terms of most common male cancer?
1st
PC of prostate cancer?
Asymptomatic usually
LUTS, urinary retention, haematuria
Metastases - bone pain, FLAWS, spinal cord compression
How are most prostate cancers found?
PSA
Risk factors of prostate cancer
Age, afro Caribbean, FH, BRAC2 gene
Does PSA increase with age?
Yes
What is normal PSA for 70y/o?
7.2
What else increases PSA?
UTI, BPH, new catheterisation, urinary retention
Does a DRE raise PSA?
NO - raises it by 0.1 so not relevant
Are MRIs useful for prostate cancer?
Yes - good at differentiating between high and low risk (high risk shows, but low doesnt)
How do you diagnose prostate cancer?
TRUS biopsy - transrectal biopsy
What scoring system is used to rate how aggressive the cancer is?
Gleason
Which staging is invasive?
T3/4 as its invading outside the prostate capsule
How do you initially manage prostate cancer?
Stage with MRI
MDT discussion