Urology Flashcards
Name 3 storage LUTS and 4 voiding LUTS.
Storage= frequency, urgency, urge incontinence, nocturia Voiding= hesitancy, slow flow, terminal dribbling, haematuria, dysuria, incomplete voiding
Following taking a history of LUTS, name 3 important parts of the examination.
Abdominal examination- importantly noting bladder distension/palpable
Examine external genitalia- e.g. looking for phimosis or meatus stenosis
DRE
Give 3 investigations that may be used to investigate LUTS.
Uroflowmetry Bladder scan for post-void residual volume Urine dipstick MUS for culture and sensitivities PSA and renal function bloods Frequency volume chart Urodynamic testing US of kidney for hydronephrosis if renal function impaired or residual volume is high
Give 2 common causes of storage LUTS
and 2 common causes of voiding LUTS
Storage= overactive bladder, cystitis, bladder tumour, bladder calculi Voiding= BPE, prostate cancer, urethral stricutre, meatal stenosis, phimosis
What zone of the prostate does BPH usually arise?
Transitional zone
What does BPE feel like on DRE?
Soft enlarged gland
Which enzyme converts testosterone to its more potent form, DHT?
5-alpha reductase
How is testosterone linked to BPE?
DHT binds to receptors in the prostate gland, increasing secretions and possibly cell division, resulting in gland enlargement
What is first line medical therapy for BPE? Give an example drug and how it works.
Alpha blocker e.g. Tamsulosin.
Alpha 1 adrenoceptor antagonist, relaxes smooth muscle
What is second line medical therapy for BPE? Give example drug and how it works.
5-alpha reductase inhibitors e.g. Finasteride
Inhibits conversion of testosterone to dihydrotestosterone
What are 2 surgical management options for BPE?
TURP, laser prostatectomy, open prostatectomy, aquablation
Give 4 causes of a raised PSA.
Prostate cancer, BPE, UTI, prostatitis, urinary retention, catheterisation, ejaculation, exercise e.g. cycling
What is the most common type of prostate cancer?
Adenocarcinoma
75% of the time, prostate adenocarcinoma originates from what zone of the prostate?
Peripheral zone
True/false: adenocarcinoma of the prostate is multifocal 80% of the time.
True
What does prostate cancer feel like on DRE?
Craggy, hard, irregular gland
What investigations are used to further investigate prostate cancer following a raised PSA?
MRI, transrectal US guided biopsy, bone scan if bone mets suspected
What grading system is used for prostate cancer? What does it use to grade the cancer?
Gleason grading
Uses histology from prostatic biopsy
Where are the likely metastatic sites of prostate cancer?
Most frequently bone, then lung and liver
What is the management of low risk or intermediate risk localised prostate cancer?
Active surveillance or
Radical prostatectomy
Other than radical prostatectomy and active surveillance, outline other treatment options for prostate cancer.
Radiotherapy (brachytherapy and/or external beam radiation
Androgen deprivation therapy
Symptomatic e.g. bisphosphonates, ureter stent
What types of drugs are used in androgen deprivation therapy in prostate cancer?
LHRH antagonists or LHRH agonists
What risk prostate cancers is androgen deprivation therapy suitable for?
Intermediate, high risk and metastatic cancers
Give 3 risk factors for prostate cancer.
Age, family history, ethnicity (Afro-Caribbean), diet (high animal fat) and obesity, UV radiation
What does PSA do?
It’s a protease which prevents the coagulation of seminal fluid
Give 3 risks of a transrectal US guided biopsy of the prostate.
Infection Bleeding Discomfort Acute retention False negatives
What is taken out in a radical prostatectomy?
The prostate and seminal vesicles
Should an MRI for investigating prostate cancer be performed pre- or post-biopsy?
Pre. Can reduce the number of biopsies you perform and can increase accuracy of biopsies.
How do you get the Gleason score?
Histologically from biopsy. Add together the two most common scores e.g. 3+3= 6
How might prostatectomy affect the Gleason score?
There is a 30-40% risk of upgrading
How are Gleason grades now reported?
Gleason grade groups
True/false: a T1 stage prostate cancer is palpable?
False, it’s not palpable but picked up on PSA/MRI/biopsy
Who is active surveillance of prostate cancer for?
Men who want to defer radical treatment, those who have a low risk (sometimes intermediate risk) localised cancer.
Gleason grade 6 and 7 (grade group 1 and 2)
What investigations are involved in active surveillance of prostate cancer and how often?
3 monthly PSA
6 monthly DRE
TRUS and biopsy at 1 year
Who is watchful waiting of prostate cancer for?
What does it consist of?
Men who don’t wish to have radical treatment or who aren’t suitable for radical treatment
Observation and then deferred androgen deprivation therapy (if they develop symptoms or metastatic disease)
What are the 3 main side effects of external beam radiotherapy for prostate therapy?
LUTS, GI symptoms e.g. rectal discomfort/bleeding, ED
What are 2 CI to brachytherapy for prostate cancer?
Previous TURP (due to increased risk of incontinence)
Large prostate
Moderate to severe LUTS
Where in the body does androgen deprivation therapy medications act?
Anterior pituitary
Outline the treatment of metastatic prostate cancer.
Initially= androgen deprivation therapy
If good performance status, Docetaxel chemotherapy
Bone-targeted therapies e.g. zolendronic acid, denosumab, alpharadin
Palliative radiotherapy
Give 3 complications of metastatic prostate cancer.
Bone pain Fractures Hypercalcaemia Spinal cord compression Urinary retention Obstructive uropathy
How is spinal cord compression due to prostate cancer mets treated?
Dexamethasone + Omeprazole
Bed rest
Degarelix (LHRH antagonist)/Radiotherapy (if already on ADT)
May need to call neurosurgeons (if one level of compression)
How is obstructive uropathy caused by prostate cancer managed?
Nephrostomy or internal stents
If potassium is abnormal, correct medically
What causes bladder calculi to form?
Urinary stasis
Give 3 causes of bladder calculi
BPE, prostate cancer, weak detrusor muscle, long-term catheter
Bladder stones are most commonly made up of?
Calcium
Name 3 investigations that can be used to investigate bladder calculi.
US, X-ray, or flexible cystoscopy
Name 2 management options for bladder calculi.
Endoscopic e.g. cystolitholapaxy, laser fragmentation, pneumatic lithotripsy
Cystolithotomy (open removal of stone)
What is the most common histological subtype of bladder cancer?
Transitional cell carcinoma of the bladder
True/false: you can get adenocarcinoma of the bladder.
True- squamous cell carcinoma, adenocarcinoma and TCC
Name 4 risk factors for bladder cancer.
Age (50-80), male (2.5:1), Caucasian, exposure to dyes/paint/rubber/leather/textiles (aromatic amines are carcinogenic), smoking, FH, genetic conditions (HNPCC), Cyclophosphamide, previous pelvic radiotherapy.
Name 3 risk factors for squamous cell carcinoma of the bladder.
Smoking Schistosomiasis Chronic cystitis Long term catheter Intermittent self-catheterisation
What is the NICE 2WW referral guidelines for patients presenting with visible/invisible haematuria?
Patients >45 with visible haematuria and no UTI, or persists/recurs following proper treatment of UTI.
Or patient >60 with unexplained non-visible haematuria and either dysuria or raised WCC.
Give 3 blood tests you would request to investigate haematuria
FBC, clotting, U&Es, (Group and save if severe haematuria)
After bloods, what 2 investigations will all patients with haematuria require?
Imaging of the upper tracts (either US-KUB or CT with contrast)
Flexible cystoscopy
Give 2 reasons US-KUB is preferred in investigating haematuria compared to CT.
Give 1 disadvantage of US-KUB vs CT.
- Quick to do
- Doesn’t require contrast so can be done no matter the renal function
- No radiation exposure
DISADVANTAGE= user-dependent, so may miss small stones or tumours
What is the most common management method for bladder cancer?
TURBT
Chemotherapy for bladder cancer can be intra-vesical or systemic. Give 2 examples of drugs used intra-vesically.
BCG
Mitomycin C
Other than TURBT, what 2 surgical options are there for bladder cancer?
Cystodiathermy or laser
Cystectomy
A patient with haematuria needs continuous irrigation and bladder washouts. What type of catheter should you insert?
3-way catheter
Name 4 congenital abnormalities of the renal tract.
Pelvic ureteric junction obstruction Horseshoe kidney Renal agenesis and dysplasia Renal cysts Adult polycystic kidneys Ectopic kidney
PUJO increases the risk of what 3 things?
Infections, stones and renal failure
Patients with adult polycystic kidneys are at increased risk of a number of conditions. Name 3
Hypertension
Hepatic and pancreatic cysts
Intracranial aneurysms
Valve abnormalities (especially mitral valve prolapse)
What is the commonest renal tumour?
Renal cell carcinoma (adenocarcinoma)
What is the name of the cancer that arises from urothelial cells along the urinary tract?
Transitional cell carcinoma
What tumour is the commonest intra-abdominal tumour in children?
Wilms tumour/nephroblastoma.
Give 4 risk factors for renal cancer.
Smoking Age Male Obesity HTN CKD and dialysis Genetic e.g. von Hippel Lindau, HNPCC, HPRCC
How do most renal tumours present?
What is the classic triad?
Majority identified incidentally on imaging
Mass, haematuria and pain (fewer than 10% present with this)
Renal cancer may cause a left varicocele but wouldn’t cause a right varicocele. Why?
Left testicular vein drains into left renal vein, so involvement of the left renal vein would cause obstruction of the left testicular vein.
The right testicular vein drains directly into the IVC
What paraneoplastic syndromes might occur with renal carcinoma and why?
Polycythemia, due to paraneoplastic EPO production
Hypercalcaemia, due to excretion of PTH related hormone
Stauffer’s syndrome (abnormal LFTs)
Hypertension
Anaemia
Which renal tumour is radio-resistant?
Renal cell carcinoma
Surgical options for renal tumours can be full or partial nephrectomy.
What type of renal cancer would you perform a nephrouretectomy for?
When would you do renal artery embolisation?
Transitional cell carcinoma (because want to remove the ureters as well)
If unfit for surgery and refractory haematuria