Urology

Question 1

Doxazosin (Cardura, Doxadura)

Answer 1

Alpha-1 receptor blocker

Question 2

Mechanism of Doxazosin

Answer 2

Relaxes the muscles of blood vessel walls, muscles around the prostate gland and ladder exit

Question 3

Indications of Doxazosin

Answer 3

Hypertension

Benign Prostatic Hyperplasia

Question 4

Contraindications of Doxazosin

Answer 4

Urinary incontinence
Postural Hypotension 
Due to have cataract Surgery
Heart failure
Pulmonary oedema 
Elderly

Question 5

Side effects of Doxazosin

Answer 5

Incontinence in women, arrhythmias, asthenia, chest pain, cough, nausea and vomiting

Question 6

Interactions of Doxazosin

Answer 6

Any drugs reducing BP likely to increase the blood-pressure-lowering effect of Doxazosin

Question 7

Finasteride (Propecia, Proscar)

Answer 7

5-Alpha reductase inhibitor

Question 8

Mechanism of Finasteride

Answer 8

5-alpha reductase is present in muscle and converts testosterone to dihydrotestosterone (DHT). DHT is involved in BPH. Finasteride prevents conversion of testosterone.

Question 9

Indications of Finasteride

Answer 9

Benign Prostatic Hyperplasia

Alopecia in men

Question 10

Side effects of Finasteride

Answer 10

Increase risk of breast cancer
Breast swelling or tenderness
Impotence 
Decreased libido
Reduced ejaculate volume

Question 11

Elimination of Finasteride

Answer 11

• Excreted in semen nd can feminize male fetus so wear a condom if partner is likely to be pregnant
• Broken or crushed tablets are not to be handled by women who are pregnant as drug can be absorbed through skin

Question 12

Interactions of Finasteride

Answer 12

Interferes with Prostate Specific Antigen (PSA) screening test for prostate cancer