Urology Flashcards
causes of urinary tract obstruction?
Luminal:
stones, blood clots, sloughed papilla
Mural:
congenital / acquired stricture, tumour: renal, ureteric, bladder
neuromuscular dysfunction
extramural:
prostatic enlargement,
abdo/ pelvis mass/ tumour
retroperitoneal fibrosis
presentation of acute upper urinary tract obstruction?
loin pain -> groin
presentation of acute lower urinary tract obstruction?
bladder outflow obstruction precedes severe suprapubic pain w distended palpable bladder
presentation of chronic upper urinary tract obstruction?
flank pain
renal failure (may be polyuric)
presentation of chronic lower urinary tract obstruction?
frequency, hesitancy, poor stream, terminal dribbling, overflow incontinence
distended palpable bladder +/- large prostate PR
ix of urinary tract obstruction?
bloods: FBC, U+E
urine: dip, MCS
imaging:
US: hydronephrosis or hydroureter
Anterograde/ retrograde ureterograms: allow therapeutic drainage
radionucleotide imaging: renal function
CT/ MRI
mx of Upper urinary tract obstruction?
nephrostomy
ureteric stent
mx of lower urinary tract obstruction?
urethral or suprapubic catheter
complications of ureteric stents?
common:
infection, haematuria, trigonal irritation, encrustation
rare:
obstruction, ureteric rupture, stent migration
causes of urethral stricture?
trauma e.g. pelvic #, instrumentation
Infection e.g. gonorrhoea
Chemotx
balantitis xerotica obliterans (male lichen sclerosus)
presentation of urethral stricture?
hesitancy
poor stream
terminal dribbling
strangury: painful, frequent urination of small volumes that are expelled slowly only by straining and despite a severe sense of urgency, usually with the residual feeling of incomplete emptying.
pis-en-deux: residual urine results in a desire to pass urine soon after voiding
examination of urethral stricture?
PR: exclude prostatic cause
Palpate urethra through penis
examine meatus
ix of urethral stricture?
urodynamics:
decreased peak flow rate
increased micturation time
urethroscopy and cystoscopy
retrograde urethrogram
mx of urethral stricture?
internal urethrotomy
dilatation
stent
complications of obstructive uropathy?
Hyperkalaemia
metabolic acidosis
post-obstructive diuresis
Na and HCO3 losing nephropathy
infection
what is post obstructive diuresis?
Kidneys produce a lot of urine in the acute phase after relief of obstruction.
must keep up w losses to avoid dehydration
what is Na and HCO3 losing nephropathy following obstructive uropathy?
diuresis may -> loss of Na and HCO3
may require replacement with 1.26% NaHCO3
causes of urinary retention?
mechanical obstruction:
BPH
urethral stricture
clots, stones
constipation
dynamic obstruction: increased smooth muscle tone
post operative pain
drugs
neurological:
sensory/ motor innervation affected
pelvic surgery
MS
DM
spinal injury/ compression
myogenic:
overdistension of the bladder
Post-anaesthesia
High alcohol intake
features of acute urinary retention
suprapubic tenderness
palpable bladder: dull to percussion, cant get beneath it
large prostate on PR: check anal tone and sacral sensation
<1 L drained on catheterisation
imaging of acute urinary retention?
US: bladder volume, hydronephrosis
pelvic XR
mx of acute urinary retention?
analgesia
catheterise:
use correct catheter, e.g. 3 way if clots
+/- STAT gentamicin cover
hourly UO + replace: post obstruction diuresis
Tamsulosin: decreases risk of recatherisation after retention
TWOC after 24-72ha
presentation of chronic urinary retention?
insidious as bladder capacity increases (> 1.5L)
typically painless
overflow incontinence/ nocturnal enuresis
acute on chronic retention
lower abdo mass
UTI
renal failure
high vs low pressure chronic urinary retention?
high pressure:
high detrusor pressure @ end of micturition
typically bladder outflow obstruction ->
bilateral hydronephrosis and decreased renal function
Low pressure:
low detrusor pressure @ end of micturition
large volume retention w very compliant bladder
kidney able to excrete urine
no hydronephrosis -> normal renal function
mx of high pressure chronic urinary retention?
catheterise if
- renal impairment
- pain
- infection
Hourly UO + replace: post obstruction diuresis
consider TURP before TWOC
mx of low pressure chronic urinary retention?
avoid catheterisation if possible
-risk of introducing infection
early TURP
advantages of suprapubic catheterisation?
decreased UTI risk
decreased stricture formation
TWOC w/o catheter removal
Pt preference: increased comfort
maintain sexual function
disadvantages of suprapubic catheterisation?
More complex: need skills
serious complications can occur
contraindications of suprapubic catheterisation?
known or suspected bladder carcinoma
undiagnosed haematuria
previous lower abdo surgery
-> adhesion of small bowel to abdo wall
causes of false haematuria?
red urine
beetroot
rifampicin
porphyria
PV bleed
urethra causes of haematuria?
infection
trauma
stones
tumour
prostate causes of haematuria?
BPH
prostatitis
tumour
bladder causes of haematuria?
infection
stones
tumour
exercise
general causes of haematuria?
HSP
Bleeding diathesis
renal causes of haematuria?
infarct
trauma
infection
neoplasm
glomerulonephritis
polycystic kidneys
features of haematuria?
timing:
beginning of stream- urethral
throughout stream: renal/ systemic, bladder
end of stream: bladder stone, schistosomiasis
painful or painless?
obstructive symptoms?
systemic symptoms: weight loss, appetite
ix of haematuria?
Bloods: FBC, U+E, clotting
Urine: dip, MCS, cytology
Imaging: renal US, IVU, flexi cystoscopy + biopsy, CT/MRI, renal angio
what is periaortitis?
inflammatory condition which typically involves the infrarenal portion of the abdominal aorta.
various clinical presentations:
idiopathic retroperitoneal fibrosis
inflammatory AAA
perianeurysmal retroperitoneal fibrosis
isolated periaortitis
what is idiopathic retroperitoneal fibrosis?
autoimmune vasculitis
fibrinoid necrosis of vasa vasorum
affects aorta and small/medium sized retroperitoneal vessels
ureters are embedded in dense, fibrous tissue -> bilateral obstruction
associations of idiopathic retroperitoneal fibrosis?
drugs: BB, bromocriptine, methysergide, methyldopa
autoimmune disease: thyroiditis, SLE, ANCA+ vasculitis
smoking
asbestos
presentation of idiopathic retroperitoneal fibrosis?
middle aged male
vague loin, back or abdo pain
raised BP
chronic urinary tract obstruction
mx of idiopathic retroperitoneal fibrosis?
relieve obstruction: retrograde stent placement
ureterolysis: dissection of ureters from retroperitoneal tissue
+/- immunosuppression
ix of idiopathic retroperitoneal fibrosis?
bloods: raised urea and creatinine, raised ESP/CRP, low Hb
US: bilateral hydronephrosis + medial ureteric deviation
CT/MRI: peri aortic mass
biopsy: exclude Ca
pathophysiology of kidney stones?
increased concentration of urinary solute
decreased urine volume
urinary stasis
common anatomical sites for kidney stones?
pelviureteric junction
crossing iliac vessels at pelvic brim
under the vas or uterine artery
vesicoureteric junction
most common type of kidney stone?
calcium oxalate
urate kidney stones assoc w which condition?
gout
staghorn calculi
assoc w proteus infection
what type of kidney stone?
triple stones
ca, mg, ammonium - phosphate
cystine kidney stones
assoc w?
Fanconi syndrome
kidney stones associated factors??
dehydration
hypercalcaemia: primary hyperPTH, immobilisation
increased Oxalate excretion: tea, strawberries
UTIs
hyperuricaemia e.g. gout
urinary tract abnormalities e.g. bladder diverticulae
drugs: furosemide, thiazides
presentation of kidney stones?
severe loin pain radiating to groin
N+V
pt cannot lie still
may cause bladder/ urethral obstruction:
bladder irritability: frequency, dysuria, haematuria
strangury: painful urinary tenesmus
suprapubic pain radiating -> tip of penis or in labia
pain and haematuria worse at end of micturition
ix of kidney stones?
urine: dip - haematuria, MCS
bloods: FBC, U+E, Ca, PO4, urate
imaging: CT KUB gold standard,
USS may show hydronephrosis
prevention of kidney stones?
drink plenty
treat UTIs rapidly
decreased oxalate intake: chocolate, tea, strawberries
indications for conservative tx of kidney stones?
stone < 5mm in size
and in lower 1/3 of ureter
conservative mx of kidney stones?
give all analgesia e.g. diclofenac or opioids
fluids: IV if unable to tolerate PO
abx if infection: e.g. cefuroxime
90-95% pass stone spontaneously
can discharge pt w analgesia
sieve urine to collect stone for OPD analysis
indications of medical expulsive therapy for kidney stones?
stone 5-10 mm
stone expected to pass
what is medical expulsive therapy for kidney stones?
Nifedipine or tamsulosin (alpha blocker)
+/- prednisolone
indications for active stone removal of kidney stones?
low likelihood of spontaneous passage e.g. > 10 mm
persistent obstruction
renal insufficiency
infection
indications for percutaneous nephrolithotomy?
1st line if stone > 20mm in renal pelvis
e.g. staghorn calculi
indications for extracorporeal shockwave lithotripsy?
1st line for stones < 20 mm in kidney or proximal ureter
side effect: renal injury -> may increase BP
CI: pregnancy, AAA, bleeding diathesis
indications for ureteronoscopy + basket removal of kidney stones?
1st line if stone > 10mm in distal ureter or if shock wave lithotripsy failed
or >20 mm in renal pelvis
mx of kidney stones where pt is febrile w renal obstruction?
surgical emergency
percutaneous nephrostomy or ureteric stent
IV abx e.g. cefuroxime
risk factors of renal cell carcinoma?
obesity
smoking
HTN
dialysis
heritable syndrome (e.g. VHL)
most common subtype of renal cell carcinoma?
clear cell
presentation of renal cell carcinoma?
50% incidental finding
triad: haematuria, loin pain, loin mass
systemic: FLAW
clot retention
invasion of L renal vein -> varicocele
cannonball mets -> SOB
paraneoplastic features of renal cell carcinoma?
EPO -> polycythaemia
PTHrP -> high Ca
Renin -> HTN
ACTH -> Cushings syndrome
Amyloidosis
Robson staging for renal cell carcinoma?
(largely replaced by TNM staging)
- confined to kidney
- involves perinephric fat, but not Garota’s fascia
- spread into renal vein
- spread to adjacent/ distant organs
medical mx of renal cell carcinoma?
reserved for pts w poor prognosis
temsirolimus (mTOR inhibitor)
surgical mx of renal cell carcinoma?
radical nephrectomy
consider partial if small tumour or 1 kidney
2nd most common renal cancer?
transitional cell carcinoma
- 50% found in bladder, rest in ureter/ renal pelvis