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Renal II - Midterm > Urogenital Pharm > Flashcards

Urogenital Pharm Flashcards

1
Q

a1 adrenergic antagonists

A

Doxazosin, terazosin, alfuzosin, tamsulosin, silodosin

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2
Q

Steroid 5a-reductase inhibitors

A

Finasteride, Dutasteride

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3
Q

Phosphodiesterase-5 inhibitors

A

Sildenafil, Vardenafil, tadalafil

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4
Q

Role of a1 adrenergic antagonists

A

Drugs that relax muscle tone
Dynamic remedy
Rapid relief of symptoms
-compete with NE to reduce spasm, promote muscle relaxation and improve urine flow

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5
Q

Prostate a1 receptors

A

Smooth muscle contraction

a1A

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6
Q

Detrusor a1 receptors

A

Instability

a1D>a1A

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7
Q

Spinal cord a1 receptors

A

Control of urinary function

a1D

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8
Q

Blood vessels a1 receptors

A

Vascular resistance

a1B>a1A

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9
Q

Sub-type specific a1-antagonists

A

Tamsulosin and silodosin a1A=a1D>a1B

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10
Q

Side effect of Terazocin and Doxazosin

A

Orthostatic hypotension

-Must titrate the first dose

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11
Q

Alfuzosin adverse effect

A

QT prolongation

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12
Q

Tamsulosin and silodosin adverse effect

A

Intraoperative floppy iris syndrome

-Reduced ejaculation

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13
Q

SARI MOD

A
  • Prevents enlargement and shrinks prostate
  • Structural remedy
  • Delayed action: shrinkage takes 3-6 months
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14
Q

What receptor is over expressed in a hypertrophic prostate?

A

SAR II

  • Inhibit this because it is prostate specific
  • Can’t dimerize and go to the nucleus to increase transcription
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15
Q

Dutasteride

A

Dual inhibitor SAR1 and 2

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16
Q

Finasteride

A

Specific inhibitor

SARII

17
Q

What is the only PDE-5 inhibitor approved by FDA to treat BPH?

A

Tadalafil

18
Q

How does NO cause as erection?

A

Combines with guanlyate cyclase to activate cGMP that relaxes smooth muscle

19
Q

What is PDE5 role in an erection?

A

cGMP gets reversed by PDE-5 to end the erection by removing the vasodilation
-Thus the antagonists keep cGMP at higher levels

20
Q

What is the main contraindication to PDE-5 inhibitors?

A

Organic nitrates combined with PDE-5 inhibitors produce extreme hypotension
-Organic nitrates are regularly used in coronary artery disease and with angina pectoris (they release NO)

Renal II - Midterm (13 decks)

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