Urinary Tract Symptoms and Infections Flashcards

1
Q

Define Urinary Tract Infection

A

Infection that occurs in any part of the urinary system and is common caused by bacteria entering the urinary tract and multiplying in the urine, invading the mucosal lining

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2
Q

What are common symptoms of a UTI?

A

Dysuria, nocturia, increased frequency, cloudy urine

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3
Q

What does pyuria indicate?

A

Inflammation or infection in the urinary tracts

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4
Q

What family of bacteria are the most common cause of UTIs and give 2 examples?

A

Enterobacteriaceae: E. Coli and Klebsiella

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5
Q

Define cystitis

A

inflammation of the bladder often caused by bacterial infection

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6
Q

What are the symptoms of cystitis?

A

Increased urgency or frequency of urination, dysuria, cloudy or bloody in the urine

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7
Q

The presence of what 2 substances in the urine from a urine dipstick test indicate a UTI?

A

Nitrites and leukocytes

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8
Q

Does the absence of nitrites on a urine dipstick test rule out the possibility of a UTI?

A

No, nitrites are present in the urine in UTIs caused by Enterobacteriaceae but UTIs can be caused by other bacteria

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9
Q

Define dysuria

A

Painful urination

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10
Q

What is sterile pyuria and what does it indicate?

A

Sterile pyuria is the presence of WBCs in the urine in the absence of bacteria.

Common to see sterile pyuria up to 6 weeks after successful UTI treatment.

Can indicate inflammation or infection in the urinary tract even if urine cultures don’t reveal bacteria growth, may require further investigation

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11
Q

Which bacteria is most commonly responsible for UTIs in the community and hospitals?

A

E. coli

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12
Q

What is the main reason not to over-diagnose UTIs?

A

Increased antimicrobial resistance

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13
Q

Why is urine dipstick not useful for diagnosing UTIs in patients over the age of 65?

A

it is not reliable for the age group because of high rates of bacterial colonisation

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14
Q

What 3 symptoms are indicative of UTI in women younger than 65?

A

all of these symptoms must be new
- dysuria
- nocturia
- cloudy urine

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15
Q

What is the primary cause of most UTIs?

A

GI bacteria ascending the urethra

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16
Q

What is the importance of differentiating between upper and lower urinary tract infections?

A

It determines treatment and duration

17
Q

How is a recurrent UTI defined

A

2 or more UTIs in 6 months
>3 UTIs in 12 months

18
Q

How are uncomplicated and complicated UTIs defined?

A

Uncomplicated UTIs are defined as occurring in a healthy individual with normal urinary tracts and the infection has not spread to the kidney or other parts of the body

Complicated UTIs are defined as occurring in an individual with comorbidities, pregnancy, structural abnormalities of the urinary tract, men and often involved systemic symptoms

19
Q

Define pylonephritis

A

A UTI that affects the kidneys and is caused by bacteria ascending from the bladder, can lead to complications is not treated quickly

20
Q

Why are nitrofurantoin and pivmecillinam only used for uncomplicated UTIs?

A

They don’t get absorbed to any significant level into the bloodstream and can act directly on the urothelium

21
Q

Which antibiotic has a higher association with C. diff infection?

A

Cephalaxin

22
Q

What oral antibiotic is the last choice for treating UTIs and why?

A

Ciprofloxacin because it has a broad spectrum of activity and high risk of side effects which include Achilles tendonitis or rupture, aortic aneurysm or QT prolongation

23
Q

What side effects are associated with Ciprofloxacin?

A
  • Achilles tendonitis and rupture
  • Aortic aneurysm
  • QT prolongation
24
Q

Why should trimethoprim not be used to treat UTIs in pregnant women?

A

It inhibits an enzymes involved in the production of folate and can result in decrease folic acid concentrations which are necessary for fetal development