Urinary System Flashcards
What factors are involved in GFR increase?
Afferent arteriole dilation:
- Prostaglandins
- Kinins
- Dopamine (low dose)
- ANP (atrial natriuretic peptide)
- NO (nitric oxide)
Efferent arteriole constriction:
- Angiotensin 2 (low dose)
What factors are involved in GFR decrease?
Afferent arteriole constriction:
- Angiotensin 2 (high dose)
- Noradrenalin or NE (SNS)
- Endothelin
- Adenosine
- Vasopressin (ADH)
- PG blockade
Efferent arteriole dilation:
- Angiotensine 2 blockade
Renal blood flow (RBF)
1200 ml/min (20-25% of CO)
Renal plasma flow (RPF)
600 ml/min
Equals the clearance of PAH (CPAH)
Glomerular filteration rate (GFR)
120 ml/min (20% of RPF)
Equals Cinulin or Ccreatinine
Filtration fraction (FF)
GFR/RPF = 20%
Glomerular capillary hydrostatic pressure
Afferent end: 53 mmHg
Efferent end: 51
Glomerular capillary oncotic prssure
Afferent end: 26
Efferent end: 33
Bowman’s capsule hydrostatic pressure
Afferent end: 12
Efferent end: 12
Bowman’s capsule oncotic pressure
Afferent end: 0
Efferent end: 0
Net ultrafilteration pressure
Afferent end: 15
Efferent end: 6
Effective filtration pressure (average)
13 mmHg
Osmotic pressure in the proximal tubule
300 mOsm
Osmotic pressure of the interstitium in the cortex
300 mOsm
Urine osmolarity (maximal concentration)
1200 mOsm
Urine osmolarity (maximal dilution)
30 mOsm
Osmotic pressure and composition of the interstitium in the inner medulla during maximal concentration
600 NaCl + 600 Urea = 1200 mOsm
[Glucose]
4-5 mM
Transport maximum of tubular glucose (maximum glucose reabsorption)
375 mg/min
Blood pH
7.35-7.45
PCO2
40 (38-42) mmHg
Buffer base (BB)
44-49 mEq/L
Base excess (BE)
+/- 2.5 mEq/L
[HCO3-]
Standard = 24 (22-26) mmol/L
Actual = 24 (22-26) mmol/L
[H+] of blood
40 nM
200 nano moles or 2 µ moles in 5 liters of blood
Intracellular pH
7.2
Urine pH
5-7 (acidic)
Daily production of acids
1 mmol/kg
70 mmol in a 70 kg man
[Hb] in blood
[Hb] in males: 160-170 g/liter
[Hb] in females: 135-145 g/liter
[Hb] in general: 2-2.8 mM or 120-180 g/liter
These are the concentrations of whole hemoglobin (consisting of four monomers).
[Albumin] in blood
35–50 g/L
Total [protein] in blood
60-80 g/L (not sure)