Urinary Antiseptics Flashcards
15.29
1
Q
Nitrofurantoin - Class
A
Urinary antiseptic
2
Q
Nitrofurantoin - MOA
A
Unchanged drug (~40%) is excreted into urine; bacteria in urinary tract reduce drug to highly reactive intermediates that damages DNA; More active at low pH
3
Q
Nitrofurantoin - Active against…
A
Effective against gram-positive enterococci and gram-negative E. colis
4
Q
Bacteria resistant to Nitrofurantoin (4)
A
Urease forming bacteria Proteus
Pseudomonas, Enterobacter and Klebsiella
5
Q
Methenamine - Class
A
Urinary antiseptic
6
Q
Methenamine - MOA
A
Metabolized to toxic formaldehyde spontaneously in low urine pH, but not in plasma at pH 7.4
7
Q
Methenamine - Tx
A
Prophylaxis of chronic UTI
8
Q
What bacteria should not be tx w/Methenamine?
A
Do not use w/ urease forming Proteus –> alkalinizes pH and prevents drug activation
