uric acid Flashcards
1
Q
uric acid method
interference by reducing substances
A
H202 production (enzymatic)
2
Q
increased or decreased concentration
- lesch-nyhan syndrome (hypoxanthine guanine phosphoribosyltransferase deficiency)
- phosphoribosylpyrophosphate synthetase deficiency
- glycogen storage disease type I (G-6-PD)
A
increased concentration
3
Q
increased or decreased concentration
- fructose intolerance (fructose-1-phosphate aldolase deficiency)
- toxemia of pregnancy
- lactic acidosis
A
increased concentration
4
Q
uric acid method
- problems with turbidity
- several common drugs interfere
A
colorimetric
5
Q
- filtered by the glomerulus and secreted by the (?) into the urine, but mostly absorbed in the (?) and reused
- relatively (?) in plasma, and at high concentrations, can be deposited in the (?) and (?), causing painful inflammation, mostly present as (?) in plasma, wherein it is insoluble at around (?)
A
- distal tubules
- proximal tubules
- insoluble
- joints, tissue
- monosodium urate
- ph 7
6
Q
increased or decreased concentration
- chronic reanal disease
- drugs and poisons
- chemotherapy with azathioprine or 6-mercaptopurine
A
increased concentration
7
Q
uric acid method
needs special instrumentation and optical cells
A
UV (enzymatic)
8
Q
increased or decreased concentration
- purine-rich diet
- increased tissue catabolism or starvation
- enzyme deficiencies
A
increased concentration
9
Q
increased or decreased concentration
- gout
- treatment of myeloproliferative disease with cytotoxic drugs
- hemolytic and proliferative processes
A
increased concentration
10
Q
increased or decreased concentration
- liver disease
- defective tubular reabsorption (fanconi syndrome)
- overtreatment with allopurinol
A
decreased concentration
11
Q
- product of catabolism of purines (guanine and adenosine)
A
uric acid
