Urea Cycle Flashcards
What is the start of the urea cycle?
- carbamoyl phosphate –> citruline or
- asp –> arginosuccinate
This is the enzyme that converts alanine + alpha-keto-glutarate –> pyruvate + glutamate.
alanine aminotransferase (ALT)
This is the enzyme that converts aspartate + alpha-keto-glutarate –> oxaloacetate + glutamate.
aspartate aminotransferase (AST)
What regulates the conversion of carbamoyl phosphate –> citruline?
N-acetlyglutamate (arginine)
Name 3 controls of the urea cycle.
- AST/ALT levels
- N-acetylglutamate
- glu dehydrogenase
What transports ornithine into the mitochondria and citrulline out?
the ORNT 1 transporter
Where is carbamoyl phosphate synthetase I found?
in the mitochondria
What is aspartate aminotransferase (AST)?
the enzyme that converts aspartate + alpha-keto-glutarate –> oxaloacetate + glutamate
What is alanine aminotransferase (ALT)?
the enzyme that converts alanine + alpha-keto-glutarate –> pyruvate + glutamate
What converts carbamoyl phosphate –> citruline?
carbamoyl phosphate synthetase I
What are the products of the urea cycle?
- ADP
- AMP
- Pi
- PPi
- fumarate
- urea
Name the 2 sources of N in the urea cycle.
- ammonia
- aspartate
What is consumed when carbamoyl phosphate –> citruline?
2 ATPs
Where does the urea cycle occur?
in both the mitochondria and cytoplasm
What is the purpose of transamination?
to feed the urea cycle
