Upper Tract Urothelial Flashcards
What percentage of Lynch Syndrome patients develop UTUC?
10-15%
What non urological malignancies should raise your suspicion for Lynch Syndrome?
BOSCE
Bowel (small) Ovarian Sebacceous Colon Endometrial
What pathogenic gene variant has a known increased risk for UTUC?
MSH2
What gene mutation is associated with high risk upper tract disease?
FGFR3
How many lymph nodes should be removed at time of NU to say there’s been an adequate nodal sampling?
8
Who can get neoadjuvant chemotherapy for UTUC?
high risk patients
How do you manage metastatic UTUC with normal renal function?
Gem/cis or MVAC
How do you manage metastatic UTUC with compromised renal function?
Gem/carbo OR
PDL1 inhibitor or PD 1 inhibitor if PDL-1 positive
How do you manage metastatic UTUC that has failed first line treatment?
Nivolumab, Durvalumab, Avelumab, Erdafitinib
