Upper limb - Arthritis Flashcards
How do you classify arthritis?
Arthritis is a broad term for any joint disease which involves inflammation
Can be categorised:
- Degenerative
- osteoarthritis - Inflammatory
- rheumatoid arthritis
- psoriatic arthritis
- gout
- pseudo gout
- SLE - Infective
- septic arthritis
What is osteoarthritis?
Osteoarthritis is a degenerative condition of ARTICULAR CARTILAGE
It is characterised by destruction of articular hyaline cartilage
This leads to:
- remodelling of periarticular bone as the joint tries to repair itself
- structural alteration of the joint incl osteophytes, sclerosis and subchondral cysts
- decompensation and joint failure as natural repair mechanisms fail to cope
- inflammation and synovitis with symptomatic joint
What is rheumatoid arthritis?
Rheumatoid arthritis is an autoimmune inflammatory condition affecting SYNOVIUM
It is characterised by triad of
- persistent synovitis,
- systemic inflammation
- presence of autoantibodies (RF / ACPA)
Autoimmune reaction occurs in response to antigen
This triggers formation of immune complexes and activation of autoantibodies which leads to an inflammatory response within the synovium
- inflammatory cascade leads to up regulation of TNF alpha /IL-1
- synovium becomes thickendped and inflamed - PANNUS
- synoviocytes invade cartilage and tendons
- cause joint destruction and weakening/attenuation of tendons which can lead to rupture.
What are the diagnostic criteria for rheumatoid arthritis?
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What is the clinical course of RA?
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What are the other non-articular manifestations of RA?
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What are the treatment principles for RA?
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What are the causes for a dropped finger in RA?
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What is Caput-Ulnae syndrome??
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What are the typical radiological findings with RA?
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What are the typical radiological findings of OA?
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What is Eatons classification of radiological findings in 1st CMCJ OA?
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What is Sjögren’s syndrome?
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What is Felty’s syndrome?
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What is Caplans syndrome ?
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