unit4 diabetes/endocrine 12q Flashcards
Type 1-
○ Autoimmine disorder
○ Beta cells of the pancreas are destroyed by antibodies
○ Onset usually <30 y/o
○ Abrupt onset
○ Polydipsia, polyuria, polyphagia, and weight loss
○ Requires insulin
○ Could be viral in etiology
Type 2-
Reduction of cells to respond to insulin (insulin resistance) and decreased
secretion of insulin from beta cella
○ Predisposing facors are obesity, physical inactivity, and genetics
○ Onset usually >50 y/o
○ Could have no symptom or polydipsia, fatigue, blurred vision, vascular and neural
complications
○ Accounts for 90% of diabetic patients
● Gestational- Glucose intolerance during pregnancy
Explain acute and chronic complications of DM
● Microvascular Chronic Problems-
○ Retinopathy- Caused by damage to retinal vessels causing leaking and retinal
hypoxia
○ Neuropathy- Progressive deterioration of nerves; loss in sensation or muscle
weakness
○ Nephropathy- Chronic high BG causes damage to blood vessels in kidneys
causing leaking and hypoxia; kidneys allow filtration of larger particles which
damage the kidneys further
Explain acute and chronic complications of DM
● Microvascular Chronic Problems
Caused by damage to retinal vessels causing leaking and retinal
hypoxia
Retinopathy
Explain acute and chronic complications of DM
● Microvascular Chronic Problems-
Progressive deterioration of nerves; loss in sensation or muscle
weakness
Neuropathy
Explain acute and chronic complications of DM
● Microvascular Chronic Problems-
Chronic high BG causes damage to blood vessels in kidneys
causing leaking and hypoxia; kidneys allow filtration of larger particles which
damage the kidneys further
Nephropathy
Explain acute and chronic complications of DM
● Macrovascular Chronic Problems-
○ CV disease
○ Stroke
○ Peripheral vascular disease
Analyze lab values associated with DM and the significance of abnormal values
● Fasting blood glucose-
70-100
> 100 but <126 indicate impaired fasting glucose
> 126 on at least 2 occasions are diagnostic of diabetes
○ Normal is 70-100
○ Levels >100 but <126 indicate impaired fasting glucose
○ Levels >126 on at least 2 occasions are diagnostic of diabetes
Analyze lab values associated with DM and the significance of abnormal values
● Hemoglobin A1C- tells the average BG over the past 3 months
● Hemoglobin A1C- tells the average BG over the past 3 months
○ 4-6%
○ >6.5% are diagnostic for the diagnosis of DM
○ >8% indicate poor diabetic control
● Hemoglobin A1C- tells the average BG over the past 3 months
○ Normal is 4-6%
○ Levels >6.5% are diagnostic for the diagnosis of DM
○ Levels >8% indicate poor diabetic control
Analyze lab values associated with DM and the significance of abnormal values
● Glucose tolerance test-
<140
>140 or <200 indicate impaired glucose tolerance; levels >200 indicate
provisional diagnosis
● Glucose tolerance test-
○ Normal is <140
○ Levels >140 or <200 indicate impaired glucose tolerance; levels >200 indicate
provisional diagnosis
Examine medical and surgical interventions for patients with DM
● Transplantation of the pancreas- cadaver donor
● Iselet cell transplantation- considered experimental
● Yearly eye exams
● Adaptive devices for administering insulin
● Specialized adaptive equipment for blood glucose monitoring
● Control BP
● Eat a healthy diet and exercise
● Smoking cessation
● Drug therapy for nephropathy
● Wear proper fitting shoes and avoid walking barefoot
● Wear clean socks daily and trim toe nails properly
● Report non-healing breaks in the skin of the feet to HCP
● Gabapentin (Neurotin) is a common medication for management of neuropathic pain
Compare and contrast the four types of insulin therapy
Rapid Acting-
a. Onset-
b. Peak-
c. Duration-
Rapid Acting- Aspart and Lispro
a. Onset- 15 minutes
b. Peak- 1-2 hours
c. Duration- 3-5 hours
Compare and contrast the four types of insulin therapy
Short-Acting (Regular)
a. Onset-
b. Peak-
c. Duration-
Short-Acting (Regular)
a. Onset- 30-60 minutes
b. Peak- 2-3 hours
c. Duration- 6-10 hours
Compare and contrast the four types of insulin therapy
Long-Acting (Glargine)
a. Onset- Gradual
b. Peak- None
c. Duration- Up to 24 hours
Long-Acting (Glargine)
a. Onset-
b. Peak-
c. Duration-
Compare and contrast the four types of insulin therapy
Intermediate Acting
a. Onset-
b. Peak-
c. Duration-
Intermediate Acting
a. Onset- 15-2 hours
b. Peak- 1-12 hours
c. Duration- 12-24 hours