Unit 7: Chapter 03 (Karch 7th Ed) - Toxic Effects of Drugs Flashcards
- A nurse is planning patient teaching about a newly prescribed drug. What is a priority teaching point
included by the nurse to improve compliance and safety?
A) List of pharmacies where the drug can be obtained
B) Measures to alleviate any discomfort associated with adverse effects
C) The cost of the brand name drug compared with the generic form
D) Statistics related to Phase III testing for the prescribed drug
Ans: B
Feedback:
If a patient is aware of certain adverse effects and how to alleviate or decrease the discomfort, he or she
is more likely to continue taking the medication. A list of pharmacies can be useful information but will
not improve safety or compliance. Knowing the cost of the brand name versus the generic form could
also be helpful to the patient. However, a substitution may not be allowable and the cost of a drug does
not improve patient safety. Most patients are not concerned with the statistics related to drug testing
and it would not improve compliance or safety even if the patient was interested in the information.
- A patient presents at the clinic complaining of vaginal itching and a clear discharge. The patient reports
to the nurse that she has been taking an oral antibiotic for 10 days. The nurse is aware that the patient is
experiencing what?
A) An adverse reaction from the antibiotic
B) A drug toxicity effect of the antibiotic
C) An overdose of the drug that is damaging to more than one body system
D) A superinfection caused by the antibiotic, which has destroyed normal flora
Ans: D
Feedback:
Superinfections often occur with antibiotic use because the drug kills normal bacterial flora. This is not
a result of toxic levels of the antibiotic, but rather an effect of the medication that has killed normal
flora, which it is designed to do. Vaginal itching and a clear discharge are not considered adverse
effects of an antibiotic. An overdose of a drug that damages more than one body systems is considered drug poisoning.
- A 42-year-old male patient is brought to the emergency department by ambulance. The patient is in
distress. The nurse suspects an anaphylactic reaction resulting from taking oral penicillin. What
assessment findings are important in making this diagnosis?
A) Blood pressure (BP): 186/100, difficulty breathing
B) Hematocrit (Hct): 32%, decreased urine output
C) Temperature: 102º, swollen joints
D) Profuse sweating, Blood Pressure: 92/58
Ans: A
Feedback:
An anaphylactic reaction is an immune reaction that causes a massive release of histamine, which
results in edema and swelling that can lead to respiratory distress and increased blood pressure. A
decreased hematocrit and decreased urine output suggests a cytotoxic reaction. An increased
temperature and swollen joints could suggest serum sickness. Profuse sweating and decreased blood
pressure may indicate cardiac-related issues.
- A patient with seasonal allergies is taking an antihistamine to relieve itchy, watery eyes, and a runny
nose. When planning teaching for this patient, the nurse would include what teaching point?
A) Advise the patient to limit fluid intake to dry out mucous membranes.
B) Advise the patient to avoid driving or operating machinery.
C) Advise the patient to report strange dreams or nightmares.
D) Advise the patient to decrease dietary fat.
Ans: B
Feedback:
An adverse effect of antihistamines is drowsiness, so that injury to the patient or others can occur if
driving or operating machinery. An increase in fluids would be indicated to help keep nasal membranes
moist. It is common for dreams to occur when taking medication and it is not necessary to report them.
Dietary fat should not interfere with the drug metabolism of antihistamines.
- A nurse is providing teaching to a group of patients who are beginning drug therapy for acquired
immunodeficiency syndrome (AIDS). What should be included in her instructions to the group?
A) Take your medications as directed. Poisoning occurs with overdosage causing damage to more
than one body system.
B) Renal injury results from first-pass effect when the drug is excreted from the system.
C) A blood dyscrasia due to drug therapy can be serious. Call us if your skin looks yellowish or you
experience itching.
D) Most drugs are metabolized in the liver and the first indication of damage is dark red papules,
which should be reported immediately
Ans: A
Feedback:
Poisoning resulting from overdosage can lead to the potential for fatal reactions when more than one
body system is affected. Liver, not kidney, injury can be caused by the first-pass effect and can cause
the skin to have a yellow appearance. Most drugs are metabolized in the liver but liver damage causes
jaundice, manifested as a yellow tinge to the skin and sclera. Dark red papules appearing on limbs are
characteristic of Stevens-Johnson syndrome, a potentially fatal erythema multiforme exudativum,
which should be reported but is not due to liver damage
- The pharmacology instructor is talking to the nursing students about potassium-sparing diuretics and
how they can lead to hyperkalemia, indicated by what assessment finding?
A) Urine output of 1,500 mL/24 hours
B) Blood pressure of 98/60
C) Potassium level of 5.9 mEq/L
D) Calcium level of 11.4 mg/dL
Ans: C
Feedback:
The normal range of serum potassium for an adult is 3.5 to 5.0 mEq/L. A level higher than 5.0 mEq/L
can indicate hyperkalemia. Normal urinary output is between 1,500 and 2,000 cc per day. Urinary
output below 1,000 mL per day would include oliguria and would indicate hyperkalemia. A decrease in
blood pressure and pulse can indicate hypokalemia. Hyperkalemia refers to an elevated potassium level
and not an elevated calcium level.
- An 80-year-old patient presents at the clinic for a follow-up appointment. She is taking a macrolide
antibiotic and is experiencing tinnitus. The nurse is talking with family members about home care for
the patient. What should the nurse include in her instructions regarding home care?
A) Keep the patient in a prone position when in bed.
B) Eliminate salt from the patient’s diet.
C) Provide protective measures to prevent falling or injury.
D) Monitor exposure to sunlight.
Ans: C
Feedback:
Macrolide antibiotics can cause severe auditory nerve damage, which can cause dizziness, ringing in
the ears (tinnitus), and loss of balance and hearing. The patient would be at high risk for injury due to
falls. Usually a person who is dizzy is unable to lie flat and needs to recline with the head elevated. Salt
and sunlight are not a component of this patient’s presenting complaint.
8. Oral antidiabetic drugs can cause alterations in glucose metabolism. Patients who are taking these drugs would need to be observed for what? A) Increased urination B) Deep Kussmaul’s respirations C) Thirst and hot or flushed skin D) Confusion and lack of coordination
Ans: D
Feedback:
Antidiabetic medications decrease blood glucose levels. If levels fall too low, symptoms of
hypoglycemia would include confusion and lack of coordination. Elevated blood glucose levels can
occur when the patient does not take the medications. With inadequate dosage, hyperglycemia can
occur, resulting in increased urination in an attempt to eliminate serum glucose, deep Kussmaul’s
respirations to reduce blood pH by eliminating carbon dioxide, thirst, and hot or flushed skin.
- A patient is taking chloroquine (Aralen) for rheumatoid arthritis. What problem reported by the patient
would the nurse suspect may be an adverse reaction of the medication?
A) I have to urinate all the time.
B) Sometimes I have blurred vision.
C) I have tingling in my arms and legs.
D) Sometimes I feel like I am off balance.
Ans: B
Feedback:
Chloroquine (Aralen) can cause ocular toxicity with blurring of vision, color vision changes, corneal
damage, and blindness. Increased urination, tingling, and numbness are signs of hyperkalemia and
hypokalemia. Loss of balance can be caused by auditory damage due to drug toxicity.
- A 68-year-old patient who must take antihistamines for severe allergies is planning a vacation to
Mexico. The nurse will encourage the patient to do what?
A) Avoid sightseeing during the hottest part of the day.
B) Discontinue the antihistamines if he becomes extremely restless.
C) Decrease the dosage of the drugs if he experiences excessive thirst.
D) Continue taking the antihistamines even if he begins to hallucinate.
Ans: A
Feedback:
Antihistamines can cause anticholinergic effects, which would result in decreased sweating and place
the patient at high risk for heat stroke. Avoiding the hottest part of the day will help prevent
dehydration and heat prostration. Extreme restlessness could indicate Parkinson-like syndrome not
usually associated with antihistamines. Excessive thirst is characteristic of hyperglycemia.
Hallucinations are associated with drugs that affect neurologic functioning. Further, nurses should
never tell patients to decrease or discontinue a drug unless the prescriber has instructed them to do so.
- A 77-year-old man is brought to the clinic by his daughter for a routine follow-up appointment. The
daughter tells the nurse that her father is only taking half the prescribed dosage of several of his
medications. What effect would the nurse explain could result from this behavior?
A) Increased risk of primary actions
B) Dermatologic reaction
C) Superinfection
D) Reduced therapeutic effect
Ans: D
Feedback:
Taking too little of the medication would mean that therapeutic levels are not being reached and the
drugs will be less effective at lower dosages. Primary actions are the result of overdose, which is not
the case in this patient who is taking too little of the drug. Dermatologic reactions are not likely if the
patient is taking too little of the drug unless the drug is treating a dermatologic problem, which is not
indicated by the question. Superinfection would only result if the patient was taking an antibiotic,
which is not indicated by the question.
- A patient with Parkinson’s disease is taking an anticholinergic drug to decrease the tremors and
drooling caused by the disease process. The patient complains that he is having trouble voiding. The
nurse would explain that this is what?
A) A hypersensitive action of the drug
B) A primary action of the drug
C) An allergic action of the drug
D) A secondary action of the drug
Ans: D
Feedback:
Sometimes the drug dosage can be adjusted so that the desired effect is achieved without producing
undesired secondary reactions. But sometimes this is not possible, and the adverse effects are almost
inevitable. In such cases, the patient needs to be informed that these effects may occur and counseled
about ways to cope with the undesired effects. The situation described is not a hypersensitivity reaction
that would indicate an allergic reaction, a primary reaction that would be excessive therapeutic
response, or an allergic reaction to the drug.
- The nurse is assessing a patient new to the clinic. The patient says she is allergic to penicillin. What
would be the nurse’s appropriate next action?
A) Ascertain the exact nature of the patient’s response to the drug.
B) Document the patient is allergic to penicillin.
C) Mark the patient’s chart in red that she has a penicillin allergy.
D) Continue to assess the patient for other allergies.
Ans: A
Feedback:
Ask additional questions of patients who state that they have a drug allergy to ascertain the exact nature
of the response and whether it is a true drug allergy. Patients may confuse secondary actions of the drug
with an allergy. Only after it was determined the action was truly an allergy would the nurse document
the allergy, mark the patient’s chart, and continue to assess for other allergies.
- The pharmacology instructor is discussing the adrenergic drug ephedrine with the nursing students and
lists an adverse reaction of this drug as what?
A) Bronchoconstriction
B) Hyperglycemia
C) Cardiac arrhythmias
D) Severe constipation
Ans: B
Feedback:
Ephedrine (generic), a drug used as a bronchodilator to treat asthma and relieve nasal congestion, can
break down stored glycogen and cause an elevation of blood glucose by its effects on the sympathetic
nervous system. Ephedrine does not cause bronchoconstriction, cardiac arrhythmias, or severe
constipation.
15. The nurse needs to consider teratogenic effects of medications when caring for what population of patients? A) Older adults B) Patients with a history of cancer C) Children D) Young adult women
Ans: D
Feedback:
A teratogen is a drug that can harm the fetus or embryo so the nurse would consider the teratogenic properties of medications when caring for woman of child-bearing age including adolescents and
young adult women. Teratogens have no impact on older adults or children. Carcinogens are chemicals
that cause cancer.