Unit 7 Flashcards

1
Q

Risk Factors associated with Birth Trauma

A
  • Maternal risk factors: age younger than 16 or older than 35, primigravida, prolonged or precipitous labor, preterm or postterm labor, and cephalopelvic disproportion
  • Injury can result from dystocia caused by fetal macrosomia, multifetal gestation, abnormal or difficult presentation, and congenital anomalies.
  • Forceps- or vacuum-assisted birth
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2
Q

Birth Trauma
How can Ultrasonography and Elective C/S help?

A

The use of ultrasonography allows antepartum diagnosis of macrosomia and unusual presentations.
- BPP
Elective cesarean birth may be chosen for selected pregnancies to prevent significant birth injuries (for macrosomia or abnormal presentation)
- Also: gastroschisis

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3
Q

Describe Skull fracture and treatment

A

The newborn’s skull can withstand considerable deformation (molding) during the labor and delivery process because suture lines are not completely fused
A neonate who suffers a skull fracture is also likely to have a cephalhematoma (remember, it does not cross suture lines)
Scan done to verify there is no skull fracture
Treatment: typically heals on its own

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4
Q

Fractured clavicle
Risk Factors
Signs/Symptoms
Treatment

A

Risk Factors
- Shoulder dystocia, forceps/vacuum, macrosomia
Signs and symptoms
- Unilateral Moro Reflex (doesn’t move affected arm), limited movement of the arm, crepitus over the bone
Treatment:
- Gentle handling

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5
Q

Fracture of the humerus or femur
Risk Factor
Treatment

A

Risk Factor
- Difficult birth
Treatment
- Immobilizer (slings, splints, swaddles)

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6
Q

Erb-Duchenne Palsy
What is it?
Risk Factors
Signs and Symptoms
Treatment

A

Result of injury to the upper plexus involving nerves C5 and C6 caused by stretching or pulling the head away from the shoulder during a difficult birth
Associated with a shoulder dystocia, fractured clavicle
S/S: arm hangs limp at side, limited movement, absent Moro (do NOT see crepitus)
Treatment: Range of motion exercises

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7
Q

Facial Palsy
Risk Factors
S/S
Treatment

A

Risk Factors: forceps delivery, prolonged labor
The face on the affected side is flattened and unresponsive to the grimace that accompanies crying or stimulation and the eye remains open on the affected side.
Treatment: Education on how to properly feed! Feeding can be prolonged, with milk flowing out of mouth on the affected side
Prevention of damage to the cornea of the open eye (artificial tears, taping eye closed)

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8
Q

Intracranial hemorrhage
Risk Factors of ICH?
Types include:
Symptoms:
Management

A

Risk Factors: forceps or vacuum-assisted delivery
More common in babies before 30 weeks
Subdural hematoma: blood pooling in the subdural space
- The typical history includes a nulliparous mother, with precipitous birth; a difficult forceps-assisted birth; or a LGA infant
- Can see seizures, coma, unequal pupil sizes, apnea
Subarachnoid hemorrhage
- More common type
- Seen when a premature baby has experienced hypoxia during labor and delivery
- Some babies have no symptoms; others can have seizures or apnea
- Diagnosis: Lumbar puncture shows blood in CSF
Important Assessment: Respiratory and Neuro**
Seizures: Reduce stress in the environment by dimming the lights, keeping things quiet, cluster care

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9
Q

Intraventricular hemorrhage
What is it?
S/S?

A

Bleeding into ventricles of the brain
S/S:
- Moro Reflex is diminished or absent
- Apnea
- Lethargy
- Poor feeding practices in baby
- High pitched cry
- Seizures
Prognosis depends on severity of bleeding

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10
Q

Describe the weight categories:
Low Birth Weight:
Very Low Birth Weight:
Extremely L0w Birth Weight:
SGA:
AGA:
LGA:
IUGR:
Why is weight important to viability?
What is the primary cause of low birth weight?
What is important is these infants right after birth

A
  • Low Birth Weight: < 2500 g
  • Very Low Birth Weight: < 1500 g
  • Extremely L0w Birth Weight: < 1000 g
  • SGA: < 10%
  • AGA: 10-90%
  • LGA: > 90%
  • IUGR: intrauterine growth does not reach the expected potential
    Prematurity is the primary reason for low birth weight
    LBW and prematurity: Second leading cause of death in babies because their organs are immature (infection is the first leading cause)
    Less brown fat, difficulty with stable glucose levels -> issues with viability
    Important after birth: Resuscitation
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11
Q

Assessment of preterm infants
Gestational age assessment
Physical characteristics

A

Gestational age assessment
- New Ballard Score, important to do
Physical characteristics
- Minimal creasing in the hands and feet
- Hypotonia
- Extended posture
- Translucent skin, more red
- Decreased subcutaneous fat
- More vernix caseosa
- More lanugo, patchy
- Pinna of the ear is sometimes folded still; very thin and soft
- Undescended testes in males
- Weak cry
- Diminished or absent reflexes
- Weak suck and swallow reflex (poor feeding ability)

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12
Q

Non-modifiable risk factors for preterm labor and birth

A
  • Previous preterm birth
  • Multiple abortions
  • Race/ethnic group
  • Uterine/Cervical anomalies
  • Multiple gestation
  • Polyhydramnios
  • Oligohydramnios
  • Pregnancy-induced hypertension
  • Placenta previa
  • Short interval between pregnancies
  • Abruptio placenta
  • Premature rupture of membranes
  • Bleeding in first trimester
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13
Q

Treatable/Modifiable Risk factors for preterm labor and birth

A
  • Age <17 or >34
  • Unplanned pregnancy
  • Single
  • Low educational level
  • Poverty, unsafe environment
  • Domestic violence
  • Life stress
  • Number of implanted embryos
  • Low pre-pregnancy weight
  • Obesity
  • Incompetent cervix
  • Infection
  • Substance/alcohol use
  • Late or no prenatal care
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14
Q

Describe Respiratory system in preterm infants
Nursing consideration for respiratory system in preterm infants

A
  • Preterm Infants typically do not experience second period of reactivity; they stay in decreased responsiveness
  • Decreased or no surfactant (needed to keep lungs open)
  • Distress: grunting, retractions, nasal flaring, central cyanosis (late sign)
    Have O2 on board**
    Important for O2 to be warm and humidified for thermoregulation and to prevent drying of mucosal membranes*
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15
Q

Cardiovascular assessment in preterm infants

A

Heart rate and rhythm, skin color, blood pressure (BP), perfusion, pulses, oxygen saturation, and acid–base status
Vasodilation -> bradycardia

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16
Q

What puts preterm infants at risk for temperature instability?
What is the goal of thermoregulation interventions?

A
  • Minimal insulating subcutaneous fat
  • Limited stores of brown fat
  • Inadequate muscle mass activity
  • Poor muscle tone, resulting in more body surface area being exposed to the cooling effects of the environment
  • An immature temperature regulation center in the brain
    The goal of thermoregulation is to create a neutral thermal environment
  • Incubator: 97.4 - 98.4 degrees
  • Pre-warm incubator, linens, diaper, monitor probes, stethoscope
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17
Q

Describe preterm infant risks associated with their Central Nervous System?

A

Very immature
* Birth trauma with damage to immature structures
* Bleeding from fragile capillaries
* Predisposition to hypoglycemia

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18
Q

Maintaining adequate nutrition in a preterm infant
Nursing considerations/assessments

A

Best thing to feed a preterm infant: Breastmilk!!!
- Contains immunoglobulins to help fight infection
- Digest breast milk easier
Babies with weak swallow and suck reflexes
- IV dextrose to treat drop in glucose levels
Once baby can suck and swallow, it can feed from bottle or breast
- MONITOR for respiratory difficulties; make sure baby is able to breathe through nurse
- May need tube feedings before taking bottle/breast
Assessments
- Monitor for aspiration
- Monitor voids and stools
- Make sure GI system is working BEFORE feeding by listening to bowel sounds, measuring abdominal girth
- Tube feedings: look at gastric residual
- Check stools for blood
- WEIGH the baby everyday

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19
Q

Respiratory Distress Syndrome
Risk Factors
What causes RDS?
Symptoms
Treatment

A

Risk Factors
- The earlier the baby is born, the more the baby is at risk
- C/S
- White males
- Infection
- Mom has diabetes
Lack of pulmonary surfactant
- Can lead to atelectasis
Symptoms
- Lethargy, hypotonia, tachypnea
Treatment
- Make sure there is a patent airway
- Provide O2, intubation may be necessary
- Monitor for infection

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20
Q

Necrotizing Enterocolitis
Less common in:
When does it occur?
What is it and what causes it?

A
  • Less common in breastfed babies
  • Occurs about 1 month after birth
  • NEC: acute inflammatory disease of the GI mucosa, commonly complicated by bowel necrosis and perforation
  • Cause 1: Intestinal ischemia
    that occurs as a result of asphyxia/hypoxia or blood flow away from the GI tract
  • Cause 2: Bacterial colonization of the initially sterile GI tract with harmful organisms prior to the establishment of normal intestinal flora
  • Cause 3: Enteral feedings though to provide a substrate for bacterial proliferation OR feedings can increase intestinal oxygen demand during absorption, resulting in tissue hypoxia
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21
Q

Necrotizing Enterocolitis
S/S:
Treatment:

A

S/S
- Abdominal distension
- Respiratory distress
- Unstable temperature
- Lethargy
- Bile stained spit up
- Increased gastric residual in tube feedings
- Bloody stools
Treatment
- Goal = prevent it from going further
- Stop tube feedings (may need to do TPN)
- Antibiotic therapy
- Surgery (bowel resection)
If it has gone far, not a good prognosis

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22
Q

Postmature Infants
More at risk for:
Physical Characteristics:

A

Placental insufficiency leads to…
- Increased risk for RDS (not getting O2 needed from placenta)
- Hypoglycemia (monitor Blood Glucose)
Physical characteristics
- Less Subcutaneous Fat (“muscle wasting” because of the decreased nutrients from placenta)
- “Pruny” hands
- NO vernix caseosa
- Dry, cracked (desquamating), parchment-like skin
- NO lanugo
Firm nails extending beyond the fingertips
Can have meconium staining (golden yellow to green) of skin, nails, and cord

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23
Q

Meconium Aspiration Syndrome
What is it?
Interventions
Assessment
Complications

A

Baby passes meconium in utero
Interventions
- The presence of a team skilled in neonatal resuscitation is required at the birth of any infant with meconium-stained amniotic fluid
- The mouth and nares of the infant are not routinely suctioned on the perineum before the infant’s first breath
- Meconium aspirator for Fetal asphyxia
Assessment
- Typically see low APGAR scores, respiratory distress, RALES and RHONCHI
Complications
- Can lead to pneumonia in baby

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24
Q

Infants of Diabetic Mothers have increased risk of…
Why?

A

Congenital anomalies
- Seen in moms with poorly controlled Type 1 or Type 2 diabetes
- Glucose is teratogenic in the embryonic period
- Cardiac, renal, musculoskeletal anomalies
Macrosomia
- Organs tend to be bigger (insulin = growth factor)
- Cardiomyopathy: usually do not show symptoms
- Hyperbilirubinemia
Hypoglycemia
- Baby’s pancreas produces insulin to combat mom’s high blood sugar
- Once delivered, the baby still produces insulin
- Experiences a period of hypoglycemia
Polycythemia
- Increased number of RBCs circulating
- Bruising from difficult delivery: increased RBCs
- Also play a role with hyperbilirubinemia
Respiratory distress
- Decreased amount of surfactant-> higher risk for RDS
- Monitor temperature, glucose, respiratory

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25
Management of Infants with Diabetic Mothers S/S of hypoglycemia? Interventions?
- Check blood sugar at certain times OR watching for signs/symptoms of hypoglycemia to check blood sugar (depends on hospital policy) - S/S of hypoglycemia: jittery, apnea, mild tremors of hands and feet, unconsolable; tachypnea, hypotonia, decreased activity, and cyanosis - Intervention: Give IV dextrose, glucose water
26
Risk factors for Sepsis in Newborns Maternal Intrapartum Neonatal
Maternal - Low socioeconomic status - Late or no prenatal care - Poor nutrition - Substance abuse - Recently acquired STI - Untreated focal infection (urinary tract, vaginal, or cervical) - Systemic infection - Fever Intrapartum - Premature rupture of membranes - Maternal fever - Chorioamnionitis - Prolonged labor - Preterm labor - Use of fetal scalp electrode Neonatal - Multiple gestation - Male - Birth asphyxia - Meconium aspiration - Congenital anomalies of skin or mucous membranes - Metabolic disorders (e.g., galactosemia) - Low birth weight - Preterm birth - Malnourishment - Formula feeding - Prolonged hospitalization - Mechanical ventilation - Umbilical artery catheterization or use of other vascular catheters
27
Early vs. Late onset of Sepsis Best ways to prevent infection Treatment
Early onset/congenital - Occurs 24-72 hours after birth - Most associated with prematurity, prolonged rupture of membranes, procedures during pregnancy or labor/birth, resuscitation after birth, maternal fever, and GBS colonization or bacteriuria Late onset - 7-30 days after delivery - More common in healthcare associated infections, umbilical stump related Preventing infection - Hand hygiene***, - Cord care - Clean feeding supplies - Do not suction too much in babies with "junky" secretions - No artificial nails Sepsis treatment: antibiotics
28
Symptoms of Sepsis
Respiratory - Apnea - Bradypnea - Grunting - Flaring - Retractions Cardiovascular - Tachycardia - Hypotension CNS - Temp instability - Lethargy - Irritability GI - Feeding intolerance - Vomiting - Diarrhea Integumentary - Pallor Metabolic - Hypoglycemia - Hyperglycemia Hematologic - Thrombocytopenia - Neutropenia
29
Torch Infections include... Symptoms?
T: Toxoplasmosis O: Other (HepB, HIV, GBS) R: Rubella C: Cytomegalovirus (CMV) H: Herpes Simplex Virus (HSV) All have vague flu or mono-like symptoms
30
Education to avoid Toxoplasmosis
If a mom has a cat at home, do not change the litter (cat feces contains toxoplasmosis) *especially in first trimester
31
Hepatitis B in baby Symptoms? Interventions for baby? Breastfeeding?
70-90% transmission rate to fetus (blood) Most + infants are symptom free at birth All babies receive HepB vaccine If mom is HepB+ baby HAS to have vaccine AND HepB immunoglobulin (HBIG) - Within 12 hours after birth Can be diagnosed through cord blood sample These babies CAN breastfeed
32
Syphilis How can it be transmitted to baby? What happens to baby in a mom with untreated syphilis? Interventions for syphilis + mom and baby Symptoms of syphilis in babies
- Babies usually acquire this through placenta/amniotic fluid - If mom has untreated syphilis, the baby is more likely to develop congenital syphilis: 40% babies are stillborn - If we find out mom is positive for syphilis and is less than 4 weeks from delivery, treat baby as if it has congenital syphilis - If Mom was treated for syphilis during pregnancy or if she was treated and baby was delivered greater than 4 weeks after treatment, no treatment for baby is necessary - If less than 4 weeks = baby needs treatment - Symptoms: papules, poor feeding, slight hypothermia, “snuffles” ; some may be asymptomatic
33
HIV Interventions for + mom and baby Symptoms in baby?
Transmission rates 1-2% (low because of antiviral therapy) HIV is a medical reason for a mom to be induced Antiviral therapy is started, and 4-6 hours after, the induction is started Symptoms - If mom is +, assume baby + until proven otherwise - HIV + babies usually do not show symptoms at birth - May start showing signs at 1 year - Thrush is usually the first sign
34
Herpes Simplex Virus Interventions for + Mom/baby Maternal effects Fetal effects Treatment
- If mom has history of HSV, do an assessment and make sure there are no active lesions - If mom has had genital outbreaks within the last 30 days, vaginal delivery can NOT happen - Diagnosis for elective C/S - If 30 days post outbreak: can deliver vaginally Maternal Effects - Spontaneous abortion - LBW - Preterm birth Fetal Effects - 50-60% mortality if exposure to active primary lesions is related to neurological complications - Microcephaly - Seizures - Blindness - Apnea - Coma - Developmental delays Treatment - Mom needs to take medication during pregnancy - Acyclovir is okay to take during pregnancy
35
Group B Streptococcus What is it? What can it cause? Interventions
- Bacterial infection found in the lower GI and urogenital tracts - Leading infectious cause of neonatal sepsis and mortality - Screening cultures at 35-37 weeks (if +, mom needs abx) - Mom is usually asymptomatic - Intrapartum prophylaxis: PCN G and Ampicillin If PCN allergy: Cefazolin - If +, baby needs to deliver 4 hours after antibiotic delivery (can’t control) - Test baby for GBS if antibiotics were not given at least 4 hours before delivery
36
Substance Abuse in babies: Withdrawal is know as: Can lead to...
Drugs causing withdrawal in neonates: - Barbiturates - Alcohol - Opioids - Amphetamines Withdrawal: Known as neonatal abstinence syndrome Can affect respiratory status, Cause IUGR, mental retardation, congenital anomalies and fetal death
37
Alcohol abuse S/S of Fetal alcohol syndrome Signs of alcohol withdrawal
Fetal alcohol syndrome: - Flat face - Thin upper lip - Microcephaly - Developmental delays Development delays -> poor speech Signs of alcohol withdrawal: - Jitteriness - Increased muscle tone - Hyperreflexia - Irritability - Seizures
38
Cocaine abuse What can it lead to in babies?
Prematurity, SGA, difficult to console, sensitive to noise and other stimuli, apnea, irritability, tremors - Higher risk for SIDS Don’t experience typical “withdrawal” - Show neurological symptoms (irritable; hypertonic; tremulous) - Higher risk for SIDS - Hard time modulating sleep-wake statues Decrease stimuli
39
Methadone abuse What can it lead to in babies? Breastfeeding?
Buprenorphine Neonatal abstinence syndrome Seizures Disturbed sleep patterns, increased risk for SIDS Sometimes will allow breastfeeding (not for others)
40
Heroin abuse Leads to what in babies? Withdrawal:
Low birth weight, SGA, Neonatal abstinence syndrome Will see withdrawal in 12-48 hours Seem depressed at first, then they become very hyperactive, jittery, poor feeding, shrill cry No tx of withdrawal can lead to vomiting, diarrhea, dehydration, apnea Do NOT give Narcan to these babies: will immediately put baby in NAS
41
Methamphetamines Leads to what in babies?
SGA, lethargy, poor weight gain, premature Appear lethargic, lasts for a few months Do not really have withdrawal symptoms
42
Tobacco abuse leads to what in babies?
Prematurity, LBW, increased. risk for SIDS and respiratory complications
43
Neonatal Abstinence Syndrome Symptoms
Respiratory: irregular respirations, tachypnea, nasal flaring, retractions, cyanosis Neuro: irritability, tremors, shrill cry, seizures, increased tone and exaggerated Moro, hyperreflexia, hyperactivity GI: abnormal feeding pattern, poor sucking/swallowing, frantic sucking, regurgitation, refusal to feed ***Other: frequent yawning, sneezing, mottling of skin***
44
Nursing Care Substance Abuse
Assessment - If we suspect mom is on a substance, do a urine drug screen - Can also do a urine drug screen on baby Education - Detoxing - Getting help Social support - Social services Comfort Baby - Swaddle baby - Reduce stimuli - Sucking on a pacifier is calming for these babies Pharmacologic treatment - For symptoms - Phenobarbital or diazepam for seizures Drug dependence - Open safe environment for discussion Breastfeeding (controversial) - Methadone baby can breastfeed if well controlled; otherwise, do not breastfeed
45
Characteristics of Physiologic jaundice - Who? - When? - Cause?
60% of healthy term newborns Almost all preterm infants experience this 24 hours AFTER birth Usually occur around day 5 or 6, especially in premature infants Broken down RBCS -> unconjugated bilirubin -> jaundice Result of poor feeding, digestion
46
Pathologic jaundice When? Risk factors?
Underlying condition: causing breakdown of RBCs Within 1st 24 hours** Further investigation: - Serum bilirubin exceeding 15 mg/dl - Visible jaundice > than 10 days of life unless receiving breast milk Risk factors: Maternal infection, maternal diabetes, Rh incompatibility
47
Characteristics of Breastfeeding Jaundice Cause, Prevention
Occurs in first days of life in breastfed newborns Associated with poor feeding practices (baby is not latching on right, mom not feeding for full 15 min, etc) Prevention of early breastfeeding jaundice: - Encourage frequent breastfeeding - Assess baby’s latch - Avoid supplementation - Access maternal lactation counseling
48
Phototherapy Who needs it? What does it do? Nursing Considerations (baby safety)
- Pathologic Jaundice NEEDS phototherapy - Physiologic/BF Jaundice sometimes will need phototherapy, but can go away on their own - Converts unconjugated bilirubin into a water-soluble form that can be excreted - Doesn’t have to be in hospital for this (if mild) High-intensity light - Baby can not have clothes on during treatment (besides diaper) - Cover eyes and genitals (diaper) - Measured every 12 hours - Monitor temp to make sure baby is not overheated - Assess I/O to make sure baby is not getting dehydrated - Turn baby every 2 hours to ensure all areas get light
49
Congenital Anomalies are closely linked to...
Maternal obesity Decreasing weight by 5-10% can be significant in helping this
50
Cardiovascular System Anomalies Dx S/S
Early Dx and Tx - Anomalies can occur in the first trimester - Anatomy scan at 16-20 weeks is important for diagnosis! Signs: - Cyanosis - Mottling of skin when crying - Respiratory distress (give O2)
51
Neural Tube Defects Prevention? Encephalocele: Anencephaly: Hydrocephalus: Microcephaly:
Encephalocele - A herniation of the brain and meninges through a skull defect, usually in the occipital area - Treatment: Surgical repair and shunting to relieve hydrocephalus Anencephaly - Absence of brain tissue (absence of both cerebral hemispheres and of the overlying skull) - Incompatible with life - Babies usually die soon after delivery Hydrocephalus - Excess CSF in the ventricles of the brain due to overproduction Microcephaly - Small head circumference - Can be caused by viral infection (e.g., Zika) *Dx as early as possible in utero*
52
Respiratory System Anomalies Laryngeal Web: Intervention
Incomplete separation of two sides of the larynx Put an ET tube in**
53
Respiratory System Anomalies Choanal atresia Symptoms Intervention
Posterior nares are blocked Cyanosis, pallor, other distress symptoms Can not pass a suction catheter through Secure an oral airway** Lay babies on stomach (prone) to reduce severity of symptoms
54
Respiratory System Anomalies Congenital diaphragmatic hernia: Symptoms/effects Intervention
Defect in the formation of the diaphragm Abdominal organs are displaced into the thoracic cavity Size of defect plays a role in severity of symptoms Respiratory distress Lungs do not develop as they should Babies usually have chronic feeding problems Make sure baby is stabilized upon delivery
55
Inborn errors of metabolism Testing What are they usually? When do symptoms appear Most common one: (effects, treatment)
Varying state screening Test 24 hrs after birth Most are inherited autosomal recessive disorder Usually asymptomatic at birth, but after feedings, symptoms start to appear Phenylketonuria - Most common - Causes CNS damage - Babies will have developmental delays - Treatment: “special milk”
56
Care Management Genetic Diagnosis
Prenatal diagnosis - Amniocentesis (testing amniotic fluid) - Chorionic Villus Sample (testing the placenta) Perinatal care Postnatal diagnosis - Multiple anomalies often refer to a “syndrome” Parental and Family Support - Support groups - Genetic counseling and testing for next pregnancy
57
What is Anticipatory Grief? How can healthcare professionals help with infant loss?
Experienced when told of the impending death of infant Prepares and protects parents who are facing a loss Parents who have an infant with a debilitating disease, but one that may not threaten life of child, also may experience anticipatory grief Health care professionals can help by: - First thing: acknowledge it, be a listener - Involving family in infant’s care - Providing privacy - Answering questions - Preparing family for inevitability of death - Growing emphasis on hospice and palliative care for infants and their families
58
Perinatal loss includes: Usual cycle of grieving: What can be very upsetting for mothers after the death of an infant?
Perinatal loss - Ectopic pregnancy - Intrauterine fetal death (IUFD) - Miscarriage - Stillbirth Death after birth - Prematurity - Congenital anomalies - Genetic defects Cycle - Acute distress: Shock - Intense grief: Emotional, cognitive, behavioral, and physical responses. - Reorganization: Return to their usual level of functioning, although the distress associated with the death remains - Bittersweet grief Producing milk can be extremely upsetting in women experiencing infant loss
59
Reaction of siblings in the event of infant loss depending on the age
Younger children: tend to act out or be clingy School-age: scared of what is going on Teenagers: awkward with discussion
60
Care Management Infant Loss
- Actualize loss - Decision making - Acknowledge and express feelings - Postpartum needs - Family - Memories - Cultural/Spiritual - Postmortem care Do not say “baby is dead”, say “baby has passed away” Name he baby Let parents hold the baby Conversation about an autopsy Some parents want to do organ donation