Unit 6 - Circulatory System Flashcards
What are the components of blood?
55% plasma liquid which contains:
91% water
7% proteins
2% salts, gases, wastes, hormones etc.
45% formed elements (solids):
RBC
WBC
Platelets
What is another name for RBC?
Erythrocytes
Describe RBC structure and shape
No nuclei
Biconcave disks
Lives for 120 days
Contains hemoglobin molecules, carbonic anhydrase, and antigens
Made in red bone marrow
What is the function of RBC?
Transports CO2 and O2 and H+ (acts like a buffer)
How do RBC transport oxygen?
RBC transport oxygen as oxyhemoglobin. The Hb attaches to o2 when it’s cool, high pH, and low pressure at the lungs.
How do RBCs transport CO2?
RBCs transport CO2 as carbaminohemoglobin. Hb drops oxygen and picks up CO2 when it’s warm, lower pH, and high pressure at the cells. Hb has a higher affinity for CO than O2 and becomes HbCO.
How do RBCs transport H+?
RBCs transport H+ as reduced Hb.
What’s another name for white blood cells?
Leukocytes
What is the function of WBCs?
WBCs fight infections by producing antibodies or through phagocytosis (engulfing) of pathogen. Can squeeze out of blood vessels to attack invaders.
Describe the shape and structure of a WBC
Has a nucleus
Larger than RBCs
Fewer in number than RBCs
Made in red bone marrow
What’s another name for platelets?
Thrombocytes
What is the function of platelets?
The recognize micro tears in blood vessels and bind together to form a blood clot. Aid in blood clotting.
Describe platelets
Fragments of cells
No nuclei
Irregular shape
Made in the bone marrow
What is step one of the clot formation process?
An injury occurs, damaging cells. The body responds by sending blood to the site.
What is step two of the clot formation process?
Platelets detect damage and release a chemical that initiates a chain of reactions and changes a blood protein called fibrinogen (soluble) into fibrin (insoluble).
What is step three of the clot formation process?
The fibrin is long and string-like and clumps at the injury site, partially blocking blood from leaking out.
What is step four of the clot formation process?
More blood, platelets, and white blood cells arrive at the site, creating a scab and puss.
What is an antigen that is in all body cells?
An identification glycoprotein on a RBC.
Antigen A and antigen B.
What are the four blood types and what type of antigen do they have?
Antigen A - type A blood
Antigen B - type B blood
Antigens A + B - type AB blood
No antigens - type O blood
What is an antibody?
A protein designed to combat any foreign protein.
What does an antibody do and how is it made?
Binds to foreign proteins with foreign antigens causing agglutination (clumping)
WBCs then destroy agglutinated cells
Antibodies are made by WBCs.
How do we not attack our own blood?
Our blood has antibodies that are opposite to the antigens we have on our RBCs.
What is the Rh factor?
It is an antigen that may be present on the RBC.
What happens if you are Rh-?
It means you don’t have the antigen. You don’t normally have the D antibodies, but can make them if you are exposed to the Rh antigen.
What happens if Rh antigens and Rh antibodies mix?
Agglutination occurs
What happens if you are Rh+?
You have the antigen and don’t have the D antibodies.
Why is the Rh factor important in childbirth?
If an Rh- mom has an Rh+ baby, complications can occur with a second pregnancy. Can cause erythroblastosis (the baby dies/is still born). Can be prevented by an Rh immune globylin injection.
What are the 5 main types of blood vessels?
Arteries
Arterioles
Capillaries
Venules
Veins
What is the function of arteries?
To transport blood away from the heart.
Describe the structure, shape and location of arteries
Thick, elastic walls with no valves
Located usually deep, along bones
Walls can expand, heartbeat pumps blood through the arteries, resulting in high blood pressure which decreases as it gets further from the heart.
What is the function of arterioles?
Controls blood flow to capillaries.
Describe the structure and location of arterioles
Location - leading towards all capillaries
Small in diameter, thin walls, have pre-capillary sphincters that that can open and close and regulate blood pressure.
What is the function of capillaries?
Connects arteries to viens.
Describe the structure and location of capillaries
Very thing walls, low blood pressure and low velocity which allow for exchange of nutrients and wastes working cells.
Location - everywhere; within a few cells of each other.
What is the function of venules?
Drains blood from capillaries and moves blood towards the heart. Takes blood to veins.
Describe the structure and location of venules
Location - often near the surface
Thinner walls than veins
What is the function of veins?
Transports blood towards the heart. Valves prevent blood from flowing backwards, surrounded by skeletal muscle that squeezes blood along.
Describe the structure and location of veins
Inelastic walls, contain one way valves
Location - Often near the surface
Blood pressure and velocity is much lower than arteries
What controls movement at the capillaries?
Movement of nutrients, gases, and wastes in and out of the cell at the capillaries is controlled by varying levels of blood pressure and osmotic pressure.
What type of molecules can and cannot pass through the capillary wall?
Small molecules can pass through, but large cells like RBCs cannot.
Where do small molecules diffuse after diffusing out of the blood vessel?
Across the interstitial fluid and into cells.
What does interstitial fluid mean?
Fluid between cells.
Describe capillary fluid exchange on arteriole side
Net blood pressure (15 mmHg) forces water out of the blood into the extracellular fluid.
Water carries O2 and nutrients which diffuses into body cells
The blood becomes hyperosmotic because most of the water has diffused.
Describe capillary fluid exchange on venule side
Blood is concentrated (little water)
Net osmotic pressure (15mmHg) forces water back into the blood
Water carries with it CO2 and metabolic wastes (urea) from extracellular fluid into the blood
These are carried to kidneys and other organs to be removed.
What is intracellular fluid?
The fluid inside the cells
What does hepatic mean?
Liver
What does renal mean?
Kidney
What does pulmonary mean?
Lungs
What does an artery do?
Arteries move blood away from heart
What does a vein do?
Moves blood towards the heart
What does the aorta do?
Moves blood from heart to rest of body
What do the anterior and posterior vena cava do?
Move blood from body to heart
What does myocardium mean?
Muscle tissue that the heart is made of
What does pericardium mean?
The double membrane sac that surrounds the heart
What does pericardial fluid do?
It is between the myocardium and the pericardium to lubricate the heart to prevent friction.
What do coronary arteries do?
They are found on the outside of the heart and they feed the heart muscles nutrients. They bring oxygen rich blood from the aorta.
What are the 4 chambers of the heart?
Right atrium
Right ventricle
Left atrium
Left ventricle
What does the right side of the heart do?
Pumps deoxygenated blood to the lungs = pulmonary circuit
What does the left side of the heart do?
Pumps oxygenated blood to the body = systemic circuit
What is the atria?
It is the upper receiving chambers of the heart