Unit 4 - Wet AMD treatment Flashcards

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1
Q

What is Lucentis?

A

Humanised antibody fragment that binds to VEGF-A

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2
Q

What is Avastin and how is different to Lucentis?

A
  • Full length monoclonal antiobiody
  • Has 2 antigen binding domains c.f. Lucentis which has 1
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3
Q

What is Eylea?

A

VEGF Trap-eye.

BInds to VEGF and placental growth factor

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4
Q

What is the half-life of avastin?

A

17-21 days, less than Lucentis

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5
Q

What indications are there to treat when treating on a prn basis?

A
  • Drop in vision
  • >5 letters
  • New haem IRF or SRF
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6
Q

When should you consider stopping anti-VEGF according to Royal College?

A

V/A below 15 letters

or

gone down by 30.

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7
Q

What are the 3 main complications of intravitreals?

A
  • Endophthalmitis
  • RPE tears
  • Geographic atrophy
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8
Q

GA advances most quickly with which anti-VEGF drug?

A

Lucentis, quicker than Avastin

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9
Q

At what distance from limbus is the anti-VEGF drug given and why? (phakic and pseudoaphakic)

A

4mm , 3.5 mm. Through pars plana

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10
Q

How far is needle inserted into eye?

A

10mm

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11
Q

If patient is less than CF after injection what should be considered?

A

Paracenthesis to lower IOP

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12
Q

What are the symptoms of endophthalmitis?

A

Extreme ocular pain

Vision down

Severely injected eye

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13
Q

What is Faricimab?

A

Anti VEGF A
Anti Ang - 2

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14
Q

What is Brolucizumab?

A

Beovu
Small single chain antibody fragment designed to inhibit VEGF

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15
Q

What did the FLUID study look at and what were the findings?

A

Affect of SRF and IRF on vision.
SRF upto 200 microns was tolerated in relaxed group
IRF, lower baseline va, delayed response and poor va outcomes

No statistical change in v/a but relaced group had less injections

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16
Q

What are the 2 goals of nAMD treatment?

A

Treat to get macula as dry as possible
Prioritize drying over atrophy prevention