Unit 4 Tophat/Quiz Questions

Question 1

Antibody in ELISA assays may be found

Answer 1

-Bound to a plastic plate
-Bound to another antibody
-Fused to an enzyme

Question 2

Why would you expect that individuals who are ‘AB’ can receive blood cells from any donor?

Answer 2

Their pool of B cells have been modified to remove those that recognize ABO antigens

Question 3

Which of the following terms best identifies the role of Shiga toxin in E. coli pathogenesis?

Answer 3

virulence factor

Question 4

All pathogens have adherence functions. What barrier defense mechanism do these overcome?

Answer 4

clearance mechanisms on surfaces

Question 5

Death due to septicemia is most closely associated with

Answer 5

increased blood vessel permeability

Question 6

Which of the following is not an immune mechanism that directly targets extracellular pathogens?

Answer 6

Cytotoxic T cells

Question 7

What are the sources of mutation that cause antigenic drift?

Answer 7

Mutations introduced during replication

Question 8

What type of toxin could be identified by growth on a blood agar plate?

Answer 8

Alpha toxin

Question 9

Would antibodies be effective defense against Neisseria gonorrhoeae?

Answer 9

Yes, but only the IgA class of antibodies

Question 10

What advantage does HSV gain by suppression of MHC I expression?

Answer 10

Inhibits CD8+ T cell response

Question 11

Which of the following immune mechanisms would not be associated with infection caused by this virus?

Answer 11

Neutrophil recruitment

Question 12

What advantage does a pathogen gain by using a structure that is similar to a host cell structure?

Answer 12

avoids detection by lymphocytes

Question 13

Which of the following immune mechanisms would be most effective against Mycobacterium?

Answer 13

T-helper 1 cells

Question 14

What E. coli virulence factor is directly responsible for symptoms leading to septic shock?

Answer 14

Endotoxin

Question 15

Which of the following is shared by the pathogens that cause measles and tuberculosis?

Answer 15

portal of entry

Question 16

Which of the following is an evasion mechanism used by S. typhi?

Answer 16

Vi capsule

Question 17

Some viruses avoid detection by using a specific mechanism to

Answer 17

inhibit synthesis of interferons

Question 18

Listeria monocytogenes evades killing by

Answer 18

disrupting vesicle membranes.

Question 19

Enterotoxins act on intestinal cells by

Answer 19

activating ion export

Question 20

Protein A helps pathogens evade the immune system by

Answer 20

binding antibody

Question 21

What explains why individuals don’t make antibodies against blood group antigens on their own red blood cells?

Answer 21

Self-reactive lymphocytes don’t develop

Question 22

Which of the following is not involved in pathogen avoidance of host surface defenses?

Answer 22

Superantigen

Question 23

Which of the following is not associated with allergic responses?

Answer 23

Bacterial growth in the blood

Question 24

Which of the following is most closely associated with antigenic variation in viral pathogens?

Answer 24

Error-prone polymerases

Question 25

Bacterial pathogens producing exopolysaccharides evade the innate immune response by

Answer 25

resisting internalization by phagocytes

Question 26

There are often many different strains (versions, serotypes) of a particular pathogen. How does the immune system contribute to this?

Answer 26

Provides selective pressure on the pathogen population

Question 27

Which of the following pathogens is not associated with skin infections?

Answer 27

Influenza virus

Question 28

The skin rash associated with shingles is due to

Answer 28

viral infection of the dermal layer

Question 29

Which of the following is the least likely evasion mechanism that would be used by a viral pathogen?

Answer 29

Blocking lysosome fusion

Question 30

Defects in which of the following would increase the likelihood of viral pneumonia?

Answer 30

Mucociliary escalator

Question 31

Pathogens that suppress nutrient absorption by the host

Answer 31

cause diarrhea

Question 32

A portal of entry for Streptococcus pyogenes is the

Answer 32

upper respiratory tract

Question 33

Which of the following is most closely related to systemic effects associated with pathogen infection?

Answer 33

Superantigens

Question 34

Some pathogen infections can lead to autoimmune conditions. These infections are associated with

Answer 34

molecular mimicry

Question 35

Which of the following pathogens would be most susceptible to a strong T helper-1 response?

Answer 35

Salmonella typhi

Question 36

Which of the following is not associated with E. coli pathogens?

Answer 36

Survival inside vesicles