Unit 4 test Flashcards
What is Gigantism?
Gigantism results from hypersecretion of hGH,
What is Acromegaly?
Acromegaly is when hGH hypersecretion occurs in adulthood; acromegaly is a chronic, disfiguring, life-shortening disease characterized by the overgrowth of bones and soft tissues and cardiac dysfunction
What are the s/s of Gigantism?
Excessive growth of the long bones of the body; develops abruptly and results in an abnormal increase in height.
What are the signs and symptoms of Acromegaly?
Acromegaly symptoms appear gradually causing deformation and coarsening of the facial features and enlargement of the hands, feet, head, and tongue; increased sweating, thick coarse oily skin, chronic sinus congestion; headaches, weakness, joint pain, vision disorders, paresthesia (numbness)
What is the treatment for Acromegaly and Gigantism?
Goals involve lowering hGH levels to normal and stabilizing or removing the underlying tumor and minimizing damage to the pituitary gland; transsphenoidal surgery may be performed, radiation therapy
What is the prevention for hyperpituitarism (Acromegaly/Gigantism)?
None
What is Hypopituitarism?
Endocrine deficiency in which any of the hormones produced by the anterior portion of the pituitary gland are secreted at inefficient levels or are absent.
What are the signs and symptoms of Hypopituitarism?
Develop over a period of time, may be vague and easily overlooked; depends on the age and sex; children-dwarfism; gonadotropin deficiency, fatigue, anorexia, weight gain or loss, loss of skin pigmentation, low tolerance of cold, muscle weakness, stiff joints, poor response to stress
What is the treatment of hypopituitarism?
hormone replacement therapy
What is the prevention for hypopituitarism?
none
What is Diabetes Insipidus?
Occurs when the kidneys are unable to conserve water, decreased vasopressin (also called antidiuretic hormone, ADH) allows filtered water to be excreted
What are signs and symptoms of Diabetes Insipidus?
Polyuria, polydipsia, dehydration-dry skin, weakness, fever, mental confusion, prostration
What is the treatment for Diabetes Insipidus?
Treat the underlying cause if possible; fluid intake, hormone replacement therapy, vasopressin medications
What is the prevention for Diabetes Insipidus?
none
What is a simple goiter?
Enlargement of the thyroid gland; simple goiter: any thyroid enlargement not caused by an infection or neoplasm and doesn’t result from another hypothyroid or hyperthyroid disorder; endemic or colloid goiter: result of insufficient dietary intake of iodine; sporadic/nontoxic goiter: follows ingestion of certain foods
What are the signs and symptoms of a Simple Goiter?
Simple: may appear as a small nodule or can be quite massive presenting a conspicuous swollen mass at the front of the neck just above the sternum
What are the treatments for a Simple Goiter?
Goal is to reduce the size of the goiter. Dietary supplements of iodine or T3 and T4 hormone replacement therapy, avoidance of known giotrogenic foods and drugs (sporadic goiter)
What is the prevention for a Simple Goiter?
Adequate Dietary Intake of Iodine
What is Graves Disease?
Condition caused by the OVERSECRETION OF HORMONES BY THE THYROID GLAND; most common form of hyperthyroidism, occurs more frequently in women than in men.
OVERSECRETION OF T3 AND T4 INFLUENCE THE METABOLISM OF CELLS THROUGHOUT THE BODY.
What are the signs and symptoms of Graves Disease?
Goiter, nervousness, anxiety, loss of sleep, excessive perspiration, heat intolerance, wasting of muscle and decalcification of the skeleton, exophthalmos-protruding eyeballs that give the affected individual a “frightened” appearance. Inflammation of muscles surrounding eyes, appearance of thickened patches of skin usually on the feet or legs giving an “orange skin” texture and uneven pigmentation; thyrotoxicosis- cardiac manifestations-tachycardia, arrhythmias, heart murmurs, cardiomegaly
What are the treatments for Graves Disease?
Depends on the affected individual’s age and severity of the case; ANTITHYROID AGENTS, altering the structure of the thyroid gland, administration of iodide compounds, beta blockers
What is the prognosis of Graves Disease?
Varies. A fatal complication of Graves disease is thyroid storm-severe episode of thyrotoxicosis that may occur if the disease is left untreated
What is hypothyroidism?
Undersecretion of hormones by the thyroid gland. Insufficient quantity of thyroid tissue or loss of functional thyroid tissue
What are the signs and symptoms of hypothyroidism?
Neonates: constipation and feeding problems, may sleep too much and have a hoarse cry, brain and skeleton fail to develop properly without treatment; children: retarded growth, delayed emergence of secondary sexual characteristics, impaired intelligence, one of more of the adult symptoms; adulthood: FATIGUE, CONSTIPATION, INTOLERANCE TO COLD, MUSCLE CRAMPS, EXCESSIVE SLEEPINESS, mental clouding, diminished appetite, WEIGHT GAIN, SKIN may become DRY and HAIR AND NAILS MAY BECOME BRITTLE.
What are the diagnostic procedures of hypothyroidism?
Radioimmunoassay shows depressed levels of T3 and T4. TSH high
What is the treatment of hypothyroidism?
Lifelong Hormone Replacement therapy
What is the prevention of hypothyroidism?
Only hypothyroidism due to dietary iodine deficiency, radiation, or surgical removal of the thyroid and drug-induced forms are preventable
What is Hashimoto Thyroiditis?
Most common cause of hypothyroidism is
Inflammation of the thyroid gland; also known as autoimmune thyroiditis more common in women than men. Autoimmune thyroiditis is due to antibodies to thyroid antigens in the blood; Hashimoto thyroiditis-when inflammation causes lymphocytic infiltration
What are the signs and symptoms of Hashimoto Thyroiditis?
Moderate thyroid enlargement accompanied by pain and tenderness, dysphagia, often subtle symptoms that mimic other disorders; fatigue, excessive sleepiness, depression, cold intolerance, dry skin and hair.
What are the diagnostic procedures for Hashimoto Thyroiditis?
Blood testing will reveal T3, T4 hormone levels low, TSH high.
What is the treatment for Hashimoto Thyroiditis?
Lifelong Hormone Replacement Therapy for hypothyroidism, analgesics, anti-inflammatory drugs.
What is the prevention for Hashimoto Thyroiditis?
None
What is Thyroid Cancer?
4 types: PAPILLARY-80% of cases in ages 30-50, slow growing; FOLLICULAR- 10% of cases in those over 50, more likely to spread to lungs or bones; MEDULLARY- mostly sporadic; ANAPLASTIC-very aggressive usually in those over age 60.
What are the signs and symptoms of Thyroid Cancer?
Increasing hoarseness or voice changes, difficulty swallowing, lump felt in the neck
What are the diagnostic procedures for Thyroid Cancer?
Complete physical examination including palpation of the neck to check for lumps or nodules and lymph node swelling.
Ultrasound, biopsy.
What is the treatment for Thyroid Cancer?
Depends on type and stage of cancer; surgery, radioactive iodine therapy, external radiation.
What is hyperparathyroidism (hypercalcemia)?
Disorder of calcium and phosphorus metabolism caused by EXCESSIVE SECRETION OF PTH by the parathyroid glands.
Primary: adenoma on one of the parathyroid glands
What are the signs/symptoms of hyperparathyroidism?
Gradual onset, WEAK, BRITTLE BONES, JOINT PAIN, KIDNEY STONES, POLYURIA, CNS disturbances- DEPRESSION or FORGETFULNESS, NAUSEA, VOMITING, LOSS OF APPETITE, MUSCLE WEAKNESS/ATROPHY, CHRONIC FATIGUE, cardiac disturbances.
What are the diagnostic procedures for Hyperparathyroidism?
Radioimmunoassay reveals elevated concentrations of serum PTH.
What is the treatment for Hyperparathyroidism?
Varies with etiology. Primary: goal is to reduce the level of circulating calcium. Surgically removing neoplastic glands; secondary: treat underlying cause.
What is the prevention for Hyperparathyroidism?
none
What is Hypoparathyroidism?
The UNDERSECRETION of PTH by the parathyroid glands. Caused by Hereditary disorders, deliberate or inadvertent REMOVAL OF PARATHYROID TISSUE DURING SURGERY.
What are the signs and symptoms of Hypoparathyroidism (hypocalcemia)?
TETANY, PARESTHESIA of the extremities, NEUROMUSCULAR IRRITABILITY, MUSCULAR CRAMPS, ANXIETY, MEMORY PROBLEMS, DEPRESSION; WOMEN- DYSMENORRHEA, BRITTLE FINGERNAILS, HAIR LOSS.
How is Hypoparathyroidism diagnosed?
Radioimmunoassay revealing decreased PTH and serum calcium levels.
What is the treatment for Hypoparathyroidism?
Lifelong vitamin D and calcium supplementation, diet high in calcium.
What is the prevention for hypoparathyroidism?
None
What is Cushing’s Syndrome?
HYPERSECRETION OF THE ADRENAL CORTEX of the adrenal glands RESULTING IN THE EXCESS PRODUCTION OF CORTISOL. Bilateral hyperplasia of the adrenal glands due to ELEVATED SERUM LEVELS OF ACTH; benign or malignant NEOPLASMS OF THE ADRENAL CORTEX. LONGTERM ADMINISTRATION OF CORTICOSTEROIDS.