Unit 4, hippocampus and na, floh

Question 1

what is the major cell type in the dentate gyrus?

Answer 1

granule cells

Question 2

cells in the inner 1/3 of the DG are innervated by the this type of fiber

Answer 2

mossy cells

Question 3

mossy fibers in the Dg connect where?

Answer 3

to pyramidal cells in CA3

Question 4

what is special about the mossy fiber/CA3 connection?

Answer 4

sparse, but potent; 1:14

Question 5

what connections come into the DG outer 1/3?

Answer 5

connections from the entorhinal cortex, perforant path

Question 6

is the dG “in the slice?”

Answer 6

yes! spread is less than 400 um

Question 7

what kind of cell is in the hillus and what nt?

Answer 7

glutamatergic mossy cells

Question 8

where are mc of the hillus connecting?

Answer 8

to granule cells of the DG

Question 9

are hillus cells in the slice?

Answer 9

no, project contra too, via associational commisural fibers

Question 10

what fourthings innervate ca3 cells?

Answer 10

dg, recurrent collaterals in ca3, peprofrant path and interneurons

Question 11

what is the connections of ca3 with ca1 called?

Answer 11

projection via chaffer collaerals

Question 12

what is unique about CA3 septo-temporal spread?

Answer 12

very large! talks to everybody; 7mm!!

Question 13

CA1 has compact information, simlar to area

Answer 13

DG

Question 14

where do the pyramidal cells in ca1 go?

Answer 14

project to subicular cells

Question 15

what is the major projection of the subiculum?

Answer 15

out of the hipp, to the cortex, + interneurons

Question 16

what is the role of interneurons in the hippocampus (DG)?

Answer 16

layer, input specific, GABA, few, but can shunt Glut

Question 17

what are three subcortical inputs to the hippocapus?

Answer 17

amygdala, septum, thalamus

Question 18

what are efferents of the subiculum?

Answer 18

thalamus, amygdala, hypothalams, nA

Question 19

what is the role of the hippocampus:

Answer 19

declarative memory. HM, profound anterograde amnesia, probs in declarative mem. consolidation and temporary storage of

Question 20

two tests that would help determine cognative memory in tact in an amnesiac

Answer 20

stem completion and percepual id

Question 21

two non-declaritive tasks that hm is good at:

Answer 21

drawing looking at a mirror, and weather prediction

Question 22

hm cannot do these declaritive tasks

Answer 22

paired assc, draw from memory, story recall.

Question 23

one problem with the slice prep

Answer 23

most intrhippoampal projections cover a substantial spread

Question 24

what is the main function of mossy cells:

Answer 24

mediate communication between dg cells along the axis

Question 25

do CA1 cells talk to each other?

Answer 25

no!

Question 26

what are the major input stations to the hipp

Answer 26

ca1 and the dg

Question 27

what is the main function of interneurons

Answer 27

synchronized, rhythmic activity

Question 28

what is the major subcortical input and output region

Answer 28

septum

Question 29

what is the main nueron type in the NA/

Answer 29

MSN, gabageric ach or gaba inter

Question 30

in a sentence, what is the function of the na?

Answer 30

sensory motor integration

Question 31

why is the core “more motor?”

Answer 31

because it recieves input form substantia nigra

Question 32

why is shell more limbic?

Answer 32

recieves VTA

Question 33

evidence that na are involved in motivation

Answer 33

cells that change their firing rate when presented with an appetitive or aversive stimuli

Question 34

what is a typical “core’ coding of rewared?

Answer 34

cue, lots of firing, until reward is presented, fire again.

Question 35

how is drug addiction coded in na?

Answer 35

increased da, more firing