Unit 4: function of T lymphocytes Flashcards
have surface molecules called CD8
killer (cytotoxic) T lymphocytes
find and destroy infected/abnormal cells
CD8/ killer (cytotoxic) T lymphocytes
destroy body cells that harbor foreign antigens
CD8/ killer (cytotoxic) T lymphocytes
Usually from a pathogen (virus or fungus), but can be
due to a malignancy (cancer), Transplant cells
CD8/ killer (cytotoxic) T lymphocytes
means the T cells
must touch the target victim.
cell-mediated destruction
form immune synapse
cell mediated destruction
surface molecule is CD4
helper T lymphocytes
improve ability of B lymphocytes to become
plasma cells and enhance ability of cytotoxic
T cells to kill targets
CD4/ Helper T cells
activate and coordinate other immune cells, making them essential for both humoral and cell mediated
- recognize antigen presenting cells like dendritic cells, macrophages, and B cells
CD4/ helper T cells
what do helper T cells do
-activate B cells
-activate CD8
-activate macrophages
-secrete cytokines
secrete lymphokines
CD4/ helpter t lymphocytes
type of cytokine secreted by lymphocytes, especially helper t cells (cd4). they regulate the immune response by activating, attracting, and directing other immune cells
lymphokines
helper t cells use lymphokines to:
-turn on the right immune cell for the job
-direct traffic of immune cells to site of infection
surface molecules CD4 and CD25
regulatory t lymphocytes
Previously called suppressor T lymphocytes
regulatory t lymphocytes
Inhibit response of B lymphocytes and killer T
lymphocytes
regulatory T lymphocytes
People with genetic deficiencies in regulatory T
lymphocyte production may develop
autoimmune
diseases and allergies
Originate in the marrow and migrate to most tissues
(especially where pathogens might enter body)
dendritic cells
Engulf protein antigens, partially digest them, and
display polypeptide fragments on their surface for T
cell to “see”
dendritic cells
Associated with histocompatibility antigens
dendritic cells
your bodies “self” ID tags
-These are proteins found on the surface of your cells that help the immune system distinguish self vs non-self. They’re critical in immunity, organ transplants, and antigen presentation.
histocompatibility antigens
Secrete cytokines to attract T lymphocytes in secondary
lymphoid organs
dendritic cells
Once activated, the T cells divide for form effector T
cells and memory T cells
dendritic cells
the ultimate antigen-presenting scouts of the immune system
-are professional antigen-presenting cells (APCs) that play a critical role in starting the adaptive immune response. Think of them as immune messengers that grab antigens, travel to lymph nodes, and show them to T cells.
dendritic cells
found in epithelial tissues (skin, lungs, gut) where pathogens may enter. after capturing antigen, they migrate to secondary lymphoid organs to interact with T cells
dendritic cells
—promote humoral response of B cells by binding to foreign antigens and MHC-2s
Activated helper Ts
