Unit 4 - Effects of Chronic Diseases on the Lower Limb Flashcards
Diabetes
A metabolic disorder characterized by the inability to manufacture or properly use insulin.
The body’s ability to convert sugars, starches, and other foods into energy is impaired.
Long-term effects of hyperglycemia?
The long-term effects of hyperglycemia are damage to the eyes heart kidneys feet nerves large and small blood vessels FL
DM Type 1
More commonly diagnosed in? Percentage of people diagnosed? Cause? Leading to? Treatment?
children and adolescents
10% of people diagnosed with diabetes have Type 1 diabetes.
Pancreatic beta cell destruction causes the pancreas to stop producing insulin.
Without enough insulin, glucose isn’t metabolized properly, so it builds up in the bloodstream.
diet and exercise. clients are dependent on insulin.
DM Type 2
Commonly diagnosed in?
Cause?
Treatment?
adults
The pancreas does not produce enough insulin
or
the body does not use the insulin effectively (insulin resistant).
diet and exercise. oral medication and/or insulin.
Gestational diabetes
Onset of temporary glucose intolerance in pregnancy.
This puts both mother and baby’s health at risk.
Other causes of diabetes?
GGG DED
genetic defects of pancreatic beta cell function
genetic disorders known to cause diabetes
genetic defects in insulin action
drug-induced (corticosteroid-induced)
endocrine disorders known to cause diabetes
disease of the endocrine pancreas
In 2016, how many Canadians aged 12 and older reported being diagnosed with diabetes?
Percentage? # of people?
7%
Roughly 2.1 million people
Male VS Female percentage? (Diabetes)
Males 7.6%
Females 6.4%
Fat prevalence in 2016? (Diabetes)
Obese 13.2%
Overweight 6.6%
Normal weight 3.6%
The percentage of Canadians aged 12 and older who had been diagnosed with diabetes was lowest amongst?
…speaking in QUINTILES then percentage
households that fell within the highest income quintile
4.9%
Which quintiles were most likely to report being diagnosed with diabetes?
Households among the
lowest and second lowest
income quintiles
Between 2004 and 2008, how many diabetes-mellitus-related deaths were recorded in Canada?
They accounted for ??.?% of all deaths that occurred in the period.
120,050
10.6%
In Manitoba, what is the expected increase in diabetes prevalent cases between 2016 and 2026?
37%
Diabetes complications are associated with?
Premature death.
Diabetes reduces lifespan by 5–15 years.
How many deaths in Canadian adults was attributable to diabetes in 2008-2009?
One of ten
Foot ulceration affects an estimated ??%–??% of Manitobans with diabetes in their lifetime.
15%–25%
In 2011–2012, how many amputations were performed on people reporting a diabetic foot wound?
One-third of amputations in 2011–2012
MB – High Risk populations for type 2 diabetes
A SHIT Loo
Asian
South Asian
Hispanic
Indigenous
The Africans
Low income
overweight
older
Diabetes rates in First Nations in comparison to the general population?
Diabetes rates are 3–5 times higher in First Nations than in the general population
Diabetes rates are 3–5 times higher in First Nations than in the general population.
This situation is compounded by?
Barriers to care for Indigenous people
Metabolic syndrome
a cluster of conditions that occur together, increasing risk of
heart disease
stroke
type 2 diabetes
DM-II
Risk factors associated with metabolic syndrome
Hi, HAVA POD
History of IGT (impaired glucose tolerance)
or
IFG (impaired fasting glucose)*
Hypertension
Abdominal obesity*
Vascular disease*
Acanthosis nigricans*
Polycystic ovary syndrome
Overweight
Dyslipidemia
DM-II
More risk factors
1st-degree relative c diabetes
Older than 40
Smoking
Schizophrenia
GDM (gestational diabetes mellitus)
Hx of GDM
Delivery of a macrosomic infant ( > 4500g/9lb)
Of all the risk factors, what risk factor is most important?
Weight
What %age of diabetes sufferers are classified as overweight?
More than 80%
Screening for Type 2 diabetes in individuals WITHOUT risk factors is recommended beginning at?
age 40
Screening for Type 2 diabetes in individuals WITHOUT risk factors is recommended beginning at age 40.
How often? What test?
Every three years the client should have fasting blood glucose levels tested.
How often should individuals with risk factors should be screened? Beginning when?
Testing for clients at risk involves?
annually or more
beginning earlier than 40
a 75-gram oral glucose tolerance test
Signs and Symptoms of diabetes
PIPP’S TUBE
Polyuria Infections - frequent/recurring Polydipsia Polyphagia Slow to heal - cuts/bruises
Tingling on numbness in hands or feet
Unexplained weight loss/gain
Blurred vision
Extreme fatigue or lack of energy
What is important to note about people who have Type 2 diabetes?
It is important to note that people who have Type 2 diabetes may not display symptoms.
The long term effects of hyperglycemia involve?
As well as?
macrovascular and microvascular changes
neuropathy
Diabetes (Type 1 and 2) can result in serious long-term complications affecting
eyesight (retinopathy)
kidney function (nephropathy)
circulation and sensation in the feet
Because diabetes is a systemic disease affecting many different parts of the body, ideal management requires?
a team approach
Because diabetes is a systemic disease affecting many different parts of the body, ideal management requires a team approach?
As foot care nurses in the community, you may be the person the client turns to for answers.
What is and important first step?
Diabetes education
People with diabetes must become knowledgeable about their condition in order to make?
healthy lifestyles choices
In order to prevent foot damage, precautions must be taken with respect to…
PEGS
proper footwear (both socks and shoes)
exercises
gait modifications
skin care
What is the most effective form of Tx?
Prevention!
The foot care nurse, as an integral part of the team, has documented success in the prevention of ?
Amputations?
The key to amputation prevention in diabetic clients is?
Early recognition and regular foot screening
How often should the physician inspect the person with diabetes feet?
The nurse?
@ least annually
the nurse provides regular foot care and assessment Q.4 – 8.Weeks
What does Hyperglycemia lead to? (3)
Further to impaired WBC function, vascular changes can cause? (2)
Poor circulation leads to? (1)
Increased blood viscosity
Inhibition of WBC performance
A hospitable environment for pathogens to flourish
Ischemia and tissue necrosis
Prevention of proper wound healing
What explains why a simple breach of skin integrity can lead to a complicated foot ulcer, which in turn can lead to amputation?
Hyperglycemia causing/creating:
1) Inhibition of WBC performance
2) A hospitable environment for pathogens to flourish
3) Ischemia – poor circulation prevents proper wound healing
Occlusive lesions in vessels of the lower limbs will cause?
This leads to
claudication – pain caused by too little blood flow
leg pain at rest
night cramps
What may relieve leg pains @ rest?
legs in dependent position (dangling)
In the case of a total occlusion
the pain will not be eased by dependency
What is important for both the foot care nurse and the client to recognize?
that a painful, cool, white limb is an emergency
Acute Limb Ischemia
Occurs when???
6 Ps
Occurs when there is a sudden lack of blood flow to a limb.
Pain – Rest pain that worsens on passive movement of the limb and is most severe in the distal aspects of the ischemic limb.
Pallor – Skin over the ischemic limb initially appears pale and then becomes mottled and purple-blue.
Paralysis – Initial muscle weakness progresses to profound irreversible paralysis
Pulselessness – Absent peripheral pulses distal to the site of occlusion
Paresthesia – An abnormal dermal sensation (e.g., a tingling, pricking, chilling, burning, or numb sensation on the skin) with no apparent physical cause
Poikilothermia – The ischemic limb is typically cold to touch but may be warm in hot environments (i.e., it takes on the ambient temperature).
Claudication
pain caused by too little blood flow
What causes claudication?
Occlusive lesions in vessels of the lower limbs
Neuropathy
damage to the nervous system
Neuropathy refers to damage to the nervous system.
It is a…?
Especially in…?
serious and frequent complication of diabetes
clients who have had diabetes for 10 years or more
It is not uncommon for a diabetic client to present with…?
Clients with diabetic neuropathy are frequently unaware that…?
corn and/or callus formation that is “pain free”
they have the condition(s), and may even deny the evidence
Symptoms of neuropathy include:
NL PUPIES
Newfoundland pupies
numbness
loss of feeling/balance
“pins & needles” / tingling or burning
unable to feel feet when walking
pain that is usually worse at night
inability to detect temperature
edema
structural changes in the foot (specifically Charcot’s Foot / Joint)
Charcot’s Foot/Joint
from the interwebs, not ‘text’ book
Diabetes also damages blood vessels, decreasing the blood flow to the feet. Poor circulation weakens bone, and can cause disintegration of the bones and joints in the foot and ankle. As a result, people with diabetes are at a high risk for breaking bones in the feet.
When a diabetic fractures a bone in the foot, he or she may not realize it because of nerve damage. Continuing to walk on the injured foot results in more severe fractures and joint dislocations. Sharp edges of broken bone within the foot can point downward toward the ground, increasing the risk of chronic foot sores from the abnormal pressure.
The combination of bone disintegration and trauma can warp and deform the shape of the foot. This condition is called Charcot arthropathy, and is one of the most serious foot problems that diabetics face.
Screening with a 10 gram monofilament is a validated method to assess for…
This can help determine…
protective sensation (neuropathy) in the feet
the risk of foot ulceration
Monofilament testing is simple, inexpensive, non-invasive and a useful test that should be used when and for what
At regular intervals – ongoing monitoring
To Ax the sensory perception in the feet
Monofilament testing results should be?
And?
documented for ongoing monitoring
referrals should be made as appropriate
Sensory neuropathy
nerve damage that affects the body’s ability to sense pain
Sensory neuropathy is manifested by?
sensations of burning feet or numbness
Sensory neuropathy is manifested by sensations of burning feet or numbness.
This can lead to? (3)
Injury
Impaired proprioception*, often causing changes in gait pattern
*Proprioception (position sense) the ability to feel whether or not the foot is firmly planted on the ground
Autonomic neuropathy
nerve damage that affects the body’s ability to regulate body temperature
Autonomic neuropathy occurs when the nerves that control involuntary bodily functions are damaged.
Autonomic neuropathy is manifested by?
Which leads to?
What is a common cause of fissures?
decrease in production of sweat, reducing or eliminating perspiration
leading to dry, cracked atrophic skin
anhidrosis - the inability to sweat normally
Dehydration of the epidermis results in?
Impaired skin integrity d/t loss of keratin, flexibility and elasticity
Motor neuropathy
nerve damage that affects the intrinsic muscles ability to receive and send messages to flex and extend the foot
Motor neuropathy is manifested by?
an imbalance with the larger extrinsic muscles
or
dislocation or collapse of the foot
nerve damage that affects the body’s ability to sense pain
Sensory neuropathy
nerve damage that affects the body’s ability to regulate body temperature
Autonomic neuropathy
nerve damage that affects the intrinsic muscles ability to receive and send messages to flex and extend the foot
Motor neuropathy
What are three components to peripheral neuropathy?
Sensory
Autonomic
Motor
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
SENSORY NEUROPATHY
– Pathophysiology
Myelin sheath disrupted by hyperglycemia
Disruption leads to segmental demyelinization process
accompanied by
slowing of motor nerve conduction
and
impairment of sensory perception
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
SENSORY NEUROPATHY
– Assessment
10-gram (5.07) monofilament
to determine the presence of protective sensation
gait analysis
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
SENSORY NEUROPATHY
– Outcome
loss of protective sensation
sensory ataxia
leading to
falls
Rate of falls in person with sensory neuropathy secondary to diabetes?
15-fold increase compared to those without diabetes
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
AUTONOMIC NEUROPATHY
– Pathophysiology
SLAP BG
sympathetic denervation (denervation = loss of nerve supply)
loss of vasomotor control
(vascular bed becomes widely dilated)
arteriovenous shunting (autonomic neuropathy can result in an increased rate of blood flow. the faster rate of blood flow, exacerbated by poor glucose control, results in new channels opening up between the arterial and venous systems in the lower leg and foot. this is called arteriovenous shunting. Shunt = the act of pushing something)
peripheral blood flow
(increased)
bone blood flow hyperemia
(hyperemia = increase in blood flow to a tissue due to a change in general conditions. increased blood flow causes bone resorption and weakening.)
glycosylation of collagen
arteriovenous shunting
Autonomic neuropathy can result in an increased rate of blood flow. The faster rate of blood flow, exacerbated by poor glucose control, results in new channels opening up between the arterial and venous systems in the lower leg and foot. This is called arteriovenous shunting.
This phenomenon is thought to be aggravated by the rigidity of the smaller arteries in the foot caused by arteriosclerosis and the widely dilated vascular bed caused by autonomic disorder.
Clinically these changes are seen as the presence of distended veins over the dorsum of the foot and lower leg, and an easily palpable, bounding pulse in the foot. Although these signs could be interpreted as indicators of a good blood supply to the foot, it has been suggested that the fast rate of flow actually fails to fill the smaller vessels of the foot resulting in a reduced distal blood supply. Although the foot is warm to the touch with a strong pulse, the autonomic pathology and co-existence of micro and macrovascular disease means the picture of healthy skin and a good pulse is often confused by the presence of localised ischaemia or ulceration.
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
AUTONOMIC NEUROPATHY
– Assessment
I’M LTD
inspect between the toes especially between the fourth and fifth toes for fissures
maceration
loss of hair growth
thickened toenails
dry scaly skin caused by lack of hydration
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
AUTONOMIC NEUROPATHY
– Outcomes
FAP COW
fissures
anhydrosis
peripheral edema
callus
onychomycosis (fungal nails)
waxy skin = altered joint mobility
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
MOTOR NEUROPATHY
– Pathophysiology
Subluxation of metatarsophalangeal joints
(a subluxation is a partial dislocation, where the bones are out of position, but not completely separated).
Atrophy of intrinsic muscles of the foot
(toe plantar flexors)
Non-enzymatic glycosylation
(non-enzymatic glycosylation is the covalent attachment of a sugar to a protein or lipid. Glycosylation refers to the covalent bonding of blood glucose to the red blood cells. Normally, only a small percentage of blood glucose, usually between 4.5%- 6%, is covalently linked to the red blood cells in hemoglobin of the non diabetes population.)
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
MOTOR NEUROPATHY
– Assessment
RAID
range of motion
absent deep tendon reflexes
increased peak pressure
diminished vibratory sense
COMPONENTS of peripheral neuropathy
& how they may increase risk of ulcer development
MOTOR NEUROPATHY
– Outcomes
Cchamp pa
Charcot arthropathy
claw toes
Hyperextension of the MTP, a flexion deformity at both the proximal interphalangeal joint (PIP) and the distal interphalangeal joint (DIP)
With claw toe, the joint at the base of the toe is bend up. The middle joint is bent down.
hammer toes
Flexion deformity of the proximal interphalangeal joint (PIP) along with a hyperextension of the distal interphalangeal joint (DIP). The MTP joint is neutral or extended.
With hammertoe, the middle joint is bent
ankle equinus
Equinus is a condition in which the upward bending motion of the ankle joint is limited. Someone with equinus lacks the flexibility to bring the top of the foot toward the front of the leg.
muscle weakness
Pes Cavus (high arch) An increase in the height of the medial longitudinal arch. The subtalar joint (Articulation b/w the talus and calcaneus) is hyperflexed. There is an alteration in the position of the talus and the navicular.
Pes Planus (flat foot) Flattening of the medial longitudinal arch usually involving the talus, navicular and associated tendons and ligaments achilles tendon contracture