Unit 3: Pt. 2 Flashcards
How does the spinal cord and spinal nerves contribute to the homeostasis?
By providing quick, reflexive responsiveness to many stimuli.
What are two layers of protection for our central nervous system?
- Vertebral column
- The meninges
What is the space between the the meningeal membranes?
The cerebrospinal fluid.
Explain what the vertebral column do for protection.
The spinal cord is located within the vertebral canal of the vertebral column. The surrounding vertebrae provides a sturdy shelter for the enclosed spinal cord.
Explain what the meninges do and what are the three types?
They are three protective, connective tissue coverings that encircle the spinal cord and brain. The spinal meninges surround the spinal cord and are continuous with the cranial meninges, which encircles the brain.
- Dura mater
- Arachnoid mater
- Pia mater
Explain what the epidural space is and what does it contain.
The spinal cord is also protected by a cushion of fat and connective tissue located in the epidural space, a space between the dura mater and the wall of the vertebral column.
Explain what the Dura mater is.
The most superficial layer the three layers. It is a thick strong layer of dense irregular connective tissue. The dura mater forms a sac from the level of the foramina magnum in the occipital bone, where it is continuous with the meningeal dura matter of the brain, to the sacral second vertebrae. The dura mater is also continuous with the epinerium, the outer covering of spinal and cranial nerves.
Explain what the Arachnoid mater is.
The middle layer of the meningeal membranes. It is a thin, avascular covering comprised of cells and thin, loosely arranged collagen and elastic fibers. It is deep to the Dura mater and is continuous through the foramen magnum with the Arachnoid mater is a thin subdural space, which contains the interstitial fluid.
Explain what the Pia mater is.
The inner most meninges layer. It is a thin transparent connective tissue layer that adheres to the surface of the spinal cord and brain. it consists of thin squamous to cuboidal cells within interlocking bundles of collagen fibers and some fine elastic fibers. Within the Pia mater are many blood vessels that supply oxygen and nutrients to the spinal cord.
Explain what the denticulate ligaments.
Triangular shaped membranous extensions of the Pia Mater suspend the spinal cord in the middle of its dural sheath. These extensions, called denticulate ligaments, are thickenings of the Pia mater. The ligaments protect the spinal cord against sudden displacement that could result in shock.
Explain what the subarachnoid space is.
Located between the Arachnoid mater and Pia mater is a space called subarachnoid space, which contains shock absorbing cerebrospinal fluid.
Explain what the spinal cord is.
The spinal cord is roughly oval in shape, being flattened slightly anteriorly and posteriorly. During early childhood, both the spinal cord and the vertebral column grow longer as part of the overall body growth.
Explain the difference between the cervical enlargement and the lumbar enlargement.
The cervical enlargement contains nerves that control the upper limbs.
The lumbar enlargement contains nerves that control the lower limbs.
Explain what the conus medullaris is.
Inferior to the lumbar enlargement, the spinal cord terminates as a tapering, conical structure called the conus medullaris, which ends at the level of the intervertebral disc between the first and second lumbar vertebrae in adults.
Explain what the filum terminate is.
Arising form the conus medullaris is the filum terminate, which is an extension of the Pia mater that extends inferiorly. It fuses with the arachnoid mater, and dura mater and anchors the spinal cord to the coccyx.
Explain what the spinal nerves are.
Spinal nerves are the paths of communication between the spinal cord and specific regions of the body.
How many spinal nerves are there and where are they lcoated?
There are 31 pairs of spinal nerves.
- 8 pairs of cervical nerves
- 12 pairs of thoracic nerves
- 5 pairs of sacral nerves
- 1 pair of coccygeal nerve
Explain what roots are and the two types.
Two bundles of axons, called roots, connect each spinal nerve to a segment of the cord by even smaller bundles of axons called rootlets.
The posterior (dorsal) root and rootlets contain only sensory axons, which conduct nerve impulses from sensory receptor in the skin, muscles, and internal organs into the CNS.
The anterior (central) root and rootlets contains axons of motor neurons, which conduct nerve impulses form the CNS to effectors.
What are the two main component of the internal part of the spinal cord?
White and grey matter.
Differentiate between white matter and grey matter.
The white matter consists primarily of bundles of myelinated axons of neurons.
The grey matter contains unmyelinated neurons.
Differentiate between the anterior median fissure and posterior median suculus.
The anterior median fissure is a wide groove on the anterior (ventral) side.
The posterior median suculus is a narrow furrow on the posterior (dorsal) side.
Explain what the grey commissure is. And where the central canal is.
The grey commissure forms the crossbar of the H. In the centre of the grey commissure is a small space called the central canal which is filled with cerebrospinal fluid.
Explain what a nuclei is. Differentiate between sensory nuclei and motor nuclei.
In the grey matter of the spinal cord and brain, clusters of neuronal body form functional groups called nuclei.
Sensory nuclei receive input from receptors via sensory neurons, and motor nuclei provide output to effector tissue via motor neuron.
Explain what horns are. Differentiate between the posterior grey horns and anterior grey horns.
The grey matter on each side of the spinal cord is subdivided into regions called horns.
The posterior (dorsal) grey horns contains axons of incoming sensory neurons as well as cell bodies and axons of interneurons.
the anterior (ventral) grey horns contains somatic motor nuclei, which are clusters of cell bodies of somatic motor neurons that provide nerve impulses for contracting of skeletal muscle.
Explain what the lateral grey horns are and what is unique about them?
Between the posterior and anterior grey horns are the lateral grey horns, which are present only in the thoracic and upper lumbar segments of the spinal cord.
The lateral grey horns contain autonomic motor nuclei, which are clusters of cell bodies of autonomic motor neurons that regulate the activity of cardiac muscle, smooth muscle and glands.
Explain what tracts are. Differentiate between sensory (ascending) tracts and motor (descending) tracts.
Columns on the white matter contains distinct bundles of axons. These bundles, which may extend long distances up or down the spinal cord, are called tracts, which are bundles of axons in the CNS, nerve are bundles of axons in the PNS.
Sensory (ascending) tracts consists of axons that conduct nerve impulses toward the brain.
Tracts consisting of axons that carry nerve impulses from the brain are called motor (descending) tracts.
The following is how the spinal cord allows sensory input and motor output to be processed:
- Sensory receptors detects a sensory stimuli
- Sensory neurons convey this sensory input in the forms
of nerve impulses along their axons, which extends from
sensory receptors into the spinal nerve and into the
posterior root. From the posterior root, axons of sensory
neurons may proceed along three possible paths. - Axons of sensory neurons may extend into the white
matter of the spinal cord and ascending to the brain as
part of the sensory tract. - Axons of sensory neurons may enter the posterior grey
horn and synapse with interneurons whose axons extend
into the white matter of the spinal cord and then ascend
to the brain as part of a sensory tract. - Axons of sensory neurons may enter the posterior grey
horn and synapse with interneuron that in turn synapse
with somatic motor neurons that are involved in spinal
reflex pathways. - Motor output from the spinal cord to skeletal muscles
involves somatic motor neurons of the anterior grey
horn many somatic motor neuron are regulated by the
brain. Axons from higher brain centre form motor tract
that descend from the brain into the white matter of the
spinal cord. There they synapse with somatic motor
neurons either directly or indirectly by first synapsing
with interneurons that in turn synapse with somatic
motor neurons. - When activated, somatic motor neurons convey motor
output in the form of nerve impulses along their axons,
which sequentially pass through the anterior grey horn
and anterior root to enter the spinal nerve. From the
spinal nerve, axons somatic motor neurons extend to
skeletal muscles of the body. - Motor output from the spinal cord to cardiac muscle,
smooth muscle, and gland involves autonomic motor
neurons of the lateral grey horn. when activated,
autonomic motor neurons convey motor output in the
form of nerve impulses along their axons, which
sequentially pass through the lateral grey horn, anterior
grey horn , and anterior root to enter the spinal nerve. - From the spinal nerve, axons of autonomic motor
neurons from the spinal cord synapse with another
group of autonomic motor neuron located in the PNS.
The axons of this second group of autonomic motor
neurons in turn synapse with cardiac muscle, smooth
muscle, and glands.
How much white matter are then in the spinal cord?
The amount of white matter decreases from cervical to sacral segment of the spinal cord.
What are the two major reasons for the decrease of the shite matter in the spinal cord?
- As the spinal cord ascends from sacral to cervical
segments, more ascending axons are added to spinal
cord white matter to form more sensory tract. - As the spinal cord descends from cervical to sacral
segments, the motor tracts decrease in thickness as
more descending axons leave the motor tracts to
synapse with neurons in the grey matter of the spinal
cord.
Explain what spinal nerves are.
Spinal nerves are associated with the spinal cord and, like all nerves of the PNS, are parallel bundles of axons and their associated neuroglia cells wrapped in several layers of connective tissue.
What does the spinal nerve connect to?
Spinal nerves connect the CNS to sensory receptors, muscles, and glands in all parts of the body.
Does the spinal cord segment align with the corresponding vertebrae?
Not all spinal cord segments are aligned with their corresponding vertebrae.
Where does the pairs of the spinal cord emerge out of?
The first cervical pair of spinal nerves emerges form the spinal cord between the occipital bone and the atlas. Most of the remaining spinal nerves emerge from the spinal cord through the intervertebral foramina between the adjoining vertebrae.
What does mixed nerve mean?
Because the posterior root contains sensory axons and the anterior root contains motor axons, a spinal nerve is classified as a mixed nerve.
What are the three coverings of spinal nerves?
- Endoneurium
- Perineurium
- Epineurium
Explain where and what the endoneurium is.
The inner most layer of the spinal nerve coverings. It consists of a mesh of collagen fibers, fibroblasts, and macrophages. Groups of axons with their endoneurium are held together in bundles called fascicles.
Explain the middle layer of the spinal nerves.
The perineurium is the middle layer. It is a thicker layer of connective tissue.
What is the outermost layer of the spinal nerve coverings?
The outermost covering over the entire spinal nerve is the epineurium. It consists of fibroblast and thick collagen fibers.
Explain what branches and ramis are.
A short distance after passing through its intervertebral foramen, a spinal nerve divides into several branches. These branches are known as rami.
Explain what the posterior (dorsal) ramus is.
The posterior (dorsal) ramus serves the deep muscle and skin of the posterior and anterior rami.
Explain what the meningeal branch is.
The spinal nerves also give off a meningeal branch. This branch reenters the vertebral cavity through the intervertebral foramen and supplies the vertebrae, vertebral ligaments, blood vessels and the meninges.
What are plexus?
Axons from the anterior rami of spinal nerves, except for thoracic nerves T2-T12, do not go directly for the body structures they supply. Instead, they form networks on both of the left and right sides of the body by joining with various numbers of axons from anterior rami of adjacent nerves. Such a network of axons is called a plexus.
What are the five named plexus’?
- Cervical plexus
- Brachial plexus
- Lumbar plexus
- Sacral plexus
- Coccycgeal plexus (smaller)
Explain what the intercostal nerves are.
The anterior rami of spinal nerves T2-T12 do not enter into the formation of plexuses and are known as intercostal nerves or thoracic nerves. These nerves directly connect to the structures they supply in the intercostal spaces.
Explain the three main intercostal nerves.
- T2: Supplies the skin of the axilla and posterio-medial
aspects of the arm - T3-T6: Extend along the costal grooves of the ribs and
then to the intercostal muscles and skin of the anterior
and lateral chest wall. - T7-T12: Supply the intercostal muscles and abdominal
muscles, along with the overlying skin.
What does the posterior ramis of the intercostal nerves supply?
The posterior rami of the intercostal nerves supply the deep back muscles and skin of the posterior aspects of the thorax.
Explain what dermatomes are.
The skin over the entire body is supplied by somatic neurons that carry nerves impulses from the skin into the spinal cord and brain. One of the cranial nerves, the trigeminal (V) nerves, serves most of the face and scalp. The area of the skin that provides sensory input to the CNS via one pair of spinal nerves or the trigeminal nerve is called a dermatome.
Why is it important to know which spinal cord segments supply which?
Knowing which spinal segments supply each dermatome makes it possible to locate damaged regions of the spinal cord. If the skin in a particular region is stimulated but the sensation is not perceived, the nerves supplying that dermatome are probably damaged.
Why is it important to apply anesthetic drug to adjacent spinal nerves?
Because dermatomes overlap, deliberate production of a region of complete anesthesia may require that at least adjacent spinal nerves be cut or blocked by an anesthetic drug.
Explain what the cervical plexus is.
It is formed by the rots of the first four cervical nerves, with contributions from the 5th cervical nerve. There is one on each side of the neck alongside the first cervical vertebrae. the cervical plexus supplies the skin and muscles of the head, neck, and superior part of the shoulder and chest.
Explain what the brachial plexus is.
The roots of spinal nerves C5-C8 and T1 form the brachial plexus, which extends inferiorly and laterally on either side of the last four cervical and first thoracic vertebrae. It passes above the first rib posterior to the clavicle and then enters the axilla.
The brachial plexus provides almost the entire nerve supply of the shoulders and upper limbs.
Explain what the lumbar plexus is.
The roots of spinal of L1-L4 form the lumbar plexus. Unlike the brachial plexus, there is minimal intermingling of fibers in the lumbar plexus. The lumbar plexus supplies the anterolateral abdominal wall, external genitals, and part of the lower limbs.
Explain what the sacral and coccygeal plexus are.
The roots of spinal nerves L4-L5 form the sacral plexus. this plexus is situated largely anterior to the sacrum. The sacral plexus supplies the buttocks, perineum, and lower limbs. The largest nerve in the body, the sciatic nerve, arises from the sacral plexus.
What are the two principal functions of the spinal cord to maintain homeostasis?
- Nerve impulse propagation
- Integration of information
What are the white and grey matter tracts jobs?
The white matter tracts in the spinal cord are highways for nerve impulse propagation. Sensory input travels along these tracts towards the brain, and motor output travels from the brain along these tracts towards skeletal muscle and other effector tissues.
They grey matter of the spinal cord receives and integrates incoming and outgoing information.
The following are the functions of the spinal cord and the spinal nerves:
- The white matter of the spinal cord contains sensory and
motor tracts, the ‘highways’ for conduction of sensory
nerve impulses toward the brain and motor nerve
impulses from the brain toward effector tissues. - The spinal cord grey matter is a site for integration
(summing) of excitatory postsynaptic potentials (ESPS)
and inhibitory postsynaptic potentials (IPSP). - Spinal nerves and the nerves that branch from them
connect the CNS to the sensory receptors, muscles, and
glands.
What are the two main routes the nerve impulse propagates up the spinal cord to the brain?
- The spinothalamic tract
- The posterior column
Explain what the spinothalamic tract is.
The spinothalamic tract conveys nerve impulses for sensing pain, temperature, itch, and tickle.
Explain what the posterior column is.
The posterior column consists of two tracts:
- The gracile fasciculus
- The cuneate fasciculus
The posterior column tracts conveys nerve impulses for touch, pressure, vibration, and conscious proprioceptions.
What is the sensory information integrated by?
The sensory system keeps the CNS informed of changes in the external and internal environment. The sensory information is integrated (processed) by interneurons in the spinal cord and brain.
How do motor output travel down the spinal cord?
Motor output to skeletal muscles travel down the spinal cord in two types of descending pathways: Direct and indirect.
Differentiate between direct motor pathways and indirect motor pathways.
The direct motor pathways, also called pyramidal pathways, include the lateral corticospinal, anterior corticospinal, and corticobular tract. They convey nerve impulses that originates in the cerebral cortex and are destined to cause voluntary movements of skeletal muscles.
Indirect motor pathways, also called extramyramidal pathways, include the rubrospinal, tectospinal, vestibulospinals, lateral reticulospinal, and medial reticulospinal tracts. These tracts conveys nerve impulses form the brainstem to cause automatic movements and help coordinate body movements with visual stimuli.
Define what reflex is.
A second way the spinal cord promotes homeostasis is by serving as an integrating centre for some reflexes. A reflex is a fast, involuntary, unplanned sequence of actions that occurs in response to a particular stimuli.
Differentiate between:
- Spinal reflex
- Cranial reflex
- Somatic reflex
- Autonomic reflec
- When integration takes place in the spinal cord grey
matter, the reflex is a spinal reflex. - It integration occurs in the brainstem rather than the
spinal cord, the reflex is called a cranial reflex. - Somatic reflex involves contraction of skeletal muscles.
- Autonomic (visceral) reflexes generally are not
consciously perceived. They involve responses of smooth
muscle, cardiac muscle, and glands.
Define what a reflex arc is.
The pathway followed by nerve impulses that produce a reflex is a reflex arc (reflex circuit).
What are the five functional components of a reflex arc?
- Sensory receptor
- Sensory neuron
- Integrating centres
- Motor neuron
- Effector
Define what the sensory receptor is in relation to the reflex arc.
The distal end of the sensory neuron or an associated sensory structure serves as a sensory receptors. It responds to a specific stimulus – A change in the internal or external environment – by producing a graded potential called a generator (or receptor) potential. If a generator potentials reaches the threshold level of depolarization, it will trigger one or more nerve impulses in the sensory neuron.
Define what the sensory neuron is in relation to the reflex arc.
The nerve impulses propagate from the sensory receptor along the axon of the sensory neuron to the axon terminals, which are located in the grey matter of the spinal cord or brainstem. From here, relay neurons send nerve impulses to the area of the brain that allows conscious awareness that the reflex has occurred.
Explain what the integrating centre is in relation to the reflex arc.
One or more regions of grey matter within the CNS acts as an integrating centre. In the simplest type of reflex, the integrating centre is a single synapse between a sensory neuron and a motor neuron.
Differentiate between monosynaptic reflex arc and polysynaptic reflex arc.
A reflex pathway having only one synapse in the CNS is termed as monosynaptic reflex arc.
A polysynaptic reflex arc involves more than two types of neurons and more than one CNS synapse.