Unit 3 From PPQs Flashcards
Statistically significant difference
Error bars do not overlap
Negative correlation
One factor increases, the other decreases
One factor increases, the other decreases
Negative correlation
Positive correlation
One factor increases, the other does too
One factor increases, the other does too
Positive correlation
Scattergraph reliability
Not reliable if many points lie far from line of best fit
Not reliable if many points lie far from line of best fit
Scattergraph reliability
Advantages of in vivo
Allows possible side effects to be shown
Allows effect of the drug/treatment on whole organism to be shown
Purpose of including a control
Comparison between drug and absense of drug
Gives baseline to measure the effect of the drug against
Comparison between drug and absense of drug
Gives baseline to measure the effect of the drug against
Purpose of placebo
Issue with patients administering drugs themselves in a drug trial
Decreases reliability as they may forget or not inject correctly
Purpose of randomised block design
Control confounding variables
Downside of randomised control groups
More time consuming
Stratified sampling
Population divided into categories and sampled proportionally
Population divided into categories and sampled proportionally
Stratified sampling
Why don’t placebos work for animals
They have no expectation
Reducing harm when using animals
Refinement - harm minimised
Reduction - minimum number of animals for validity
Do you need controls for each treatment
Yes if there is a different number of participants in each group
Review article
Compiles summarises of recent research in a particular field
Compiles summarises of recent research in a particular field
Review articles
Downside of observational studies
Cannot show causation
Accurate
Data close to true value
Data close to true value
Accurate
Precise
Dats has little variation
Data has little variation
Precise
Reliable
Replicates have consistent values
Replicates have consistent values
Reliable
Valid
Controlling variables
Controlling variables
Valid
Systematic sampling
Members of a population are selected at regular intervals
Members of a population are selected at regular intervals
Systematic sampling
Ecological sampling
Splitting up area and choosing random spots with randomised number generator
Splitting up area and choosing random spots with randomised number generator
Ecological sampling
Random sampling
Members of population have equal chance of selection
Members of population have equal chance of selection
Random sampling
Confidence interval
Indicates variability of data around mean
Indicates variability of data around mean
Confidence interval
“Statistically significant difference”
Must say increase or decrease!
Pilot study
Allows modifications of experimental design
Allows modifications of experimental design
Pilot study
Representative sample must have what
Same mean as population as a whole
Purpose of double blind design
Prevent bias
Confounding variable
Any variable besides the independent that may affect dependant variable
Any variable besides the independent that may affect dependant variable
Confounding variable
Experiment that is developing a technique within a larger investigation
Pilot study
Ethical considerations when using humans
Informed consent
Right to withdrawal data
Confidentiality
Causes of negative result
Experiment carried out wrong
Hypothesis is wrong
Negative result
Finding no effecr
Positive control
Assesses the test validity
Checks the system can detect a positive result
Assesses the test validity
Checks the system can detect a positive result
Positive conrrol
Negative control
Checking false positives don’t occur
An absence of treatment
In vivo
Whole, living organism
In vitro
Preforming procedure in a controlled environment outside of a living organism
In vivo advantages and disadvantages
Provides data for effects in whole organism
Expensive and time consuming
Difficult to control variables
In vitro advantages and disadvantages
Simpler and less expensive
Interpretation of results is simpler
Difficult to extend results to whole organism or different species
Difficult to model complex interactions
More variation in population requires what
Larger sample size
Peer reviewed
Articles evaluated by experts in the field
Articles evaluated by experts in the field
Peer reviewed
Epidemiology
Study of outbreak and spread of diseases
Study of outbreak and spread of diseases
Epidemiology