Unit 3 - All Key Areas Flashcards
Scientific Cycle
1) observation, 2) construction of a testable hypothesis, 3) experimental design, 4) gathering, recording, analysis of data, 5) evaluation of results, 6) conclusions , 7) the formation of new hypotheses where necessary.
Null Hypothesis
is a hypothesis that says there is no statistical significance between the two variables.
Refine, Reduce, Replace
Three Rs of animal studies
Refine
Ensuring competence in the experimental technique by reducing human error
Reduce
Using fewer animals in an animal study
Replace
Using a different type of animal in an animal study
Peer review
Most scientific publications use peer review. Specialists with expertise in the relevant field assess the scientific quality of a submitted manuscript and make recommendations regarding its suitability for publication.
Pilot Study
1.to develop and/or practice protocols in order to 2.ensure validity of experimental design, 3.check effectiveness of techniques, 4.find a suitable range of values for 5.identify and control confounding variables, 6.identifying suitable numbers of the independent variable, 7. to check whether results can be produced in a suitable time frame.
Independent variable
Variable that is changed in a scientific experiment
Dependent variable
Variable being tested and measured in a scientific experiment
Confounding variable
Variable besides the independent variable that may affect the dependent variable
Distinct variable
Variables that are specific and unrelated to each other
Continuous variable
Variables that have a range of values
Quantitative data
Data that is measured (eg numbers)
Qualitative data
Data that is observed (eg colour)
Ranked data
Observations put into an order from smallest to largest
Parasite load
A measure of the number of parasite found within a host organism
Positive control
Treatment that is included to check that the system can detect a positive result when it occurs
Negative control
Provides results in the absence of a treatment
Precision
The closeness of repeated measurements to one another
Accuracy
Data, or means of data sets, are close to the true value.
Validity
Variables controlled so that any measured effect is likely to be due to the independent variable.
Reliability
Consistent values in repeats and independent replicates.
Multifactorial
Name given to an experiment which has more than one independent variable
In vitro
An investigation carried out using biological molecules or cells out with their normal biological system, e.g. cell culture
In vivo
An investigation carried out using a living organism, e.g. mouse model organism.