Unit 3 Flashcards
85% of nephrons- short loops of Henle
Cortical nephrons
15% of nephrons- longer loops of Henle
Juxtamedullary nephrons- primary site of urine concentration
Where fluid is filtered out of the blood and into the nephron
Glomerulus in the renal corpuscle (Bowman’s capsule)
Average UO
60ml/hr
The rate at which fluid filters from the blood into the Bowman’s capsule
Glomerular Filtration Rate
Major site of reabsorption in the nephron
Proximal tubule
Na is mainly reabsorbed in this part of the nephron
Proximal tubule
Known as the salt retaining hormone, also increases secretion of K
Aldosterone
Acts in the collecting tubules, which transmits urine from the nephron and concentrates urine/absorbs water
Antidiuretic hormone (ADH)
ADH is synthesized in the _____ and stored in the _____.
Hypothalamus, posterior pituitary
Angiotensin II is a potent ______
Vasoconstrictor
Acts in the distal tubule to increase reabsorption of Na and secretion of K
Aldosterone
Acts in the collecting tubules to concentrate the urine and reabsorb water
ADH
Two effects of ADH:
- vasoconstrictor blood vessels to increase BP
2. increases reabsorption of water to increase blood volume
Increased ADH causes increase of water in blood, low serum Na, edema, and concentrated urine
SIADH
The best way to measure GFR
Plasma creatinine
Reflective of renal function
GFR
Type of ARF where kidneys are normal but hypo perfusion of the kidney causes failure
Prerenal ARF
Type of ARF that occurs due to obstruction of urine
Postrenal ARF
Type of ARF that results from loss of renal function due to structural damage to the glomeruli and/or tubules
Intrinsic ARF
Increased levels of this denote a decreased renal clearance and decline in GFR
Creatinine
CKD-kidney damage with normal/increased GFR (GFR >90)
1
CKD-kidney damage with mild disease in GFR (GFR 60-89)
2
CKD-moderate decrease in GFR (GFR 30-59)
3
CKD-severe decrease in GFR (GFR 15-29)
4
CKD-kidney failure (GFR < or equal to 15 or dialysis)
5
Blood urea levels _____ with a high-protein diet, excessive tissue breakdown, or GI bleed
Rise
Kidneys receive _______ of CO for glomeruli to remove metabolic wastes and regulate body fluids and lytes
20-25%
Pushes water out of the capillary into interstitial spaces (30-40mmHg arterial, 10-15mmHg venous)
• Aka capillary hydrostatic pressure
• Rise in arterial or venous pressure increases capillary pressure
• Weight of gravity in dependent parts of the body
Capillary filtration pressure
Pulls water back into the capillary (28mmHg)
• Osmotic pressure generated by the plasma proteins that are too large to pass through the pores of the capillary wall
Capillary colloidal osmotic pressure
Opposes the movement of water out of the capillary (-3mmHg)
Interstitial hydrostatic pressure
Pulls water out of the capillary into the interstitial spaces (8mmHg)
• Reflects the small amount of plasma proteins that normally escape into the interstitial spaces from the capillary also pulls water out of the capillary and into the tissue spaces
Tissue colloidal osmotic pressure