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NU 560 - Adv. Pharmacotherapeutics > Unit 2 Exam > Flashcards

Unit 2 Exam Flashcards

1
Q

Side Effects of Macrolides

A

QTC prolongation
LFT abnormalities
GI upset

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2
Q

Examples of Macrolides

A

Azithromycin

Clarithromycin

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3
Q

Caution with Macrolides

A

Arrhythmias or heart disease.

Hx of cholestatic jaundice or hepatic dysfunction w/ prior use.

Interactions CYP3A4 - statins use same pathway, hold statins during treatment.

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4
Q

Sinusitis Treatment

A

-Intranasal corticosteroids
-Augmentin
-Clindamycin
-Cephalosporins
-Doxycycline
-Fluoroquinolones

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5
Q

Sinusitis Treatment with ABX

A

ABX after “watchful waiting” 7 days unless severe.

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6
Q

First Line Treatment of Sinusitis

A

Amoxicillin with/without clavulanate 5-10 days

With clavulanate for high risk of infection from amox resistant organism

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7
Q

Sinusitis Treatment w/ Allergy to PCN

A

Use doxycycline or respiratory fluoroquinolone

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8
Q

Considerations with Augmentin Use

A

Do not use in pts with cephalosporin (cefazolin, ceftriaxone) allergy because of cross-sensitivity reaction with PCN and cephalosporins

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9
Q

Antihistamine MOA

A

Blocks the release of histamine from mast cells and basophils in the nasal passageways and competitively antagonize histamine at the H1 receptor.

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10
Q

1st Gen. Antihistamines Ex.

A

Benadryl
Chlorpheniramine

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11
Q

2nd Gen. Antihistamine Ex.

A

Fexofenadine (Allegra)
Loratadine (Claritin)
Cetirizine (Zyrtec)

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12
Q

Intranasal Antihistamines

A

Azelastine (Astelin)
Olopatadine (Pantanase)

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13
Q

Considerations of 1st Gen. Antihistamine Use

A

Causes drowsiness/sedation - ON BEERS LIST

Contraindicated in breastfeeding

AVOID IN NEWBORNS - SIDS

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14
Q

Benadryl Caution

A

Caution in asthma, CV disease, increased IOP, BPH, and thyroid dysfunction.

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15
Q

Chlorpheriniamine Caution

A

Caution in narrow-angle glaucoma, bladder neck obstruction, BPH.

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16
Q

Considerations of 2nd Gen. Antihistamine Use

A

Less sedating, but caution in renal and hepatic impairment.

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17
Q

Allegra + Claritin Adverse Effects

A

Somnolence
Dry mouth
Pharyngitis
Dizziness

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18
Q

Zyrtec Adverse Effects

A

GI upset
Drowsiness
Headache
Nausea
Viral infection

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19
Q

Astelin Adverse Effects

A

Bitter taste
HA
Nasal burning
Pharyngitis
Dry mouth
Fatigue
Dizziness

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20
Q

Patanase Adverse Effects

A

HA
Cough
Epistaxis
Bitter taste
Dry mouth

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21
Q

Overall Antihistamine Considerations

A

Caution in elderly - d/t confusion, constipation, dizziness, dry mouth, urinary retention, sedation (1st gen).

ON BEERS LIST

2nd gen ineffective for cough d/t colds as they may induce dryness causing worsening congestion d/t impairment of mucous flow.

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22
Q

Decongestants MOA

A

Sympathomimetic agent that stimulate alpha + beta receptors causing vasoconstriction

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23
Q

Decongestant Examples

A

Topical - Afrin and phenylephrine

Oral - Pseudoephedrine

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24
Q

Topical Decongestant Considerations

A

Don’t use more than 2-3 days due to side effect of rhinitis medicamentosa (rebound congestion).

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25
Q

Oral Decongestant Considerations

A

Given at least 2 hours before bed.

ER form should not be crushed, broken, or chewed.

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26
Q

Decongestant Overall Contraindications

A

Narrow angle glaucoma
Severe uncontrolled HTN
CAD
Recent use of MAOI

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27
Q

Decongestant Adverse Effects

A

HTN
Increase HR
Palpitations
Insomnia
Tremors
Urinary retention (caution w/ BPH)
GI upset
Dizziness

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28
Q

Acute Bronchitis Treatment

A

Antitussives
Expectorants
Antibiotics
Antivirals

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29
Q

Acute Bronchitis Patho

A

Infection of the bronchial tree.

90% caused by viruses

Hallmark sign - dry, non-productive cough, followed by a moist productive cough.

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30
Q

Antitussive Ex.

A

Benzonatate - mild cough
Dextromethorphan - mild cough
w/ codeine or hydrocodone - severe cough

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31
Q

Expectorants Ex.

A

Guaifenesin - decreases thick secretions

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32
Q

Antibiotic Indication for Bronchitis

A

Hx of COPD
High fever/ cough over 4-6 days
>65 years w/ comorbid conditions (CAD, DM)

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33
Q

Antiviral Indications for Bronchitis

A

If caused by flu A or B

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34
Q

Treatment of CAP in pts w/ comorbidities

A

Amoxicillin-clav + macrolide

Cephalosporin + Macrolide OR doxycycline

Fluoroquinolone monotherapy

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35
Q

Treatment of CAP in pts w/o comorbidities

A

Amoxicillin 1g TID
Doxycycline 100mg BID
Azithromycin (Zpack)
Clarithromycin 500mg BID

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36
Q

Oseltamivir (Tamiflu) Considerations

A

Rec within 48 hrs of symptoms onset

Can be used as prophylaxis for up to 6 weeks during a community outbreak

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37
Q

Tamiflu Considerations

A

Dosage adjustment with reduced kidney function.

Not recommended in ERSD.

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38
Q

Tamiflu Adverse Effects

A

N/V/D

Can feel worse taking tamiflu

Only really used for people at risk of hospitalization.

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39
Q

Theophylline Adverse Events

A

Tachycardia
Restlessness
Insomnia
N/V
GERD
Seizures

***Potential for life-threatening cardiac arrhythmias

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40
Q

Theophylline Med Class

A

Methylxanthines

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41
Q

Leukotriene Modifiers Indications

A

Asthma
Allergies

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42
Q

Leukotriene Receptor Agonists Ex.

A

Montelukast (Singulair)
Zafirlukast

“-lukast”

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43
Q

5-Lipoxygenase Inhibitors Ex. (Leukotriene modifier)

A

Zileuton

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44
Q

Montelukast (Singulair) Considerations

A

Black box warning - Serious behavior and mood related changes.

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45
Q

Zafirlukast Considerations

A

7 years and up

Metabolized by CYP450 enzyme

Adverse events - pharyngitis, HA, rhinitis, gastritis.

Rare liver failure resulting in death or liver transplant - monitor LFTs q 2-3 months***

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46
Q

Zileuton Considerations

A

12 years and up

Metabolized by CYP450 isoenzyme

Adverse events - Dyspepsia, abd pain, and nausea.

Monitor LFTs before treatment, once a month for 3 months, and once q 2-3 months***

Increases theophylline levels and PT/INR

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47
Q

Quick Relief Treatment Recommendations for Asthma

A

Short-acting beta agonists (SABA)

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48
Q

SABA Ex + Onset

A

Albuterol
Levalbuterol

Onset 10 mins, last 3-4 hours

May be repeated q 20 mins for 1 hr, then q 3-4 hours for 24-48 hrs.

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49
Q

Short-Acting Muscarinic (anticholinergic) Antagonist Mechanism of Action

A

Blocks acetylcholine muscarinic receptors, decreasing cGMP which relaxes airway smooth muscle and increases bronchial ciliary activity, therefore decreasing mucous secretions.

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50
Q

SAMA Ex + Onset

A

Ipratropium Bromide (Atrovent)

Onset - 15 mins, duration 2-5 hrs.

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51
Q

Gold Group D Option 1

A

Daily LABA/LAMA

Ellipta, Genuair, Respimat

“REG”

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52
Q

Gold Group D Option 2

A

Daily ICS/LABA

Advair, Airduo, Breo, Dulera and Symbicort

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53
Q

Gold Group D Option 3

A

Daily ICS/LABA/LAMA

Can add theophylline, phosphodiesterase-4 inhibitor, macrolide abx or quad therapy (ICS + LAMA + LABA + roflumilast = Trelegy)

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54
Q

LABA Ex.

A

Salmeterol

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55
Q

LABA Black Box Warning

A

Black box warning - increased asthmas related death.

MUST be used with ICS

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56
Q

LABA Adverse Events

A

Tachycardia
Tremors
Nervousness
Dizziness
Hyperglycemia

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57
Q

LABA Contraindications

A

Hypersensitivity

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58
Q

LABA Cautions

A

Known cardiac disease
DM
Glaucoma
Seizure dx

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59
Q

Combo ICS/LABA Ex

A

Advair Diskus (fluticasone/salmererol)

Breo (Fluticasone/vilanterol)

Dulera (Mometasone/formoterol)

Symbicort (Budesonide/Formoterol)

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60
Q

Namenda (NMDA) MOA

A

Blocks activation and overstimulation of NMDA receptor during glutamate abundance inhibiting neuronal degeneration.

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61
Q

Goals of Drug Therapy for AD

A

To maintain and maximize the pt’s functional ability, quality of life, and independence for as long as possible while minimizing adverse events and cost.

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62
Q

Meds to Control Non-cognitive Symptoms

A

Antipsychotics Agents
Benzodiazepines
Antidepressants

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63
Q

Antipsychotic Agents Ex.

A

Haloperidol (Haldol) - Typical antipsychotic

Risperidone (Risperdal) + Olazapine (Zyprexa) - Atypical antipsychotic

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64
Q

Haloperidol (Haldol) Considerations

A

High side effect profile, including risk for extrapyramidal symptoms (Parkinsonian symptoms)

Last resort!

65
Q

Antipsychotic Black Box Warning

A

Increased risk of death in dementia related psychosis associated with increased risk of stroke

66
Q

Benzodiazepine Use in AD

A

PRN for anxiety and episodic agitation

Start at lowest dose, use sparingly

Short Acting preferred - Ativan/Xanax

Adverse effects = falls, sedation, delirium

67
Q

Antidepressant Use in AD

A

High incidence of depression associated with AD

Can improve QOL

SSRIs preferred - Lexapro/Zoloft

68
Q

1st Line Treatment of Mild to Moderate AD

A

Cholinesterase Inhibitors

69
Q

1st Line Treatment of Moderate to Severe AD

A

NMDA receptor agonist (may be used WITH cholinesterase inhibitor)

70
Q

2nd Line Treatment of Moderate to Severe AD

A

Trial of second cholinesterase inhibitor.

71
Q

Cogentin Contraindications

A

Narrow-angle glaucoma

72
Q

Cogentin Adverse Events

A

N/V
Constipation
Dizziness
HA
Peripheral edema
Insomnia
Orthostatic hypotension
Dyskinesias

73
Q

Cogentin Special Considerations

A

Avoid with KCl - can increase risk of ulcers

Concomitant use of glucagon can increase GI adverse effects

Avoid use with other anticholinergics - can cause additive side effects

74
Q

Treatment of Motor Symptoms in PD

A

Anticholinergics
Amantadine
Monoamine Oxidase-B (MAO-B) Inhibitors
Dopamine Agonists
Levodopa
Carbidopa/Levadopa
Catechol-O Methyltransferase Inhibitors (COMTIs)

AACC-MDL

75
Q

Anticholinergic Ex.

A

Trihexyphenidyl (Artane)
Benztropine (Cogentin)

76
Q

Amantadine Ex.

A

IR (Symmetrel)
ER cap (Gocvri)
ER Tab (Osmolex)

77
Q

MAO-B Ex.

A

Slegiline (Eldepryl)
Basagiline (Azilect)
Safinamide (Xadago)

78
Q

Dopamine Agonists Ex.

A

Pramipexole (Mirapex)
Ropinirole (Requip)
Rotigotine (Neupro)
Apomorphine (Apokyn)

79
Q

Carbidopa/Levadopa Ex.

A

IR (Sinemet CR)
CR (Sinemet CR)
ER (Rytary)

80
Q

COMTIs Ex.

A

Entacapone (Comtan)
Tolcapone (Tasmar)

“-capone”

81
Q

Non-motor Symptoms in PD

A

Depression
Psychosis
Dementia
Insomnia
Autonomic/other issues (Hypotension, drooling, constipation).

82
Q

Treatment of Depression in PD

A

Pramipexole (Mirapex)
Venlafaxine (Effexor)
TCAs (Elavil)
Dopaminergic drugs (Wellbutrin)

83
Q

Treatment of Psychosis in PD

A

Clozapine (Clozaril) - preferred
Quetiapine (Seroquel) - most effective
Donepezil (Aricept)
Rivastigmine (Exelon)
Ziprasidone (Geodon)

84
Q

Treatment of Insomnia in PD

A

Rotigotine (Neupro)

85
Q

Treatment of Hypotension in PD

A

Fludrocortisone (Florinef)
Indomethacin
Droxidopa

86
Q

Treatment of Drooling in PD

A

Sublingual atropine drops
Glycopyrrolate
Botulinum toxin injections

87
Q

Treatment of Constipation in PD

A

Stimulant laxatives
Stool softener

88
Q

Amantadine MOA

A

Binds to and blocks N-methyl-D-aspartate (NMDA) glutamate receptors and increases the release of dopamine.

Used for dyskinesia.

89
Q

Levadopa MOA

A

Dopamine precursor, cross the BBB, converts via dexarboxylation (L-DOPA decarboxylase) to dopamine and stored in the presynaptic neurons until stimulated for release.

90
Q

Carbamazepine (Tegretol) Serious Side Effects

A

Hypersensitivity to medication/TCAs, bone marrow suppression, recent use of MOAIs

Inducer of several CYP pathways, pregnancy category D, can lead to hyponatremia in older adults.

Blood dycrasias, SIADH, cardiac conduction issues, SJS, and DRESS.

91
Q

Carbamazepine (Tegretol) Black Box Warning

A

Risk of toxic epidermal necrosis/SJS, aplastic anemia, and agranulocytosis.

Screen for human leukocyte antigen (HLA)-B*1502 allele - seen in Asian decent

92
Q

Hydantoins (Phenytoin, Fosphenytoin) Adverse Effects

A

Lateral nystagmus, ataxia, lethargy, acne, increased body hair, arrhythmia, gingival hyperplasia.

Check levels with concern for these SEs

Contraindicated in HB and SB

93
Q

Acute Treatment of Status Epilepticus

A

Benzodiazepines

94
Q

Benzodiazepines MOA

A

Depresses all levels of the CNS including the limbic system and reticular formation, probably through the increase action of GABA

95
Q

Benzos Used in Status Epilepticus

A

Lorazepam

Diazepam (can also be rectal gel)

MUST BE IV

96
Q

Preventative/Prophylactic Treatment for Cluster Headaches

A

Verapamil IR
Lithium
Melatonin
Warfarin
Galcanezumab

GLMVW

97
Q

Prophylactic Treatment for Cluster Headaches

A

1st line - TCAs
2nd line - SNRI (Venlafaxine) or atypical antidepressants (Mirtazapine)

98
Q

Amitriptyline (Elavil) for TTH

A

1st line, GOLD standard for TTH

Given at bedtime

99
Q

Amitriptyline (Elavil) Adverse Events

A

Weight gain
Anticholinergic effects
Drowsiness

100
Q

Amitriptyline (Elavil) Cautions

A

Use in caution in patients with Hx of CVD, BPH, glaucoma, urinary retention, DM, CNS drugs/alcohol, elderly.

101
Q

Amitriptyline (Elavil) Black Box Warning

A

Risk of suicidal ideation in pts <24 years old with major depressive disorder or other psychiatric disorders.

102
Q

Venlafaxine (Effexor) Adverse Effects

A

Nausea
Somnolence
Sexual dysfunction
Sweating
Nervousness

103
Q

Venlafaxine (Effexor) Special Considerations

A

Multiple drug interactions

Use in caution in older adults

104
Q

Mirtaxapine (Remeron) Adverse Events

A

Somnolence
Increased cholesterol
Dry mouth
Weight gain
Constipation

105
Q

Mirtaxapine (Remeron) Special Considerations

A

Use caution in seizure disorder, hepatic/renal dysfunction, older adults

106
Q

1st Line Prophylaxis for Migraines

A

Anticonvulsants (Valporic acid, topiramate)
Beta blockers (propranolol, metoprolol, timolol)
TCAs (Amitriptyline)
SNRI (Venlafaxine)

ABTS

107
Q

2nd Line Prophylaxis for Migraines

A

CCBs (Verapamil)
Injectable CGRP Inhibitors (Amovig, Ajovy, Emgality, Vyepti)

108
Q

3rd Line/Alternative Prophylaxis for Migraines

A

Botox

109
Q

Second Line Treatment Options for Migraine

A

Triptans
Ditans
CGRP receptor antagonists
Ergot Derivatives
Barbiturates
Opioids
Steroids
Antiemetic Agents

110
Q

Triptans Examples

A

Sumatriptan
Zolmitriptan
Rizatriptan
Eletriptan
Fovatriptan

“-triptan”

111
Q

Ditans Examples

A

Lasmiditan (Reyvoew)

“-ditan”

112
Q

CGRP Receptor Antagonist Examples

A

Ubrogepant (Ubrelvy)
Rimegepant (Nutec)

“-gepant”

113
Q

Ergot Derivatives Examples

A

Ergotamine Tartrate (Ergomar)
Dihydroergotamine/DHE (Migranal)
Ergotamine-caffeine (Cafergot)

“Ergot”

114
Q

Barbiturates Examples

A

Fioricet (butalbital/caffeine/acetaminophen)

Forinal (butalbital/caffeine/aspirin)

“Bit”

115
Q

Opioids Examples

A

Butorphanol Tartrate
Tramadol
Acetaminophen + codeine

116
Q

Steroid Examples

A

Dexamethasone

117
Q

Antiemetic Agent Examples

A

Proclorperazine
Metoclopramide
Droperidol - QT prolonging

118
Q

Contraindications/Considerations to Triptan Therapy

A

Should not be used more than 9 days per month

Should not be used within 24 hours of other vasoconstricting drugs (ex. ergotamine).

Avoid in patients with basilar, hemiplegic, reigonal migraines.

Avoid in patients with CAD, CV disease, severe PVD.

STRONGLY contraindicated in pregnancy .

Not indicated for children HOWEVER safety and efficacy for age 12-17 have been demonstrated for nasal and oral dosages.

119
Q

Contraindication for Zolmitriptan

A

Patients with Wolf-Parkinson-White (WPW) sydrome

120
Q

Medication Overuse Headache (MOH)

A

Headache recurs as each dose of med wears off causing the patient to take another analgesic and thus continuing the cycle of pain.

121
Q

MOH Diagnosis

A

Treating more than 2 headaches with OTC analgesics or other abortive medications per week for migraine or TTH can lead to the development of chronic daily headaches.

122
Q

Treatment of MOH

A

With holding all OTC analgesics for 1-2 weeks.

Identify triggers and encourage healthy lifestyle.

123
Q

Bisphosphonate Therapy Education

A

AM dosing on an empty stomach - absorption decreases with food.

Must be taken whole w/ 8oz of water and remain upright for 30-60 mins.

Daily, weekly, and monthly formulations.

Omit in patients with GERD d/t risk of esophagitis.

Monitor via DEXA scans, if scan is good, pt can take holiday from medication.

124
Q

1st Line Acute Gout Treatment

A

NSAIDs - Naproxen, indomethacin, sulindac

Systemic corticosteroids

Colchicine - must be given within 24-48 hrs.

125
Q

2nd Line Acute Gout Treatment

A

Switch to an alternative 1st line

Do not mix NSAIDs with steroids

126
Q

1st Line RA Bridging Treatment

A

NSAIDs or corticosteroids in ACUTE episode until DMARDs are therapeutic (most common is methotrexate).

127
Q

Other RA Bridging Treatments

A

Glucocorticoids are used to rapidly suppress inflammation and relieve symptoms.

128
Q

Treatment of Fibromyalgia

A

SNRIs - start low
SSRIs
TCAs

Cognitive Behavioral Therapy
Exercise

129
Q

Examples of SNRIs for Fibromyalgia

A

Duloxetine (Cymbalta)
Milnacipran (Savella)
Venlafaxine (Effexor)

130
Q

Examples of SSRIs for Fibromyalgia

A

Fluoxetine (Prozac)
Sertraline (Zoloft)
Escitalopram (Lexapro)

131
Q

Considerations for TCAs in Fibromyalgia

A

Sedation, TD, orthostatic hypotension, weight gain, anticholinergic symptoms, QT interval prolongations, and arrhythmias.

Use caution in elderly.

132
Q

Psoriasis Treatment Considerations with Coal Tar (Cutar)

A

Odor, staining, photosensitivity, and folliculitis.

Use sunscreen.

Side effects = poor compliance

133
Q

Herpes Zoster Treatment Options

A

Acyclovir - 800 mg x5 per day for 7-10 days
Famciclovir - 500 mg x3 per day for 7 days
Valacyclovir - 1 g x3 per day

134
Q

Systemic Antivirals Considerations

A

Very effective against herpes virus

Recommended for adolescents, adults, and high-risk patients.

Not indicated for “healthy children” (<12)

135
Q

Oral Terbinafine (Lamisil) Contraindications for Tinea Pedis (Toenail fungus)

A

Acute or chronic hepatic disease - check LFTs before start and 6-8 weeks after.

Interactions with Tagamet and antagonized by Rifampin

136
Q

Terbinafine (Lamisil) Adverse Effects

A

Elevation in AST/ALTs
Diarrhea
Dyspepsia
Rash
HA

137
Q

1st Line Impetigo Treatment

A

Topical mupirocin TID x7-10 days

Oral antibiotics

138
Q

Oral ATB for Impetigo

A

Broad PNC - Amox-Clav or Dicloxacillin
1st Gen Ceph - Cephalexin
PNC allergy - Clindamycin***

139
Q

Clotrimazole (Lotrimin) Topical Antifungal Considerations

A

Continue 1 week after infection clears.

NOT recommended during pregnancy or lactation

Avoid Ketoconazole in patients with sulfa-sensitivity

140
Q

Clotrimazole (Lotrimin) Adverse Events

A

Pruritis
Irritation
Stinging

141
Q

Considerations for Rx Systemic Corticosteroids for Contact Dermatitis

A

Initiate when dermatitis is widespread or resistance to topical preparations.

Rx as tapering dose

Take in morning to minimize insomnia

<2 week can lead to rebound dermatitis

142
Q

Contraindications and Caution with Systemic Corticosteroids

A

Contraindicated - pts with systemic fungal infections and receiving vaccination.

Caution - TB, hypothyroidism, cirrhosis, renal insufficiency, HTN, osteoporosis, diabetes.

143
Q

Systemic Corticosteroid Adverse Effects

A

GI upset
Mood swings
Sleep disturbances

Decreased efficacy if administered with barbiturates or rifampin

144
Q

Treatment of Dermatitis on the Face and Intertriginous Regions

A

Use low potency steroids - think skin, so steroids will be absorbed faster and have a stronger effect.

145
Q

Isotretinoin (Accutane) Rx Considerations

A

Only 30 days can be prescribed at a time.

Use 2 forms of contraception.

Before start - CBC, chem, fasting lipids and 1 month after.

Pregnancy should be avoided for 1 month after therapy is dc’d.

Should not be used in adolescents who have not finished growing, drug may cause premature close of the epiphyses.

146
Q

Accutane Black Box

A

May cause increase in aggressive or violent behaviors or suicidal ideation.

147
Q

Accutane Contraindications

A

Teratogen - serious birth defects

Prescribers must be registered in SMART program.

148
Q

Accutane Adverse Effects

A

Teratogenicity
Elevated trigs
Dry skin and mucous membranes
MS aches
Corneal opacitities

149
Q

1st Line Treatment for Acne

A

Topical Thearpy

150
Q

Topical Medications for Acne

A

Retonoic Acid (Tretinoin)
Adapalene Gel (Differin)
Taxarotene Gel (Tazorac) - Retinoid prodrug

Skin care is most important

151
Q

Role of Oral Contraceptives in Acne Treatment

A

Contraceptives that contain ethinyl estradiol, levonorgestrel, and norgestimate or drospirenone.

Effective due to decrease of testosterone production.

152
Q

MRSA and Superficial Bacterial Infection Treatment

A

Vancomycin
Daptomycin
Linezolid (Zyvox)

Mupriocin (nostrils)

153
Q

Treatment of CA-MRSA

A

Trimethoprim/Sulfamethoxazole (Bactrim)

154
Q

Topical Preparation Absorption Rate Factors

A

Amount of agent applied

Surface area of the application

Length of application time

Frequency of the applicaiton

Application to broken skin/erosions

Choice of vehicle used

Thickness of the stratum corneum

155
Q

1st Line Treatment of Rosacea - Topical

A

Metronidazole (MetroGel, Noritate)
Azelaic Acid (Finacea)
Sodium Sulfacetamide w/ Sulfur
Sulfacetamide, Sulfur, and Urea

156
Q

2nd Line Treatment of Rosacea - Oral ATB

A

No improvement in 6 weeks

After 2 weeks of therapy, dose is reduced by 50% and then after 6 weeks, oral ATB is dc’d.

Topical treatment is continued indefinitely.

157
Q

Oral ATB for Rosacea

A

Tetracycline
Doxycycline (Vibramycin, Monodox, Doryx)
Erythromycin
Trimethoprim/Sulfamethoxazole (Bactrim)

TDTE

158
Q

3rd Line Treatment of Rosacea

A

If no improvement after 6 weeks

Start Isotretinoin (Accutane) or refer to dermatology.

NU 560 - Adv. Pharmacotherapeutics (5 decks)

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