Unit 1 Exam Flashcards
Phases of Clinical Trials
Pre-Clinical Trials
Phase I-IV
Pre-Clinical Trials
Animal testing
Phase I
20-100 healthy individuals
Focuses on pharmacodynamics
Most effective administration routes and dosage ranges are determined.
Occurs inpatient (overnight/weekend).
Phase II
Up to several hundred people with the disease the drug is intended to treat.
Same testing focus as phase I.
Performed outpatient. Serum levels, tolerance, side effects, and effectiveness are monitored.
Approval of the application means the drug can be marketed, but only by the company seeking the approval.
Phase III
1000 of patents
It begins once FDA determines that the drug causes no apparent side effects and that the dosing range is appropriate.
Double-blind research methods.
Most risk is discovered in this phase.
Either approved or rejected by FDA after this phase.
Phase IV
Post-marketing studies/surveillance.
Objectives:
1. Compare drugs to other drugs on the market.
2. Monitor long-term effectiveness and impact on QOL.
3. Analyze cost effectiveness.
Drugs can be taken off the market due to additional findings about the drugs and their side effects.
What is the Controlled Substances Act of 1970?
From the FDA
A way to categorize risk for addition and abuse.
What is the Controlled Substances Act of 1970?
From the FDA
A way to categorize risk for addition and abuse.
Drug Schedule
I, II, III, IV, V
Example of Schedule I Drugs
Heroin, cocaine
Highest abuse / addictive potential
Example of Schedule II Drugs
Morphine, dilaudid, methadone
Short interval of use
Example of Schedule III Drugs
Percocet
Low abuse potential / high addictive potential
Example of Schedule IV Drugs
Benzos
Low abuse / some addiction
Those who “NEED” it are likely to abuse it
Example of Schedule V Drugs
Robotussin w/ codeine, adderall
Least abuse / lowest addition
How to monitor adherence to therapy?
Lab testing
Pill count
Patient diary (BP or BG journal)
Therapeutic Window
Range of drug concentration in the blood between a minimally effective level and toxic level.
Pharmacogenomics
Personalized medicine
How genetic variations impact response to therapy
Single nucleotide polymorphism
Enables targeted therapy/focus resources
Expedites clinical improvements
Targeted risk reduction strategies
Area of tremendous amount of research.
Pharmacotherapeutics
Utilization of drugs to diagnose, prevent, or treat disease or illness.
Includes pharmacokinetics and pharmacodynamics.
Pharmacokinetics
What the body does to the drug.
Pharmacodynamics
What the drug does to the body.
Pharmacokinetics includes what 4 phases?
Absorption
Distribution
Metabolism
Excretion
Gender and Pharmacokinetics
Women have a higher % body fat which can alter the pharmacokinetics of different drugs.
Most drugs are tested more on men than women so need to consider hormonal changes and different patterns of fat.
Absorption
How administered drugs are absorbed into the body.
What affects absorption?
Bioavailability and route of administration
Bioavailability
The rate and extent drugs are absorbed from substances and are available at the site of action.
The fraction or % of an administered dose of a drug that reaches the circulation in its unmetabolized form.
What affects bioavailability?
First pass effect
Prodrugs
Drug formulation (Ex. ER vs. IR)
GI motility
Blood flow
First Pass Affect
Metabolism that occurs in the liver before passing into circulation.
PO drugs are subject to first pass effect.
Pro-Drugs
Drugs w/ no biological activity itself
Once metabolised in the liver, it becomes an active metabolite.
Precursor to active drug.
Drug Formulation
IR - Delivered to GI tract quickly for quick onset of action.
ER - Extends activity of drugs in the body to level out the high peaks to low troughs of concentrations.
EC - Slow drug to be dissolved in the intestines rather than the stomach.
GI Motility
Gastric emptying - Increases absorption and bioavailability.
Decreased intestinal motility - Greater absorption and bioavailability.
Increased intestinal motility - Less absorption and bioavailability.
Blood Flow
Based on adequate perfusion
Gut and intestinal perfusion is important for absorption.
Shock states affect blood flow and delivery of drugs.
Route of Administration
Enteral vs. Parenteral (all routes not involving GI)
Distribution
How drugs are distributed to the site of action
What affects distribution?
Blood flow
Lipid or water solubility
Protein binding
Passive Diffusion
High-concentration to low-concentration
No energy needed
Facilitated Diffusion
High-concentration to low-concentration
Via carrier proteins
Active Transport
Low-concentration to high-concentration
Utilizes ATP
Protein Binding
After absorption, drugs circulate through the body as unbound (free drug) or bound to proteins (commonly albumin).
Drug unbound (free drug) = Biologically active.
Low albumin states can result in toxicity.
ATBs have higher affinity to albumin than warfarin -> free warfarin -> increased INR.
Metabolism
Biotransformation of the drug from active form to inactive form.
Preparation for elimination.
What organ is primarily responsible for metabolism?
Liver
Also kidneys and intestines
Two Phases of Metabolism
Phase 1 - Enzymatic process that involves oxidation or reduction (hydrolysis).
Phase 2 - Adding a conjugate to the parent drug or metabolized drug to further increase water solubility and enhance excretion.
Cytochrome P-450 System (CYP450)
Composed of superfamilies of more than 100 enzymes.
3 families (15 enzymes) are responsible for drug metabolism in about 90% of cases.
Drugs may be substrate, inducer, or inhibitors of the CYP450 system.
Inducer
Stimulates production of enzymes which increase the amount of enzymes available for metabolism.
Ex. Phenytoin, Rifampin, St. John’s Wort
Inhibitors
Inhibits the production of CYP enzymes, decreasing the metabolism of drugs and increasing circulating levels.
Ex. Grapefruit juice, Azoles, Protease inhibitors.
Excretion
Removal of inactive drug from the body.
Primary organ of excretion
Kidneys
Important to know GFR to help dose drugs.
Other areas include lungs, skin, and GI tract.
Half-Life (t 1/2)
Time required for 50% of a drug to be eliminated from the body.
Ex. If t 1/2 is 10 hrs, then each 10 hrs, 50% of what is remaining will be eliminated.
Drug is considered fully eliminated after 4-5 half-lives.
Factors Interfering w/ Elimination
Renal failure → Increased t1/2 → dose less
Hepatic failure → Impacts prodrugs + CYP450 enzymes → increases t1/2
Exercise (regular vs. intermittent) → Impacts blood flow, GI motility, and body temp.
Factors affecting pharmacodynamics
Receptor abundance
Receptor affinity
Post-receptor changes and sensitivities
Types of receptors
Agonists
Antagonists
Agonist
Creates a response
Dose dependent
Depended on receptor sensitivity
Antagonist
Creates no biological response
Blocks receptors from agonists
Compete for receptor sites
Noncompentative sites.
Autonomic Nervous System receptors
Alpha-1, alpha-2, beta-1, beta-2
Flight or fight
Neurotransmitter is NE
Parasympathetic Nervous System Receptors
Cholinergic and muscarinic receptors
Neurotransmitter is ACH (acetylcholine)
How is pharmacotherapy different in the pediatric population?
Each property of pharmacokinetics is different.
Factors affecting drug delivery in pregnant women
Increased blood volume (30-50%), increased body water (~8lbs), and increased circulation -> Dilutional effect
Decreased serum albumin -> Increased free drug.
Increased progesterone + decreased Gi motility -> Increased absorption + bioavailability.
Maternal fat distribution + GI pH increased.
Factors promoting placental transfer
Lipid solubility.
Smaller, lighter molecules.
Unbound or “free drug”.
Factors Inhibiting placental transfer
Highly ionized molecules (requires active transport).
Larger, heavier molecules.
Drugs with high protein binding.
Beers Criteria
Guidelines for inappropriate medication use in older adults.
American Geriatric Society
Medicare Part-D may not pay for some of these meds.
Commonly prescribed meds are on that list.
Ex. Alpha-blockers prescribed for BPH.
Active Immunization
Administration of all or part of a microorganism or modified product of that microorganism.
Live or attenuated.
Evokes a natural immune response that mimics the body’s response to natural infection.
Ex. PNA vaccine/MMR
Passive Immunization
For people who have been exposed or have the potential to be exposed to specific infectious agents.
Administration of a preformed antibody when the recipient has a congenitally acquired defect or is immunodeficient.
Ex. Rabies
Vaccination Rates Across Lifespan
3 y/o = 90% - Infants/peds consistently visit their PCP.
18-64 y/o = 33-70%
Most vaccine series end around 11/12 y/o
Pediatric PNA Vaccine
Under 2 years, receive 4 doses of PCV-13