Unit 2 Flashcards
Drug absorption is based upon what two things?
The pH of the drug and the pH of the area where the drug winds up.
Acid stable
Drug is not broken down in an acidic environment
Acid labile
Drug will break down in an acidic environment
Delayed release
Physically delays the release of any medicine for 6-8 hours
Sustained release
Starts releasing medication immediately, and gradually releases over a 12 hour period
Epidermic base
(Lotions)
No, or very slight absorption through intact skin
Endodermic
(Ointments)
Allows penetration into deeper skin layers
Diadermic
(Liniments)
Allows for penetration through all skin layers
pH of stomach
2
pH of intestine
7.2 - 7.6
Acidic drugs are ___ 7
below
Alkaline drugs are ___ 7
above
effective dose
The amount of the test drug causes a defined effect in 50 percent of the animals that receive it.
lethal dose
The amount of the test drug that kills 50 percent of the animals that receive it.
therapeutic index
drug dosage that produces the desired effect with minimal or no signs of toxicity. Determined by comparing the drug’s LD to the ED
