Unit 1-Intro to Nutrition and Digestive System//Unit 2- DRI, Dietary Guidelines and Nutritional Labeling Flashcards
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Basis of health = ??
- Free from ________
- Optimal state of the ________
- physical and mental
What is Nutrition?
Nutrition is the science of _______
disease
body
FOOD
Unit 1: Intro to Biochem Nutrit. and the Digestive System
“For the health provider, ______ ______is the first step in the nutrition care process. To implement a successful
nutrition plan, the _________ must include key elements of the patient’s clinical or medical history, current complaint, anthropometric measurements, biochemical
and laboratory values, information on medication and herbal supplement use for potential food-drug interactions, plus a thorough food and nutrition intake history.”
nutrition assessment
assessment
Unit 1: Intro to Biochem Nutrit. and the Digestive System
\_\_\_\_\_\_\_\_\_- a substance that provides nourishment essential for growth and the maintenance of life EX. 1-Basal metabolism 2-Growth 3-Health maintenance 4-Disease prevention 5-Reproduction
NUTRIENT
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Macronutrients: daily requirement in ___
EX. Carbohydrates– Proteins–Fat –Water
• Micronutrients: daily requirement in _________
EX. Vitamins–Minerals
grams
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Micronutrients: Vitamins
Fat soluble: Vitamins A, D, E, K
Water-soluble:
B-complex X 8???
Vitamin C (ascorbic acid)
B1(thiamin) B2(riboflavin) B3(niacin) B5(pantothenic acid) B6(pyridoxine) B7(biotin) B9(folate) B12 (cobalamin)
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Micronutrients: Minerals
Ions, salts, and organic compounds
Major minerals: X 7 =????
Daily requirement > 100 mg
Accounts for > 0.03% total body weight
Ca, P, Na, K, Mg, S, Cl
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Trace minerals: X 17!!
Daily requirement =??
Accounts for
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Three-step model of nutrition =??
- Ingestion
- Digestion
- Utilization
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Gastrointestinal Tract (GIT)
• ______ macronutrients (protein, carbohydrates, lipids, water, and ethanol) from ingested foods and beverages
• _______ necessary micronutrients and trace elements
• Serves as a physical and immunologic barrier
• Is one of the largest organs; has the greatest _____ ______and the greatest number of________ cells
Extracts
Absorbs
surface area
immune
Unit 1: Intro to Biochem Nutrit. and the Digestive System
The Health of the Body Depends on the Health of the GIT
• After only a few days of starvation, the GIT _______
• The cells lining the GIT have a lifespan of only 3
to 5 ______
• Due to their high metabolic activity, the cells lining the GIT are more susceptible to________ by:
– Nutrient deficiency
– Damage from toxins and irradiation
– Disruption in blood flow
• Optimum function of the GIT depends on a __________ supply of foods, rather than on consumption of large amounts of foods interrupted by prolonged fasts
atrophies
days
damage
constant
Unit 1: Intro to Biochem Nutrit. and the Digestive System
The Digestive System= __% to __% of the diet is absorbed
___ ________: key role in digestion and absorption
*Intestines: __ m long-Villi and microvilli or brush border
92 97
Small intestine
7
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Sites of Secretion, Digestion, and Absorption —1
1–Stomach
- _____secretions contain hydrochloric acid, pepsin gastric lipase, mucus, intrinsic factor, and gastrin
- Food becomes ______ _________ (50% H2O)
- ______ reduces the number of microorganisms (pH 1-4)
- Solid meal empties in 2 to 3 hours
WHICH ORDER??
Gastric
semiliquid chyme
Acid
(Liquid-C-P-F-Fiber)
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Sites of Secretion, Digestion, and Absorption–2
2–Small Intestine
*Primary organ of _____ and ______absorption, _____
neutralization
*Surface area is increased by length, folds, villi, and microvilli
*Fats are emulsified, digested, and absorbed in ____
nutrient
water
acid
micelles
Unit 1: Intro to Biochem Nutrit. and the Digestive System
Sites of Secretion, Digestion, & Absorption—3/3
3–Large Intestine
*____ m long: cecum, colon, and rectum
*Nutrients formed here: vitamin __, Biotin (vitamin B7),
cobalamin (vitamin B12), thiamin (vitamin B1), riboflavin
(vitamin B2)
*Bacterial action to produce ______ and organic acids
*Colonic salvage: SCFA production through fermentation
*________ reabsorption
1.5
K
gases
Water
Unit 1: Intro to Biochem Nutrit. and the Digestive System
2 TYPES OF Transport Pathways Through the Cell Membrane
- DIFFUSION = SIMPLE DIFFUSION AND FACILITATED
- ACTIVE TRANSPORT = REQUIRES ATP
KNOW
Summary of Enzymatic Digestion and Absorption
SECRETION–Saliva in mouth
ENZYME–Ptyalin (salivary amylase)
SUBSTRATE–Starch
ACTION–Hydrolysis of α1–4 glycosidic bonds
FINAL PRODUCT–Dextrins, oligosac- charides
S--Gastric juice in stomach (HCl) E--Pepsin S--Protein A--Hydrolysis of peptide bonds F--Poly- peptides, amino acids &
E–Gastric lipase
S–Fats
A–Hydrolysis
F–Free fatty acids
Study slide 18–21
Asap
Hormones and Gastrointestinal Function x6
1–Gastrin–is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the _______ and aids in gastric motility. It is released by ___ cells in the pyloric antrum of the stomach. duodenum, and the pancreas.
stomach
G
Hormones and Gastrointestinal Function x6
2–Secretin–is a hormone that regulates water homeostasis throughout the body, and influences the environment of the duodenum by regulating secretions in the stomach and pancreas. Secretin is produced in the __cells of the __________, which are located in the crypts of Lieberkühn.
S
duodenum
Hormones and Gastrointestinal Function x6
3–Cholecystokinin (CCK)–s synthesized by __cells in the mucosal epithelium of the small intestine and secreted in the ________, the first segment of the small intestine, and causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively.
I
duodenum
Hormones and Gastrointestinal Function x6
4–GIP–It is synthesized by __cells, which are found in the mucosa of the _______ and the _________ of the gastrointestinal tract.
K
duodenum
jejunum
Hormones and Gastrointestinal Function x6
5–Motilin– is secreted by endocrine __cells (these are not the same M cells that are in Peyer’s patches) that are numerous in crypts of the small intestine, especially in the _________ and __________
M
duodenum
jejunum
Hormones and Gastrointestinal Function x6
6–Somatostatin–Somatostatin is secreted in several locations in the digestive system:
1–stomach
2–intestine
3–delta cells of the pancreas
Somatostatin will travel through the portal blood system, to the heart, then to systemic circulation, where it will exert its digestive system effects. In the stomach, somatostatin acts on the acid-producing parietal cells via G-coupled receptor to reduce secretion. Somatostatin also indirectly decreases stomach acid production by preventing the release of other hormones, including gastrin, secretin and histamine which effectively slows down the digestive process.
Know
Neuropeptide Hormones x7
• There are more than 100 peptide hormones
1– _________relaxes esophageal sphincter
2– _________decreases motility, contracts sphincters, inhibits secretions
3– __________increases motility, relaxes sphincters, stimulates secretions
4– ___________inhibits gastric emptying
GABA
Norepinephrine
Acetylcholine
Neurotensin