Unit 1 - Biochemistry in the Cell Flashcards

(73 cards)

1
Q

Distinctive Properties of Living Systems

A
  • complicated and highly organized
  • serve functional purposes
  • actively engaged in energy transformations
  • capacity for self-replication
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2
Q

Organisms capture energy in the form of?

A

special molecules

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3
Q

Organisms capture energy in the form of special molecules such as?

A

o ATP – Adenine Triphosphate
o NADPH – Nicotinamide Adenine Dinucleotide Phosphate

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4
Q

The Fidelity of Self-Replication Resides Ultimately in the Chemical Nature of?

A

DNA

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5
Q

DNA: Two complementary polynucleotide chains running in opposite directions can pair through _______ bonding between their __________ bases.

A

hydrogen
nitrogenous

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6
Q

DNA: Their complementary ___________ sequences give rise to structural complementarity.

A

nucleotide

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7
Q

Formation by e- pair sharing makes ___, ___, ___, and ___ appropriate for the support of life.

A

H, C, N, O

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8
Q

H, O, C and N make up ___% of atoms in the human body

A

99

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9
Q

What property unites H, O, C and N and renders these atoms so appropriate to the chemistry of life?

A

Their ability to form covalent bonds by electron-pair sharing

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10
Q

Hydrogen, Oxygen, Carbon, and Nitrogen percentage in the human body

A

Hydrogen: 63%
Oxygen: 25.5%
Carbon: 9.5%
Nitrogen: 1.4%

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11
Q

Units for Building Complex Structures

A

Simple Molecules

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12
Q

4 Simple molecules

A

o Metabolites
o Macromolecules and Membranes
o Organelles
o The Unit of Life is the Cell

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13
Q

Structural Organization of Complex Biomolecules

A
  1. inorganic precursors
  2. metabolites
  3. building blocks
  4. macromolecules
  5. supramolecular complexes
  6. organelles
  7. the cell
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14
Q

T/F:
Macromolecules and their building blocks have a “sense” or directionality and are informational.

A

True

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15
Q

Biomolecules have characteristic ______-dimensional architecture

A

three

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16
Q

______ forces maintain biological structure and determine biomolecular interactions

A

Weak

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17
Q

What builds proteins?

A

amino acids

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18
Q

What builds polysaccharides?

A

sugars

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19
Q

T/F:
Weak forces profoundly influence the structures and behavior of SELECTED biological molecules.

A

False
all biological molecules

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20
Q

Nucleic acids are polymers of?

A

nucleotides

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21
Q

hold atoms together so that molecules are formed

A

covalent bonds

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22
Q

T/F:
Weak forces create interactions that are CONSISTENT under physiological conditions

A

False;
constantly forming and breaking

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23
Q

Energies of weak forces range from _____ to ______

A

0.4 to 30 kJ/mol

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24
Q

Weak forces include?

A
  • van der Waals interactions
  • Hydrogen bonds
  • Ionic interactions
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25
mediated by weak chemical forces
Biomolecular recognition
26
Give the values of strength in kJ/mol * Van der Waals Interactions: * Hydrogen Bonds: * Ionic Interactions: * Hydrophobic Interactions:
* Van der Waals Interactions: 0.4-4.0 kJ/mol * Hydrogen Bonds: 12-30 kJ/mol * Ionic Interactions: 20 kJ/mol * Hydrophobic Interactions: <40 kJ/mol
27
T/F: Weak forces RESTRICT organisms to a narrow range of environmental conditions.
True
28
principle that guides the biomolecular interactions that characterize the living state
Molecular Recognition Through Structural Complementarity
29
A type of interaction where strength depends on the relative size of the atoms or molecules and the distance between them
Van der Waals interactions
30
A type of bond where the relative strength is proportional to the polarity of the bond donor and bond acceptor
Hydrogen bond
31
T/F: In van der waals interactions, the size factor determines the area of contact between two molecules: the greater the area, the WEAKER the interaction.
False stronger
32
T/F: More polar atoms form stronger H bonds.
True
33
Type of interaction where strength also depends on the relative polarity of the interacting charged species
ionic interaction
34
T/F: Ionic interactions cannot be H bonds.
False Some ionic interactions are also H bonds: --NH3+ ... -OOC-
35
Type of interaction where force is a complex phenomenon determined by a the degree to which the structure of water is disordered as discrete molecules or molecular regions coalesce
hydrophobic interactions
36
T/F: Ionic bonds contribute to the stability of proteins.
True
37
Important to biomolecular interactions
Van der Waals Forces
38
Enhanced in molecules that are structurally complementary
Van der Waals Forces
39
surface protuberance on lysozyme recognized by the antigen-binding site of an antibody against lysozyme
Gin121
40
Process of life have durations ranging over ___ orders of magnitude
33
41
Plasma membrane of prokaryotic cells
single plasma membrane
42
Do prokaryotic cells contain nucleus?
No
43
Which is larger: prokaryotic cell or eukaryotic cell?
eukaryotic cell (103-104 times larger)
44
Who designed a thousand DNA segments and combined them to make a synthetic version of the genome of Mycobacterium mycoides?
J. Craig Venter and colleagues
45
J. Craig Venter and colleagues designed a thousand DNA segments and combined them to make a synthetic version of the genome of?
Mycobacterium mycoides
46
What did mycobacterium mycoides produce?
self-replicating cells
47
What do self-replicating cells from mycobacterium mycoides represent?
the first artificial living organisms
48
a member of the coliform group of bacteria that colonize the intestinal tract of humans
escherichia coli
49
What structures can be found in prokaryotic cells?
cell wall cell membrane nuclear area or nucleoid ribosomes storage granules cytosol
50
What structures can be found in animal cells?
extracellular matrix cell or plasma membrane nucleus endoplasmic reticulum and ribosomes golgi apparatus mitochondria lysosomes peroxisomes cytoskeleton
51
What structures can be found in plant cells?
cell wall cell membrane nucleus endoplasmic reticulum gogli apparatus ribosomes lysosomes peroxisomes cytoskeleton chloroplasts mitochondria vacuole
52
cell wall (prokaryotic cell) molecular composition: function:
peptidoglycan; mechanical support, protection
53
cell membrane molecular composition: function:
lipids and proteins; permeable barrier that controls the entry of substances into the cell
54
nuclear area or nucleoid molecular composition: function:
single, tightly coiled, circular DNA molecule; provides operating instructions for the cell
55
ribosomes molecular composition: function:
composed of small and large subunits; site of protein synthesis
56
storage granules molecular composition: function:
storage forms of polymerized metabolites; metabolic fuel
57
cytosol molecular composition: function:
gelatinous compartment; site of intermediary metabolism
58
extracellular matrix molecular composition: function:
complex carbohydrates, proteins, and lipids; cell-to-cell recognition, communication, cell adhesion, protective outer layer
59
nucleus molecular composition: function:
has a double membrane and nuclear envelope; repository of genetic information encoded in DNA
60
rough endoplasmic reticulum molecular composition: function:
flattened sacs of internal membrane with ribosomes; produce proteins
61
smooth endoplasmic reticulum molecular composition: function:
flattened sacs of internal membrane; synthesizes lipids, phospholipids, and steroids
62
golgi apparatus molecular composition: function:
flattened membrane-bound vesicles; packaging and processing of macromolecules
63
mitochondria molecular composition: function:
surrounded by two membranes; site of ATP synthesis
64
lysosomes molecular composition: function:
contain hydrolytic enzymes; intracellular digestion of materials entering the cell
65
peroxisomes molecular composition: function:
contain oxidative enzymes; oxidize certain nutrients
66
cytoskeleton molecular composition: function:
protein filaments (actin); shape of the cell, movement
67
cell wall (plant cell) molecular composition: function:
cellulose fibers in a polysaccharide/ protein matrix; protection against osmotic or mechanical rupture
68
chloroplasts molecular composition: function:
double-membrane envelope, with stroma and lumen; site of photosynthesis
69
vacuole molecular composition: function:
enclosed by tonoplast (single membrane); transport and storage of nutrients and cellular waste products
70
genetic elements enclosed in a protein coat
viruses
71
Viruses are genetic elements enclosed in a?
protein coat
72
T/F: Viruses are free-living organisms and can reproduce in other structures.
False; not free-living, can reproduce only within cells
73
Viruses show an almost absolute __________ for their particular host cells, infecting and multiplying only within those cells.
specificity