Unit 1 BHS: Cell Biology Flashcards
Structural organisation of human as an organism (system - organ - tissue - cells)
11 systems
many organs
4 primary tissues
cells in ECM
Cell Theory
- All living things are composed of one or more cells.
- Cells = structural & functional unit of all living organisms.
- Cells = fundamental units of life
2 main classes of cells
- Eukaryotes - contain nucleus (cells of animals, plants, fungi)
- Prokaryotes - no nucleus (cells of bacteria)
3 main components of a cell
- Nucleus
- Cytoplasm
- Plasma membrane
What is a nucleus and outline the structures associated with it
nucleus contains the genetic information of the organism. Play NB roles in heredity, gene expression, and cell division.
ASSOCIATED STRUCTURES:
1. Nuclear membrane - double-layered membrane that surrounds nucleus. Nuclear pores are locations where the two layers fuse, these pores serve to traffic RNAs and proteins in and out of the nucleus (NOT DNA)
- Chromatin - DNA bound by histone proteins. There are two types of chromatin. heterochromatin: condensed, inactive DNA; euchromatin: active DNA, relatively extended.
Chromatin condenses to form chromosomes during cell division.
- Nucleolus - consists largely of RNA and protein, function = manufacture ribosomes. Prominent in protein-producing cells.
Cytoplasm: components
- material between cell membrane and nuclear membrane
- includes cytosol and organelles
CYTOSOL: protein fibres called cytoskeletons are arranged in a complex latticework surrounding organelles
ORGANELLES: membrane-bound structures that perform a specific function.
(centrioles, ER, Peroxisomes, Golgi apparatus, lysosomes, mitochondria, ribosomes, vacuoles)
Cytoskeleton: structure, function, three types
- extensive network of long, thin protein filaments and tubules.
- Fn: maintain the shape of cell, anchoring organelles, moving the cell and controlling internal environment of structures.
THREE TYPES OF CYTOSKELETON
- Actin: thinnest filaments. Contractile. Aid motility
- Microtubules: thickest filaments. Important for dividing cells.
- Intermediate filaments: mechanical strengthening
Vacuoles: function
membrane-bound sacs for:
- storage
- digestion
- waste removal
- isolation of harmful material
Centrioles: structure, location, function
- paired, cylindrical. Located near nucleus.
- each centriole = 9 bundles of microtubule arranged in a ring
- 1 bundle = 3 filaments
- lie at right angles to each other
- involved in cellular division. Guide the alignment of the chromosomes as they separate during mitosis.
Ribosomes: structure, function & two types
- consists of 2 subunits: small vs. large
- each subunit consists of RNA and protein
- fn: Translation. (Translation of mRNA into protein)
TWO TYPES OF RIBOSOMES
- Mobile type: injects proteins directly into cytoplasm
- Stationary type: embedded in rough ER
Endoplasmic reticulum (ER): two types, functions, locations, structures
- tubular network fused to nuclear membrane and zigzags through cytoplasm.
TWO TYPES OF ER:
1. Smooth: lacks ribosomes. Furthest from nucleus, involved in storage, transport and lipid synthesis.
!!Prominent in lipid/steroid secreting cells!!
- Rough: ribosomes attached. Connect to nuclear membrane and smooth ER. Protein synthesis.
!!Prominent in cells synthesising protein!!
Golgi complex: structure and function
- stacks of membrane-bound sacs. Consists of a cis face and a trans face. Cis face closer to ER
- fn: modifies proteins and lipids that have been made in ER. 1) prepares them for export outside the cell or 2) transport to cellular compartments in the cell
Lysosomes: function, origin
- contain hydrolytic enzymes
- fn: digest/destroy invading matter and unwanted cellular material
DERIVED FROM GOLGI.
- primary lysosome: empty
- secondary lysosome: engulfed material to destroy
!!Abundant in immune cells (disease fighting) e.g. leukocytes!!
PATHOLOGY: Tay-Sachs
Peroxisome: function, enzymes
- small, spherical
- fn: lipid metabolism & management of waste products
ENZYMES:
1) oxidases: catabolic (H2O2) - breakdown of toxic substances e.g. phenols and alcohol
2) catalases: regulate H2O2 concentration
!!prominent in liver and kidney!!
Mitochondria - function, structure, mode of inheritance
- energy production
- double-layered membrane = inner membrane forms folds called cristae -> site of energy production
- contain enzyme system to make ATP
- possesses own RNA and DNA
- maternal inheritance
PATHOLOGY: Leber’s hereditary optic neuropathy (blindness)