Unit 1 Flashcards
idiosyncratic effect
•an uncommon, unexpected, or individual drug response thought to result from a genetic predisposition
toxic effect
•a seriously adverse drug rxn caused by excessive dosing
synergistic effect
•an increase in the effects of any or all of two or more drugs taken together
adverse rxn/effect
- any noxious, unintended, and undesired result of taking a drug in appropriate doses
- NOT a side effect b/c side effects are harmless
drug tolerance
•pt requires increased dosage of medication to achieve intended therapeutic benefit
addictive behavior
•pt continues to take medication despite harmful effects
physical drug dependence
•pt exhibits signs of withdrawal when a mediation is discontinued
drug reliance
•pt develops an intense craving for a drug
generic (nonproprietary) drug name
- noncommercial name assigned to a drug by US adopted names
- each drug has only ONE
- syllables at end indicate class
- Ex: acetaminophen
enteral medication administration
•via GI tract
sublingual medication administration
•via mucosa under tongue
transdermal medication administration
•via skin patch
parenteral medication administration
•via injection
preoperative period
- begins when pt scheduled for surgery
- ends at time of transfer to OR
- time for pt and family teaching
inpatient surgical procedures
- emergent- immediately
- urgent- put on schedule ASAP
- elective
outpatient (ambulatory) surgery
- most often elective
- not acute
- Ex: cataract removal, hernia repair
preoperative assessment
- physical, emotional, and psychosocial status prior to surgery
- Hx, meds, labs, allergies, anxiety, HTT
- blood donations
- discharge planning
nurse role in informed consent
- clarify info, but NOT give new info
- witness pt signing form (must be done before pre-op meds)
- ensure correct site is selected
preoperative teaching
•pain control •breathing/spirometer •ROM •anti-embolism •diet •invasive devices •anti-anxiety *demonstrate and then have pt state understanding and demonstrate
high RBC/hematocrit indicates…
- high RBC production
* dehydration b/c blood is very concentrated
venous thrombo-embolism (VTE)
- embolisms formed in venous blood due to venous stasis/pooling (legs/heart)
- can develop DVT or pulmonary embolus
pts most at risk fro VTE
- immobile
- obese
- > 40 y/o
- hx of cancer
- spinal injury
- Hx of VTE, PE, varicose veins, edema
- oral contraceptives
- smoking
- hx decreased cardiac output (pooling blood in heart)
- hip fracture, total hip/knee surgery
NPO prior to surgery
•6-8 hrs before general anesthesia
•3-4 hrs before local anesthesia
•goal is to prevent aspiration
*consult physician regarding regularly scheduled meds
hypothermia during surgery
•increases chance of surgical/wound infection
•alters metabolism of meds
*why need to give pt warm blanket
prophylactic antimicrobials
- given 1 hr prior to incision
* given to prevent surgical site infection
biggest concern of sedatives/opioids
•respiratory depression
Intraoperative care
•while pt is in surgery
holding area nurse
•monitors pt before surgery
circulating nurse
- coordinates all activities in OR
- sets up/checks equipment
- preps pt
- documents care/events
- counts sponges/instruments
scrub nurse
- sets up sterile field
- drapes pt
- hands sterile instruments
- supplies surgeon
- maintains sponge/equipment count
equipment/sponge counts
•performed 4 times
- ) before
- ) during
- ) beginning of 1st closure
- ) before final closure
anesthesia
- induced state of partial or fatal loss of sensation
- with or w/o loss of consciousness
- used to block nerve impulse, suppress reflex, relax muscle, achieve controlled unconsciousness
general anesthesia
- reversible loss of consciousness induced by inhibiting neuronal impulses in CNS
- causes analgesia, amnesia, unconsciousness, and loss of reflexes/tone
- used for major surgery or requiring major muscle rlx
inhaled anesthetics
- volatile gases/liquids dissolved in O2
- most controllable method
- few side effect
- limited muscle rlxn
IV anesthetics
- rapid
- contraindicated w/ kidney/liver dz
- increases resp. depression
- Ex: propofol
balanced anesthesia
- combo of IV drugs and inhaled agents
* goal is sedation, amnesia, analgesia, immobilization
adjuncts to general anesthetic agents
- hypnotics
- opioid analgesics
- neuromuscular blocking agents (need other meds on board b/c will paralyze conscious pt)
malignant hyperthermia
- acute, life-threatening complication of drugs (anesthetics)
- begins when skeletal muscle exposed to agent
- causes increased Ca2+ levels in muscles
- causes increased muscle metabolism
- causes increase in serum Ca2+ and K+
- leads to metabolic acidosis (not enough O2 to cells), cardiac dysrhythmias, high body temp
- can occur during any point of anesthetic administration, maintenance, or recovery
- may be genetic
clinical manifestation malignant hyperthermia
- tachycardia/pnea
- elevated body temp
- muscle rigidity
- skin mottling
- cyanosis
- myobloinuria (muscle protein in urine)
- rise in tidal CO2 and decrease in O2 sat
local anesthesia
- loss of sensation w/o loss of consciousness
- motor fxn may/may not be affected
- topical, local infiltration, or regional
- often supplemented w/ sedative, opioid analgesics, hypnotics
- risk for aspiration low b/c cough/gag reflex intact
regional anesthesia
- blocks multiple peripheral nerves in specific body region
- field
- nerve
- spinal
- epidural
field anesthesia
•series of injections around operative field
nerve anesthesia
•injection into or around one nerve or group of nerves
spinal anesthesia
- injection into CSF in subarachnoid space
* abdominal, pelvic, hip, knee surgeries
epidural anesthesia
- injection into epidural space
* anorectal, vaginal, perinea, hip, lower extremity surgeries
moderate (conscious) sedation
- IV delivery of sedative, hypnotic, opioid drugs to reduce LOC for minor procedures w/o pt having discomfort
- pt responds to verbal stimuli, retains reflexes, and is easily aroused
- pt maintains airway
- often used for burn debridement
addressing malignant hyperthermia
- stop procedure and remove from anesthesia
- bag pt
- give IV Dantrolene muscle relaxant given for malignant hyperthermia
- may also have to give sodium bicarbonate
- lavage organs with cold water (addresses high temp)
which factor is of greatest concern for risk of infection during surgery
•diabetes mellitus
postoperative period
•begins w/ completion of surgery and transfer to PACU, ambulatory care unit, or ICU
PACU recovery room
- ongoing evaluation/stabilization of pt to anticipate, prevent, and manage complications after surgery
- priorities include resp. and circulation (bleeding)
circulating nurse AND anesthesia providers’ role post-op
- transfer pt to PACU
* give PACU nurses verbal hand-off reports
function return after surgery
- touch
- movement
- pain
- warmth
- cold
readiness for discharge from PACU
- pt goes home or post surgical unit
- pt must take fluids orally and safely ambulate to bathroom w/ assistance
- pt must have aldrete score of 8-10, stable VS, no bleeding, return of reflexes, moderate drainage, and UOP of at least 30 ml/hr
- auscultation of bowel sounds
aldrete score
- used to monitor recovery from anesthesia
- scores from 0-2 in all areas
- greater score -> better
5 areas to determine aldrete score
- ) activity
- ) consciousness
- ) respiration
- ) O2 saturation
- ) circulation
emergy care of pt w/ opioid overdose
- administer Narcan 1-2 mg IV every 2-3 min
- repeat until 10 mg reached if needed
- maintain open airway
- O2 if hypoxia present
- suction if vomiting
- don’t leave pt alone
- monitor every 10-15 min until stable
post-operative complications
- airway obstruction
- hypoxia
- hypovolemic schock (massive loss circulating blood)
- paralytic ileus
- wound dehiscence or evisceration
- DVT
hypoxemia
- poor tissue perfusion
- highest incidence 2nd post-op day
- tx w/ airway maintenance, semi-fowlers, O2 therapy
major components of fluid in body
1.) intracellular (ICF)- ⅔
2.) extracellular (ECF)- ⅓
•ECF includes intravascular and interstitial
•fluid can move b/t
electrolytes
- minerals (salts) present in body fluids
- regulate fluid balance and hormone production
- strengthen skeletal structures
- serve as catalysts for nerve responses, muscle ctx, and metabolism
fluid volume deficit (FVD)
- fluid imbalance
- hypovolemia and dehydration
- tachy
hypovolemia (isotonic FVD)
- body loses fluid and electrolytes from ECF
- intravascular fluid lost
- can lead to hypovolemic shock
- thready pulse b/c pumping blood faster
dehydration (osmolar FVD)
•water, but not electrolyte loss
compensatory mechanisms for FVD
- SNS responses of thirst
- ADH release
- aldosterone release
hemoconcentration
•decrease in the volume of plasma in relation to # of RBCs
•increase in concentration of circulating RBCs
•increases in Hct, Hgb, electrolytes, and urine specific gravity
*expected in endurance athletes
FVD causes
- GI losses (vomit, diarrhea, etc)
- diaphoresis
- renal loses
- hemorrhage
- third spacing- retaining fluid in interstitial spaces (ascites, burns)
- altered fluid intake
- hyperventilation
- diabetes ketoacidosis
- fever
FVD subjective
- dizzy- poor perfusion to brain
- weak
- lethargic
- fatigue
FVD objective
- hyperthermia
- syncope
- tachycardia/pnea- compensate to maintain CO
- thready pulse- vasoconstriction in periphery
- hypotension
- oliguria
- confusion
- diminished cap. refill
FVD laboratory
- increased Hct
- increased serum osmolarity
- increased urine specific gravity and osmolarity
- hypernaturia
hypernatremia
•increased serum sodium or excessive water concentration in relation to sodium
FVD tx
- IV fluid replacement
* crystalloids or collide, depending on how fluid was lost
is it better to replace fluids via PO or IV
- PO b/c normal body fxn
* If urgent, give IV b/c it’s fastest
crystalloids
•lactated ringers •normal saline •isotonic •used for dehydration situation *best IV fluid replacement
colloids
- blood transfusions
- larger molecules that help draw fluid into intravascular space
- most often used for hemorrhage, massive wound, etc
hypotensive postion
- on back w/ legs elevated
* trendelenburg if crisis
acceptable UOP
•greater than 30 mL/hr
hypovolumetric shock
- decreased oxygen to organ/pressure to organ
- complication of FVD
- tx w/ O2, fluids, vasoconstrictors (increase central flow first)
fluid volume excess (FVE)
- fluid imbalance
- hypervolemia or over-hydration
- tachy
hypervolemia (isotonic FVE)
- both water and sodium are retained in high proportions
- blood volume increases
- severe cases can lead to pulmonary edema, heart failure, and hyponatremia
- bounding pulse
over hydration (osmolar FVE)
•more water than electrolytes gained
compensatory mechanism for FVE
- release of natriuretic peptides -> increased excretion Na+/H2O from kidneys
- decreased release of aldosterone
FVE risk factors
- heart failure, increased glucocorticosteroids (-> fld retention)
- kidney failure
- fluid shifts (burns, IV fluid admin)
- excessive Na+ intake
- excessive fluid intake w/o electrolytes (athletes)
FVE subjective
- confusion
- SOB
- lethargy
- muscle weakness
FVE objective
- tachycardia/pnea
- bounding pulse
- hypertension
- weight gain
- crackles
- edema
- JVD
FVE labs
- decreased Hct, serum osmolarity
- decreased BUN, creatinine, electrolytes
- respiratory alkalosis (dec. CO2/inc. pH)
- chest x-ray showing pulm. congestion
FVE tx
- limit fluid/Na+ intake
- admin diuretics
- admin O2
hypotonic solution
- osmolarity of less than 270 mOsm/L
- fluid into cells (lyse)
- 0.5% NS
hypertonic ECF
- osmolarity of greater than 300 mOsm/L
- fluid out of cells (crenation)
- 1.5% NS or 3% NS
isotonic ECF
- osmolarity of 270-300 mOsm/L
* 0.9% NS
aldosterone
•excreted by the cortex of the adrenal gland in response to low Na+ levels
•prevents sodium and water loss
*retain fluid
anti-diuretic hormone (ADH)
•Produced in the posterior pituitary
•acts on kidneys to make kidneys reabsorb more water so that the body retains more fluid
*retain fluid
natriuretic peptides (NPs)
•released in response to barorecptors in the heart or vascular system detecting increased blood volume
*LOSE fluid
renin angiotension system
- in response to low BP, blood volume, blood O2, and blood osmolarity kidneys excrete renin
- renin catalyzes formation of angiotension I, which is converted to angiotension II (active form) by ACE
angiotension II
- vasoconstrictor
- causes nephrons to contract, decreasing UOP
- causes kidneys to release aldosterone
an ACE inhibitor would be classified as…
- diuretic
- lowers BP b/c blocks production of angiotension II
- commonly used for mild HTN
sodium
•major electrolyte found in ECF (intravascular), body fluids, and secretions
•essential for maintenance of acid-base and fluid balance, transport mechanisms, and nerve conduction
*imbalances cause NEURO problems
expected serum sodium levels
•135-145 mEq/L
hyponatremia
•serum Na+ level less than 136 mEq/L
•net gain of H2O or loss of Na-rich fluids
•delays/slows depolarization of membranes
•H2O moves from ECF to ICF (cerebral edema)
•Na+ loss via GI, renal, skin
•also caused by increased ECF H2O
*dehydrated OR over hydrated
hyponatremia s/s
- serum Na+ level less than 136 mEq/L (BMP)
- serum osmolarity less than 280 mOsm/kg
- heart failure