UNIT 1 Flashcards
130 BC: recorded that individuals who had previously contracted
plague recovered. He recognized the “immune” status of those
individuals.
THUCYDIDES
1000: _____ practiced a form of immunization by inhaling dried powders
derived from smallpox lesions
● Concept of Variolation
Chinese
15th century: _______ powdered smallpox crust were inserted with a pin on the skin
In England,
1717: Observed the inoculation practice of Chinese against
smallpox and brought it to England “The smallpox, so fatal, and so general against us, is
here entirely harmless,
lady mary worthy montague
1798: Demonstrated cross
immunity; Smallpox
vaccination
edward jenner
1862: phagocytosis
haeckel
Live attenuated, chicken
cholera and anthrax vaccine
louis pasteur
1862: (Father of
Immunology and
Modern
Microbiology)
Louis pasteur
First report of live “attenuatedˮ vaccine for rabies
Proved the Germ Theory of Disease
Invented the process of Pasteurization
louis pasteur
1883-1905: Cellular theory of immunity
through phagocytosis
elie metchnikoff
1890: Humoral theory of immunity
proposed; serum
emil von behring, kitasato
1891: Demonstration of cutaneous
(delayed-type)
hypersensitivity
robert koch
Accidentally demonstrated
delayed hypersensitivity
reaction
tuberculin test
false positive
for TB infection because of
presence of antigen due to
previous infection
tuberculin test
better than
tuberculin test
○ Analyzed in CURRENT ACUTE
PHASE of TB infection.
IGRA TEST : interferon gamma release
1900: antibody formation theory
ehrlich
1902: Immediate-hypersensitivity
Anaphylaxis (allergy)
● Also known as Type I
hypersensitivity
● Immediate response and due
to IgE (antibody that triggers
allergic reaction)
portier, richet
1903: Arthus reaction of
intermediate hypersensitivity
● Type III hypersensitivity due
to immune reaction
nicolas maurice arthus
1938: Hypothesis of antigen- antibody
binding
marrack
1944: Hypothesis of allograft
rejection
● Described immunologic
processes in transplantation
peter medawar
1949: Development of polio vaccine
JTF
John enders
Thomas weller
Frederick robbins
1950s: polio vaccine din but This is said to be better because you have an option to choose
how to administer the vaccine
SALK - IPV
SABIN - OPV
1951: Vaccine against yellow fever
REED
1953: Coined and was behind the principle of
immunoelectrophoresis
GRABAR WILLIAMS
1953: Graft-versus- Host reaction
dick w. van bekkum
1957: Clonal selection theory
BURNET
1957: Interferon (viral interference)
alick isaacs and jean lindemann
1958- 1962: HUMAN LEUKOCYTE ANTIGEN
JEAN DAUSSET
1964-1968: T cell and B cell cooperation in
immune cooperation
henry claman
1972: Identification of antibody
molecule
The Y-structure of antibody
EDELMAN AND PORTER
1975: First monoclonal antibodies
kohler and milstein
1977: RIA
rosalyn yalow
1978-1987: Awarded Nobel Prize for genetic principle of
antibody diversity
susumo tonegawa
Awarded Nobel Prize for their contribution MHC
gene
SCB
George snell, jean dausset, baruj benacerraf
1985-1987: Identification of genes for T cell
receptor
james p. allison
1986: Monoclonal hepatitis B vaccine
pablo DT valenzuela
1986: Th1 versus Th2 model of T
helper cell function
mossman
1996-1998: identification toll like receptor
jules hoffman and bruce beutler
1997: Discussed their approaches to develop “better
vaccines.
ˮ They were intrigued by the ssmRNA
use in coding the blueprint DNA to make proteins
that can function in the body
drew weissman
katalin karikó
2001: FOXP3, the geen directing regulatory t-cell development
ramsdell and colleagues
2005: Development of human
papilloma virus HPV vaccine
IAN FRANZER
2008: Awarded the Nobel Prize for their discovery of HIV
Harald zur hausen
françoise barre sinoussi
luc montagnier
Jan 2020: BioNTech proponents.
● Focused first on cancer immunotherapies until
they used the model mRNA COVID10 vaccines,
shown positive results in all important 3 clinical
trials.
ugur sahir
ozlem tureci
