Uncommon Blood Groups Prt.1 Flashcards
DIEGO
Chromosome
Gene
• CHROMOSOME 17
• SLC4A1 gene
DIEGO
Antibodies
• IgG, sometimes IgM
•Causes HTR and HDFN
DIEGO
• ANTIGENS
•_____ antigens
• High and low prevalence antigens
• Carried on band___
•____ exchanger
• Carries ABH and I antigens
22
3
Anion
DIEGO
Expression???
Resistant to??? (4)
•Expressed upon birth
• Resistant to ficin, papain, DTT, glycine-acid EDTA
• = first discovered maker of anti-yt
Cartwright
YT
• CHROMOSOME___
•____ gene
7
AChE
YT
• ANTIBODIES
• IgG (1 and 4)
• May cause HTR
YT
• ______= common phenotype
•____ - high incidence
•____ - not found in Japanese - (Israelis)
Yt (a+b-)
Yta
Ytb-low
• ANTIGENS
• High and low prevalence antigens
• Developed upon birth
• Negative in PNH cells
YT
YT
• Sensitive to (3)
• Resistant to (1)
ficin, papain, and DTT
glycine-acid EDTA
Xg
•____chromosomes
•____ and _____genes
X
XG and MIC2
Xg
• Antibodies
•____, some are naturally occuring
• Not implicated in HTR and
HDFN
IgG
Xg
g for ‘_______’, ‘, the location
where the person was treated
Grand Rapids
Xg
Antigens
• (2)
•____% in women and____% in males
Xgª and CD99
89
66
Xg
•Sensitive to (2)
• Resistant to___
ficin and papain
DTT
Scianna System
CHROMOSOME___
• ______ gene- RBC ahesion CHON
1
ERMAP gene (Erythroid
Membrane Associated Protein)
Scianna
• ANTIBODIES
•____
• May cause mild HTR and mild HDFN
IgG
Scianna system
ANTIGENS
• _____antigens
• High (5) and low prevalence (2) Ags
7
SC1, 3, 5,6,7
SC2, SC4
Scianna
• Carried on_____
• Expressed on____
• Resistant to (2)
• Slightly weakened by ____
ERMAP
cord RBCS
ficin and papain
DTT
Dombrock
CHROMOSOME____
•______ gene (regulation of cellular protein function)]
12
ART4 gene [monoART4 = mono-ADP-ribosyltransferase 4
Dombrock
• ANTIBODIES
•___ rarely ____
• Causes____ but not ____
IgG, rarely IgM
delayed HTR but not HDFN
Dombrock
ANTIGENS
• High and low prevalence Ags •Carried on mono-ART4
•Expressed upon birth: (-) in PNH
cells
• Resistant to (3)
• Sensitive to (1)
ficin, papain, glycine-acid EDTA
DTT
Dombrock
• High Prevalence Ags:
(2) - (poor immunogens)
____ - (highly immunogenic) and
(4)
Doa and Dob
Gya
Hy; Joa; DOYA and DOMR
Dombrock
(3)- high incidence antigens
• Gya, Hy, Joa
Colton
• CHROMOSOME____
•____ gene
7
AQP1
Colton
• ANTIBODIES
•___ rarely ___
• Causes_____ and ____
IgG, rarely IgM
HTR and HDFN
Colton
ANTIGENS
•____ antigens
• High (___) and low prevelance (____) Ags
• Carried on____
• Integral protein
• Expressed upon birth
• Resistant to (4)
4
Coa; Cob
aquaporin 1
ficin, papain, DTT, chloroquine
Colton
Antigens
•______ present in all RBCs except with the Co(a-b-) phenotype
•_____ present with the Co(a-b-) phenotype
Co3
Co4
Landsteiner-Wiener system
CHROMOSOME___
•______ gene [intracellular adhesion molecule]
19
ICAM4
Landsteiner-Wiener System
• ANTIBODIES
• Probably___
• HTR/HDFN???
IgM
DO NOT CAUSE HTR and HDFN
Landsteiner-Wiener
ANTIGENS
•___ antigens
• High (2) prevalence Ags
• low prevalence (1) Ags
• Carried on_____
• Null phenotype:____
3
Lwa, Lwab
LWb
ICAM-4
LW(a-b-)
Landsteiner-Wiener
• Destroyed by____
• Resistant to ____ and ____
DTT
enzymes and glycine-acid EDTA
• Reacts to all cord cells regardless of o type, one way to differentiate it with anti-Rh
Landsteiner-Wiener
Chido/ Rodger
• CHROMOSOME___
• ______ and _____ gene
6
C4A (Rg) and C4B gene (Ch)
Chido/ Rodgers
• ANTIBODIES
•____, neutralized by____
• Clinically significant/ insignificant???
IgG
plasma
insignificant
Chido/ Rodgers
ANTIGENS
•___ antigens
• High (8) and low prevalence (1) Ags
• Carried what genes???
9
CH1-CH6; RG1, RG2; WH
C4A (Rg);
C4B (Ch)
Chido/ Rodgers
• Destroyed by (2)
• Resistant to (3)
ficin, papain
DTT, glycine-acid EDTA
Gerbich
CHROMOSOME___
•___ gene
2
GYPC
Gerbich
Antigens
• 6 (high freq) -
• 5 (low freq) -
Ge2, Ge3, Ge4, GEPL, GEAT and GEt1
Wb, Lsa, Ana, Dha, GET1
Gerbich
Antigens
• Expressed on ____ and ____
• Expressed at birth
• Decreased in_____
• Resistant to (2)
GPC and GPD
hereditary elliptocytosis (loss of protein 4.1)
Decreased in hereditary elliptocytosis (loss of protein 4.1)
Gerbich
Gerbich
• NULL/WEAK PHENOTYPES (3)
• Yus (Ge-2, 3,4)
• Gerbich (Ge-2, -3, 4)
• Leach (Ge-2, -3, -4)
Gerbich
• ANTIBODIES
•_____ (most common)
• Mostly IgG, rarely IgM (RT, enhanced by____)
• Usually clinically significant
• Mrs. Gerbich - first ab producer
Anti-Ge2
AHG
Cromer
•______ - black prenatal patient
• The ab reacted to all other
RBCs except hers and 2 siblings
Mrs. Cromer
Cromer
•________
- complement regulatory protein
(CD55 gene)
• involved in the regulation of complement activation by accelerating the decay of C3 and
C5 convertase
• integral intrinsic membrane glycoprotein that is anchored by
GPI
DAF (Decay Accelerating Factor)
Cromer
• CHROMOSOME ____
•____ gene
1
CD55
Cromer
• ANTIGENS
•____ antigens
• 15 (HF) - Tca and Dra;
• 3 (LF) - Tcb and Tcc
• Carried in____
• Expressed in_____ tissues
19
DAF
placental
• Carried in DAF
• Expressed in placental tissues
Cromer
Antigens
• found in membranes of RBCS, plts, granulocytes, lymphocytes, placenta, and lower soluble quantities in plasma and urine
• Expressed in cord cells
• Negative in PNH cells
Cromer
Cromer
• Resistant to treatment with (3)
• Sensitive to_____
• Weakened, not destroyed by (2)
ficin and papain, glycine-acid EDTA
chymotrypsin
AET and DTT
Cromer
•NULL/WEAK PHENOTYPES
•______ - Cromer null
• ______phenotype - Weak Cromer expression
Inab
Dr (a-)
Cromer
ANTIBODIES
• (2)
• Implicated in HTRs but does not cause HDFN
• (1)
Anti-Cra and Anti-Tca (IgG)
Anti-IFC
Cromer
Antibody
•______ - has been associated with mild transfusion reactions but there are cases documented of Cra- transfused with Cra+ cells but no reaction
Anti-Cra
