Lewis Part 2 Flashcards
CANNOT CAUSE______
Le antibodies are____ (cannot cross through placenta)
Le antigens are not fully developed at birth
It will only be develop____ after birth
HDFN
IgM
10 days
• CONSIDERED INSIGNIFICANT IN BLOOD TRANSFUSION
_______can be easily neutralized by Le antigen in plasma
IMPORTANT: detects @ 37°C and Coombs phase (+)
Le antibody
can readily dissociate from RBCS (not permanent on RBC)
Le antigen
OTHER LEWIS ANTIGENS
Le Se^w→
“W” - means weak
Le(a+b+)
analogous to Le^a
analogous to Le^b
• Le^c
• Le^d
isomer of Le^a
isomer of Le^b
• Le^x
• Le^y
are molecules with the same formula but different structures.
Isomers
compounds have different structures but similar properties because of similar functional groups.
Analogous
SECRETION
Le(a+b-)
Nonsecretors
Nonsecretor b/c its structure is paragloboside w/ no glucose attached
Le^c
SECRETION
Le(a-b+)
Secretors
Secretor b/c it is similar to H antigen
Led
Le^x
Secretion
Le^a
Le^y
Secretion
Le^b
If you have Le^c in secretions→ in RBC…
you’re nonsecretor in RBC
Le(a-b-)
If you have Le^d in secretions→in RBC…
you’re secretor in RBC Le(a-b-)
• If you have Le^a in secretions→ possibly, when adsorbed by RBC produces…
Le^x
• If you have Le^b in secretions→possibly, when adsorbed by RBC produces…
Le^y
Lewis null and/or non secretor phenotype has also been linked w/ a higher incidence of recurrent…
Candida vaginitis & UTI
Nonsecretor phenotype protects against…
Norovirus infection
binds to H, Le^b & Le^y antigens
Helicobacter pylori
- SECRETIONS
•_________
• CANNOT adsorb onto RBC
membranes
GLYCOPROTEINS
- PLASMA
•________ (mostly produced in GIT)
CAN adsorb onto RBC
membranes
GLYCOLIPIDS
LEWIS ANTIGEN
If the Le gene is inherited, ____ substance is produced
Le and Se gene must be inherited to convert H to ____
Le^a
Le^b
Le se H →
Le Se H →
le se H →
le Se H →
Le (a+b-)
Le (a-b+)
Le (a-b-) → H antigen
Le (a-b-) → H antigen
“w” Stands for weak
Formation of non-functional or partially functional transferase
Le^w
Le
Detectable in the RBCs approximately_____ after birth
Lewis glycolipids are not detectable in plasma until _____after birth
10 days
10 days
are detectable in saliva at birth
Le^a & Le^b glycoproteins
Le - se
Newborn: Le (a-b-)
~after 10 days
Le (a+b-)
Le - Se
Newborn: Le (a-b-)
~after 10 days
_______
Le (a+b+)
~after 6 years
_______
Le (a+b-)
Le (a-b+)
le - se
all throughout (amorph)
Le gene can easily be neutralized
Le (a-b-)
REASONS
Transformation into Le (a-b-)
Pregnancy
Cancer
Alcohol cirrhosis
Viral infection
Parasitic infections
Le (a-b-) Transformation into Le (a+b-) or Le (a-b+)
Incubate Le (a-b-) to the PLASMA of Le (a+b-) or Le (a-b+)
If patient 1 is Le (a-b-) and the plasma of patient 2 is Le (a+b-). If the plasma of patient 1 has been incubated to the plasma of patient 2, after the incubation the red cell of patient 1 will be_____
Le (a+b-).
