Ulipristal

Question 1

MoA

Answer 1

Progesterone receptor modulator.
Inhibits or delays ovulation
More effective than levonorgestrel

Question 2

When can it be used?

Answer 2

> 96 - 120 hours after unprotected sex.
Within 5 days of unprotected sex that occurred during 5 days before estimated ovulation.

Question 3

Dose

Answer 3

30 mg
Vomiting < 3 hours = replacement dose

Question 4

Cautions

Answer 4

Severe asthma treated by oral corticosteroids
Liver impairment

Question 5

Contraindications

Answer 5

Repeated use within the same menstrual cycle

Question 6

Patient conselling

Answer 6

Reduces effectiveness of regular contraceptives
Use additional barrier protection
- COC = 14 days (16 if Qlaira)
- POP = 9 days (14 if parenteral)
Wait 5 days before startign regular hormonal contraception OR using levonorgestrel as EHC

Question 7

Side effects

Answer 7

Menstrual irregularities

Question 8

Counselling

Answer 8

1. Next period may be early/late
2. Barrier protection until next period
3. Lower abdominal pain = see GP (to rule out ectopic pregnancy)
4. Abnormal periods = take a pregnancy test (must ne at least 3 weeks after unprotected sex)