UE10 Flashcards

1
Q

étapes hémostase primaire

A

vasoconstriction réflexe
adhérence plaquettaire
activation plaquettaire
agrégation plaquettaire
= clou plaquettaire

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2
Q

coagulation plasmatique

A

cascade de réaction enzymatique mettant en jeu les facteurs de coagulation
transformation du fibrinogène en fibrine
= caillot de fibrine

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3
Q

fibrinolyse

A

lent et progressif
lyse du caillot en parallèle à la cicatrisation

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4
Q

cellules endothéliales

A

non thrombogène

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5
Q

les plaquettes

A

pas de noyau
durée de vie: 7-10j
150-400G/L
GP1B GP2B3A
granules alpha + delta

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6
Q

facteur de Willebrand

A

fixe sous endothélium + plaquettes
transport et protège facteur VIII

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7
Q

fibrinogène

A

protéine plasmatique
synthèse hépatique
matière première du caillot
se fixe au GP1BIIIQ

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8
Q

flip flop membranaire

A

passage des phosphatidylsérines chargés négativement sur le feuillet externe

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9
Q

facteurs vitamine K dépendants (4)

A

II VII IX X

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10
Q

activateurs du plasminogène

A

u-PA + t-PA

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11
Q

inhibiteurs fibrinolyse

A

alpha2-antiplasmine
alpha2-antimacroglobuline

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12
Q

inhibiteurs du u-PA et t-PA

A

PAI-2 et PAI-1

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