UC vs Crohns

Question 1

Transmural inflammation

Answer 1

Crohns

Question 2

Fistula 20%

Answer 2

Crohns

Question 3

Peri-anal disease 25% total

Answer 3

UC

Question 4

Peri-anal disease up to 75%

Answer 4

Crohns

-if small bowel involved –> 75%

Question 5

Pseudopolyps

Answer 5

UC

Question 6

Mucosal inflammation

Answer 6

UC

Question 7

Discrete deep ulcers and fissures

Answer 7

Crohns

Question 8

Multiple small ulcers

Answer 8

UC

Question 9

Crypt architectural distortion

Answer 9

UC

Question 10

Cobblestone appearance

Answer 10

Crohns

Question 11

Goblet cell depletion

Answer 11

UC

Question 12

Granulomas present

Answer 12

Crohns

Question 13

Relative risk of colorectal cancer = 2.5

Answer 13

Crohns

Question 14

Crypt abscess

Answer 14

UC

Question 15

Submucosal chronic inflammatory cell infiltrate

Answer 15

UC

Question 16

25% absolute risk of colorectal cancer

Answer 16

UC
- if pancolitis
/ 30 years

Question 17

Smoking protective

Answer 17

UC

Question 18

Smoking worsens

Answer 18

Crohns

Question 19

CARD15 (NOD2), dysregulation of adaptive immunity

IL23R), and deficient autophagy (ATG16L1, IRGM

Answer 19

Crohns

Question 20

Primary sclerosing cholangitis

Answer 20

UC

Question 21

Rose-thorn ulcers, long

irregular terminal ileal stricture

Answer 21

Crohns

Question 22

Loss of haustrations

Answer 22

UC

Question 23

Widening of the retrorectal space

Answer 23

UC

Due to perirectal inflammation and reduced distensibility of the rectum

Question 24

Colonoscopy should be performed at 2-yearly intervals

Answer 24

UC