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B4W2 > TYPES OF T CELLS > Flashcards

TYPES OF T CELLS Flashcards

1
Q

What are CD4+ Tfh?

A

T folliclar helper cells

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2
Q

what do T follicular helper cells do?

A

help form germinal centres and help B cells produce antibodies

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3
Q

what are CD4+ Th1?

A

T helper 1 cells

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4
Q

what do T helper 1 cells do?

A

to stimulate cell-mediated responses (those involving cytotoxic T cells and macrophages)

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5
Q

what are CD8+ T cells?

A

cytotoxic T cells

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6
Q

what do cytotoxic T cells do?

A

target cells bearing specific antigens and kill them by releasing their cytotoxic granules

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7
Q

what are CD4+ Th2?

A

T helper 2 cells

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8
Q

what do T helper 2 cells do?

A

mediate the activation and maintenance of the humoral immune response against extracellular parasites, bacteria, allergens and toxin (stimulating B cells to make antibodies)

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9
Q

what are CD4+ Th17?

A

T helper 17 cells

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10
Q

what do T helper 17 cells do?

A

play a role in host defence against extracellular pathogens, particularly at the mucosal and epithelial barriers

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11
Q

what are CD4+ Treg?

A

T regulatory cells

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12
Q

whats the function of T regulatory cells?

A

they regulate and suppress other cells in the immune system and therefore help prevent autoimmune disease

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13
Q

what cytokines do T follicular helper cells secrete?

A

Il-10, IL-21

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14
Q

what cytokines do T helper 1 cells secrete?

A

IFN and TNF

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15
Q

what cytokines do T helper 2 cells secrete?

A

IL-4, IL-5 and IL-13

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16
Q

what cytokines do T helper 17 cells secrete?

A

Il-17 and IL-21

17
Q

what cytokines do cytotoxic T lymphocytes secrete?

A

IFN and TNF

18
Q

what cytokines do T regulatory cells secrete?

A

TGF and IL-10

19
Q

what does IFN do?

A

it interferes with viral replication so protects cells from virus infections

20
Q

what does TNF do?

A

regulates immune cells- its able to induce fever, apoptotic cell death and inflammation

21
Q

what does IL-4 do?

A

stimulates activated B-cell and T-cell proliferation and helps with the differentiation of B cells into plasma cells

22
Q

what does IL-5 do?

A

responsible for maturation and release of eosinophils

23
Q

what does IL-10 do?

A

limits the host immune response to pathogens so maintains normal tissue homeostasis

24
Q

what does IL-2 do?

A

regulates the activity of WBC

25
Q

what does Il-17 do?

A

it links T cell activation to neutrophil mobilisation and activation

26
Q

what does IL-21 do?

A

regulates NK cells and cytotoxic T cells that can destroy infected cells. it also induces cell division in its target cell

B4W2 (11 decks)

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