Type 4 Hypersensitivities (Autoimmune Diseases) Flashcards
What is the self antibody being made in Scleroderma?
Scl-70
Autoantibodies will attack what in Scleroderma?
topoisomerase 1
What are 2 important signs in Scleroderma?
Raynauds phenomena
sclerodactyly
Autoantibodies are being made against what in CREST?
anti-centromere
how do you differentiate between CREST and Scleroderma?
CREST has Raynauds and sclerodactyly but additionally has telangiactasis
What are the autoantibodies in SLE?
anti-dsDNA
anti-Smith
what are the 4 symptoms in SLE?
- Malar rash
- photosensitivity
- oral ulcer
- arthritis
what drug induces lupus?
isoniazid
drug induced lupus makes autoantibodies against what?
anti-histones
What are the autoantibodies made in Sjorgren?
anti-ro
anti-la
what symptom is seen in Sjogren/s disease?
dryness in eyes and mouth
what will be infiltrated by antibodies?
exocrine glands
Sjogren disease patients have higher risk of this cancer:
malignant lymphoma
Grave’s disease is an example of what disease?
hyperthyroidism
what is the most common cause of Myasthenia Gravis?
abnormal thymus
in multiple sclerosis, you make autoantibodies against what?
anti-myelin
what 2 symptoms are seen in Multiple Sclerosis?
nystagmus and dysarthria
what happens in rheumatoid arthritis?
autoreactive T helper 2 cells recruit and activate macrophages that release inflammatory cytokines.
The cytokines activate RANK which releases MMP, these degrade bone
what antibody is seen in rheumatoid factor?
IgM
rheumatoid factor destroy’s what?
Fc part of IgG
