Type 2 Hypersensitivity Flashcards
Antigens on neonatal erythrocytes acted on by maternal IgG causing haemolysis and anaemia?
Test for this?
Treatment?
Haemorrhagic disease of newborn
Positive DAT/Coombs
Maternal plasma exchange
Blood group antigens targeted resulting in RBC destruction by self
Test for this?
Treatment?
AIHA
Positive DAT/Coombs
Anti red cell ab
Steroids
GlpIIb/IIIa targeted by antiplatelet antibodies?
Treatment?
ITP
Steroids
IVIG
Anti D
Splenectomy
Type 4 collagen in glomerular BM targeted by anti-GBM ab?
What type of IgG deposits on BM?
Goodpastures
Linear smooth staining of deposits
Epidermal cadherin targeted causing superficial blistering?
Pemphigus vulgaris
Anti TSH receptor causing hyperthyroidism
Graves
Rx carbimazole
Anti acetylcholine receptor causing fatiguable muscle weakness
Myasthenia Gravis
Antigen for rheumatic fever?
M proteins on group A strep
Anti parietal cell and anti IF ab?
Pernicious anaemia
pANCA against myeloperoxidase
Churg Strauss
cANCA against proteinase 3
Wegeners
Microscopic polyangitis antibodies?
pANCA
Persistent itchy wheals lasting 6 weeks associated with angioedema in 50% cases and with IgG against FcR1 or IgE
Chronic urticaria
What happens in a type 2 HS reaction?
An antibody reacts with a self antigen
Results in tissue damage
Can also cause receptor activation or blockade
